The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells

scientific article published on October 31, 2010

The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4093/KDJ.2010.34.5.312
P953full work available online athttps://www.e-dmj.org/upload/pdf/kdj-34-312.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21076579/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21076579/pdf/?tool=EBI
https://europepmc.org/articles/PMC2972491
https://europepmc.org/articles/PMC2972491?pdf=render
https://synapse.koreamed.org/DOIx.php?id=10.4093/kdj.2010.34.5.312
http://e-dmj.org/upload/pdf/kdj-34-312.pdf
https://synapse.koreamed.org/pdf/10.4093/kdj.2010.34.5.312
P932PMC publication ID2972491
P698PubMed publication ID21076579
P5875ResearchGate publication ID47791976

P2093author name stringMi Kyung Kim
In Kyu Lee
Sang Jin Kim
Ho Young Lee
Hye Soon Kim
Hye-Young Seo
Keun Gyu Park
Nam Keong Kim
Young Yun Jang
P2860cites workIdentification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolismQ24294579
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liverQ24304147
TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbetaQ24311973
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
Tribbles: novel regulators of cell function; evolutionary aspectsQ28241602
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisQ28258427
Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specificQ28287662
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasisQ51477990
Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expressionQ53601807
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPKQ55847305
MafA regulates expression of genes important to islet beta-cell functionQ80628439
Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreasQ81118472
Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partnerQ28571879
Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiationQ28573262
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
The role of assembly in insulin's biosynthesisQ28609745
Insulin-promoter-factor 1 is required for pancreas development in miceQ29619695
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
MafA is a key regulator of glucose-stimulated insulin secretionQ33836891
Tripartite management of unfolded proteins in the endoplasmic reticulumQ33941135
The unfolded protein response in nutrient sensing and differentiationQ34664763
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cellsQ34724292
Transcriptional and translational control in the Mammalian unfolded protein responseQ34762452
Impact of Endoplasmic Reticulum Stress Pathway on Pancreatic β-Cells and Diabetes MellitusQ35580872
TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activityQ36176636
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partnerQ36796639
TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosisQ39935621
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistanceQ39989052
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.Q40236795
Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expressionQ40350097
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetesQ40444628
Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin SecretionQ43847819
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.Q44859720
Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndromeQ46581204
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)312-319
P577publication date2010-10-31
P1433published inKorean diabetes journalQ27722980
P1476titleThe Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells
P478volume34

Reverse relations

cites work (P2860)
Q35829685Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review
Q37280479PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability
Q38210545Role of the unfolded protein response in β cell compensation and failure during diabetes

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