| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1035019758 |
| P356 | DOI | 10.1007/S00281-013-0369-5 |
| P698 | PubMed publication ID | 23529219 |
| P2093 | author name string | Takao Iwawaki | |
| Daisuke Oikawa | |||
| P2860 | cites work | A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) | Q22003951 |
| Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein | Q22008011 | ||
| Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors | Q22008465 | ||
| Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress | Q22010800 | ||
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress | Q22254718 | ||
| ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs | Q24290776 | ||
| Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress | Q24290818 | ||
| WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain | Q24290835 | ||
| Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response | Q24290935 | ||
| Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells | Q24297587 | ||
| The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum | Q24298474 | ||
| ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
| Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells | Q24299603 | ||
| Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element | Q24301000 | ||
| A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response | Q24305069 | ||
| The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins | Q24305192 | ||
| SUMO modification regulates the transcriptional activity of XBP1 | Q24307512 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha | Q24310536 | ||
| Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance | Q33673551 | ||
| Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention | Q33688645 | ||
| IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level | Q33707431 | ||
| The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. | Q33777806 | ||
| A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse | Q33834161 | ||
| A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins | Q33938056 | ||
| Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway | Q33943895 | ||
| A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity | Q33966806 | ||
| PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway | Q34024253 | ||
| The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis | Q46243190 | ||
| Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition | Q46446871 | ||
| Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis | Q46744627 | ||
| Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes | Q46810133 | ||
| Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group | Q46825878 | ||
| Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians | Q46966552 | ||
| The effect of insulin and adrenaline on the phosphorylation of a 22 000-molecular weight protein within isolated fat cells; possible identification as the inhibitor-1 of the 'general phosphatase' [proceedings]. | Q47294740 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis | Q52224944 | ||
| Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. | Q52545083 | ||
| Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. | Q53181684 | ||
| Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. | Q53972761 | ||
| Tunicamycin inhibits diabetes. | Q54314432 | ||
| Three mutant insulins in man | Q54498926 | ||
| Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway. | Q54515304 | ||
| Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice. | Q54574033 | ||
| Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood | Q55671354 | ||
| Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK | Q55847305 | ||
| A hybrid protein kinase-RNase in an interferon-induced pathway? | Q56918740 | ||
| Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice | Q57198017 | ||
| ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis | Q57267073 | ||
| Reduced Insulin, GLUT2, and IDX-1 in -Cells After Partial Pancreatectomy | Q60192416 | ||
| Linkage studies for T2D in Chop and C/EBPbeta chromosomal regions in Italians | Q60459267 | ||
| Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance | Q61993990 | ||
| Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes | Q62603232 | ||
| Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels | Q73890030 | ||
| Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 | Q80979487 | ||
| Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and obesity | Q82231857 | ||
| 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP | Q82463495 | ||
| CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse | Q83315909 | ||
| Valsartan protects against ER stress-induced myocardial apoptosis via CHOP/Puma signaling pathway in streptozotocin-induced diabetic rats | Q83463881 | ||
| Wolcott-Rallison syndrome | Q34148057 | ||
| P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling | Q34179244 | ||
| Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity | Q34181503 | ||
| A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto) | Q34220806 | ||
| Sarco(endo)plasmic reticulum Ca 2+ -ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity | Q34320510 | ||
| Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis | Q34358474 | ||
| A compound (DW1182v) protecting high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells preserves islet integrity and improves hyperglycemia in obese db/db mouse | Q34425783 | ||
| β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency | Q34448671 | ||
| Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse | Q34537837 | ||
| Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner | Q34568352 | ||
| The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex | Q34673344 | ||
| Clinical risk factors, DNA variants, and the development of type 2 diabetes | Q34884389 | ||
| Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA. | Q34974859 | ||
| Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion | Q35008217 | ||
| Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors | Q35193940 | ||
| Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes | Q35310496 | ||
| Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism | Q35378742 | ||
| p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis | Q35419603 | ||
| Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells | Q35643714 | ||
| Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice | Q35709954 | ||
| Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses. | Q35766938 | ||
| FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis | Q35841927 | ||
| Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice | Q35870151 | ||
| Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis | Q35887283 | ||
| Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes | Q35895767 | ||
| The role of p58IPK in protecting the stressed endoplasmic reticulum | Q35949048 | ||
| BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. | Q36000128 | ||
| Insulin gene mutations as a cause of permanent neonatal diabetes | Q36002587 | ||
| Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response | Q36029924 | ||
| C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells | Q36311167 | ||
| Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response | Q36322641 | ||
| Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients | Q36385767 | ||
| Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. | Q36393034 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3 | Q24324029 | ||
| BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer | Q24337349 | ||
| CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. | Q24338672 | ||
| Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control | Q24522941 | ||
| Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis | Q24537679 | ||
| Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. | Q24541469 | ||
| The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule | Q24596804 | ||
| Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors | Q24606387 | ||
| Atf4 regulates obesity, glucose homeostasis, and energy expenditure | Q24648259 | ||
| IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response | Q24672592 | ||
| A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus | Q27930818 | ||
| Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway | Q27932953 | ||
| IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae | Q27935778 | ||
| Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Q27938837 | ||
| A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter | Q28119099 | ||
| Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response | Q28139950 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis | Q28258427 | ||
| ASK1 is essential for JNK/SAPK activation by TRAF2 | Q28285612 | ||
| CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription | Q28287446 | ||
| Intracellular signaling from the endoplasmic reticulum to the nucleus | Q28294165 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis | Q28306950 | ||
| A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress | Q28306995 | ||
| Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice | Q28359871 | ||
| The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas | Q28505821 | ||
| Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload | Q28506232 | ||
| Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells | Q39958803 | ||
| ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress | Q40006517 | ||
| Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. | Q40236795 | ||
| Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells | Q40274436 | ||
| Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression | Q40343371 | ||
| WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells | Q40367285 | ||
| ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity | Q40386955 | ||
| 150-kD oxygen-regulated protein is an essential factor for insulin release | Q40433036 | ||
| The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. | Q40453939 | ||
| The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress | Q40503407 | ||
| The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. | Q40581298 | ||
| IPF1, a homeodomain-containing transactivator of the insulin gene | Q40874284 | ||
| Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia | Q40919434 | ||
| Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells | Q41157654 | ||
| Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis | Q41325974 | ||
| The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis | Q41791624 | ||
| Common variants in WFS1 confer risk of type 2 diabetes | Q41852502 | ||
| Insulin gene mutations as cause of diabetes in children negative for five type 1 diabetes autoantibodies | Q41854466 | ||
| The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels | Q41995694 | ||
| The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum | Q42083502 | ||
| TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1 | Q42365354 | ||
| Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress | Q42451739 | ||
| Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. | Q42511063 | ||
| Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins | Q42818320 | ||
| Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation | Q43095387 | ||
| Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. | Q43106855 | ||
| Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. | Q43116152 | ||
| A transgenic mouse model for monitoring endoplasmic reticulum stress | Q44711192 | ||
| Involvement of endoplasmic reticulum stress in insulin resistance and diabetes | Q45127777 | ||
| Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers | Q46059678 | ||
| Endoplasmic reticulum stress plays a central role in development of leptin resistance | Q46178586 | ||
| Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells | Q28507247 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells | Q28508342 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
| XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands | Q28510479 | ||
| Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 | Q28511429 | ||
| Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha | Q28512201 | ||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | Q28512249 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis | Q28576685 | ||
| OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes | Q28580776 | ||
| Cloning of mammalian Ire1 reveals diversity in the ER stress responses | Q28587224 | ||
| Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion | Q28589308 | ||
| ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis | Q28591919 | ||
| Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway | Q28592107 | ||
| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction | Q28592129 | ||
| An essential role in liver development for transcription factor XBP-1 | Q28593777 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice | Q28730861 | ||
| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes | Q29616567 | ||
| Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice | Q29618716 | ||
| Mitochondrial dysfunction in the elderly: possible role in insulin resistance | Q29618783 | ||
| Mitofusin 2 tethers endoplasmic reticulum to mitochondria | Q29619861 | ||
| The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins | Q29620170 | ||
| Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding | Q30308636 | ||
| Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. | Q33267105 | ||
| The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells | Q33320542 | ||
| Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94 | Q33397723 | ||
| Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation | Q33500340 | ||
| Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance | Q33556664 | ||
| A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice | Q33604576 | ||
| Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells | Q33642067 | ||
| Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein | Q33662243 | ||
| Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). | Q36561426 | ||
| Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus | Q36597501 | ||
| Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis | Q36745735 | ||
| Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum | Q36857240 | ||
| Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes | Q36861224 | ||
| Initiation and execution of lipotoxic ER stress in pancreatic beta-cells | Q36910693 | ||
| Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress | Q37141756 | ||
| Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations | Q37161003 | ||
| Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits | Q37166665 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H | Q37280552 | ||
| Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress | Q37324652 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability | Q37377347 | ||
| Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells | Q37388595 | ||
| Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress | Q37419139 | ||
| Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution | Q37506718 | ||
| InterfERing with endoplasmic reticulum stress | Q37960224 | ||
| Apelin, a promising target for type 2 diabetes treatment? | Q37996726 | ||
| XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells | Q38314998 | ||
| Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage | Q38322371 | ||
| AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1 | Q38348926 | ||
| Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder | Q38350959 | ||
| IRE1-dependent activation of AMPK in response to nitric oxide | Q38960360 | ||
| Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pancreatic β-cells by reducing ER stress | Q39280216 | ||
| Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome | Q39299566 | ||
| IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. | Q39299575 | ||
| Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions | Q39424380 | ||
| The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions. | Q39686886 | ||
| Stress-induced gene expression requires programmed recovery from translational repression | Q39735685 | ||
| Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted | Q39759180 | ||
| Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases cAMP-stimulated hepatic gluconeogenesis via inhibition of CREB. | Q39761357 | ||
| Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus | Q39805384 | ||
| IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Q39814866 | ||
| Preventing oxidative stress: a new role for XBP1. | Q39879215 | ||
| Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice | Q39890544 | ||
| P433 | issue | 3 | |
| P304 | page(s) | 333-350 | |
| P577 | publication date | 2013-03-26 | |
| P1433 | published in | Seminars in Immunopathology | Q15724576 |
| P1476 | title | The role of the unfolded protein response in diabetes mellitus | |
| P478 | volume | 35 |
| Q39025066 | Causes and consequences of endoplasmic reticulum stress in rheumatic disease |
| Q42823590 | Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells |
| Q40199093 | Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population |
| Q64059539 | GScluster: network-weighted gene-set clustering analysis |
| Q35536316 | Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells |
| Q38875279 | Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage |
| Q92515239 | Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia |
| Q26995280 | Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia |
| Q48120660 | Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy |
| Q34344097 | Purple perilla extracts allay ER stress in lipid-laden macrophages |
| Q39005579 | Redox status related activation of endoplasmic reticulum stress and apoptosis caused by 4-hydroxynonenal exposure in INS-1 cells |
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