| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Philippe Froguel | Q3379857 |
| Nabil Rabhi | Q58035057 | ||
| Jean-Sébastien Annicotte | Q40634433 | ||
| P2093 | author name string | Elisabet Salas | |
| P2860 | cites work | Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress | Q22010800 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response | Q24290935 | ||
| Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress | Q24291026 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells | Q24297587 | ||
| TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death | Q24298384 | ||
| ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
| Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells | Q24299603 | ||
| CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells | Q24301679 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha | Q24310536 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. | Q50706843 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. | Q53181684 | ||
| Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway. | Q54515304 | ||
| Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood | Q55671354 | ||
| WFS1/wolframin mutations, Wolfram syndrome, and associated diseases | Q56803820 | ||
| Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice | Q57198017 | ||
| Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes | Q57920468 | ||
| Translational control of proinsulin synthesis by glucose | Q59096957 | ||
| Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance | Q61993990 | ||
| Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response | Q74359929 | ||
| Optic atrophy in Wolfram (DIDMOAD) syndrome | Q74427625 | ||
| ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum | Q80935578 | ||
| Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 | Q80979487 | ||
| Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II | Q81144490 | ||
| ATF4 regulates lipid metabolism and thermogenesis | Q82468721 | ||
| CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse | Q83315909 | ||
| Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. | Q38346445 | ||
| IRE1-dependent activation of AMPK in response to nitric oxide | Q38960360 | ||
| RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate | Q39038213 | ||
| AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1. | Q39104609 | ||
| Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion | Q39193328 | ||
| Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells | Q39833077 | ||
| An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation | Q39897560 | ||
| ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress | Q40006517 | ||
| The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor | Q40110260 | ||
| High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes | Q40137823 | ||
| Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. | Q40236795 | ||
| Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis | Q40294776 | ||
| ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity | Q40386955 | ||
| Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death | Q24338605 | ||
| Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response | Q24534422 | ||
| Atf4 regulates obesity, glucose homeostasis, and energy expenditure | Q24648259 | ||
| Perk is essential for translational regulation and cell survival during the unfolded protein response | Q28140062 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease | Q28205046 | ||
| WFS1/wolframin mutations, Wolfram syndrome, and associated diseases | Q28214110 | ||
| Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis | Q28258427 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice | Q28359871 | ||
| The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas | Q28505821 | ||
| Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells | Q28508342 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 | Q28511429 | ||
| Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha | Q28512201 | ||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | Q28512249 | ||
| Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state | Q28572472 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion | Q28589308 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction | Q28854565 | ||
| Global estimates of the prevalence of diabetes for 2010 and 2030 | Q29547218 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. | Q33300966 | ||
| The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells | Q33320542 | ||
| Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin | Q33640776 | ||
| Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells | Q33642067 | ||
| IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level | Q33707431 | ||
| Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway | Q33943895 | ||
| PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway | Q34024253 | ||
| The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. | Q34028623 | ||
| OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells | Q34132320 | ||
| Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes | Q34213205 | ||
| Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth | Q34258755 | ||
| The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells | Q34274676 | ||
| Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression | Q34563098 | ||
| Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion | Q35008217 | ||
| In vivo misfolding of proinsulin below the threshold of frank diabetes. | Q35123549 | ||
| BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. | Q36000128 | ||
| Insulin gene mutations as a cause of permanent neonatal diabetes | Q36002587 | ||
| C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells | Q36311167 | ||
| Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis | Q36339591 | ||
| PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis | Q36435206 | ||
| Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). | Q36561426 | ||
| Regulation of the C/EBP-related gene gadd153 by glucose deprivation | Q36694493 | ||
| Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes | Q36796096 | ||
| Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner | Q36796639 | ||
| Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes | Q36861224 | ||
| Initiation and execution of lipotoxic ER stress in pancreatic beta-cells | Q36910693 | ||
| AMPK, insulin resistance, and the metabolic syndrome | Q36966839 | ||
| ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes. | Q37279343 | ||
| The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts | Q37328439 | ||
| Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. | Q37333746 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| Aberrant islet unfolded protein response in type 2 diabetes | Q37576214 | ||
| Endoplasmic reticulum stress in beta-cells and development of diabetes | Q37576455 | ||
| β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome | Q37597032 | ||
| The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology | Q37860033 | ||
| Endocrine and metabolic aspects of the Wolfram syndrome | Q37897156 | ||
| Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. | Q38311676 | ||
| Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage | Q38322371 | ||
| Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells | Q38331321 | ||
| Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation | Q40793113 | ||
| Role for activating transcription factor 3 in stress-induced beta-cell apoptosis | Q41296267 | ||
| Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress | Q42451739 | ||
| Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. | Q42511063 | ||
| The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice | Q44489907 | ||
| Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers | Q46059678 | ||
| The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis | Q46243190 | ||
| Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition | Q46446871 | ||
| Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis | Q46744627 | ||
| Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians | Q46966552 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| regulation of gene expression | Q411391 | ||
| cell | Q7868 | ||
| pancreas | Q9618 | ||
| human digestive system | Q9649 | ||
| hormone | Q11364 | ||
| endocrine system | Q11078 | ||
| diabetes | Q12206 | ||
| biomedical investigative technique | Q66648976 | ||
| biological adaptation | Q67504163 | ||
| insulin-secreting cells | Q70229258 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 795171 | |
| P577 | publication date | 2014-04-09 | |
| P1433 | published in | Journal of Diabetes Research | Q26841822 |
| P1476 | title | Role of the unfolded protein response in β cell compensation and failure during diabetes | |
| P478 | volume | 2014 |
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