Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis

scientific article

Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.22.16.5639-5649.2002
P8608Fatcat IDrelease_wubv42oif5e6dgo77dkkhrds2u
P932PMC publication ID133973
P698PubMed publication ID12138176

P50authorVikram MisraQ57765186
Peter O'HareQ61306670
P2093author name stringNoreen Rapin
Erin Smith-Windsor
Camilo Raggo
Julie Stirling
Philipe Gobeil
P2860cites workMolecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cellsQ22007975
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latencyQ22011024
Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformationQ22253188
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1Q22254333
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysisQ24310555
Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating proteinQ24320818
Interaction of ATF6 and serum response factorQ24336048
Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factorQ24336173
The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCFQ24523280
Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIPQ24603763
A proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodQ24614744
N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motifQ24649820
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPsQ28115918
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACEQ28139998
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to GolgiQ28141775
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humansQ28145545
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 proteaseQ28344251
Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latencyQ28504545
LZIP-1 and LZIP-2: two novel members of the bZIP familyQ28585015
Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studiesQ28611460
Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteinsQ28640407
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
Presenilins, processing of beta-amyloid precursor protein, and notch signaling.Q33684040
Presenilins: molecular switches between proteolysis and signal transductionQ33730415
Regulated step in cholesterol feedback localized to budding of SCAP from ER membranesQ33916842
Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.Q34424993
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and GolgiQ35644888
Mammalian stress response: induction of the glucose-regulated protein familyQ36183765
A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper familyQ36701321
The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complexQ39727479
Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.Q40109691
The cellular response to unfolded proteins: intercompartmental signalingQ40535495
Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panningQ41028518
Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protectionQ41260355
Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.Q44697855
A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements.Q44998479
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
Cyclic AMP prevents an increase in GAP-43 but promotes neurite growth in cultured adult rat dorsal root ganglion neurons.Q52164368
Transport-Dependent Proteolysis of SREBPQ54231898
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1Q73958442
Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed MutagenesisQ77798021
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
proteolysisQ33123
P304page(s)5639-5649
P577publication date2002-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleLuman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis
P478volume22

Reverse relations

cites work (P2860)
Q37663300A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens
Q91875055A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema
Q24318529A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor
Q24317491A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response
Q33262919Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
Q28082366Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage
Q36673609An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H.
Q36898912Association of the cellular coactivator HCF-1 with the Golgi apparatus in sensory neurons
Q92317240Axotomy Induces Phasic Alterations in Luman/CREB3 Expression and Nuclear Localization in Injured and Contralateral Uninjured Sensory Neurons: Correlation With Intrinsic Axon Growth Capacity
Q24337349BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer
Q42760035CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models.
Q50296854CREB3 translocates from the cytosol to the nucleus
Q24338672CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.
Q55137606CREBH Regulates Systemic Glucose and Lipid Metabolism.
Q64086115Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression
Q38316703Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress
Q42664049Cloning and characterization of rat Luman/CREB3, a transcription factor highly expressed in nervous system tissue.
Q36315764Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity
Q38067504Current drug discovery strategies against arenavirus infections.
Q24320231DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation
Q34041998DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells
Q38178193DC-STAMP, the key fusion-mediating molecule in osteoclastogenesis.
Q38344667Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein
Q37797970Diabetes as a disease of endoplasmic reticulum stress
Q80238624Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2
Q81604029ER stress signaling by regulated proteolysis of ATF6
Q34708452Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor
Q24304232Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
Q26864238Endoplasmic reticulum stress and type 2 diabetes
Q36844431Endoplasmic reticulum stress: signaling the unfolded protein response
Q37602123Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice
Q42237860GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion
Q24815740Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
Q41646513HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress.
Q42184608Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection.
Q35605069Human leucine zipper protein sLZIP induces migration and invasion of cervical cancer cells via expression of matrix metalloproteinase-9.
Q35914983Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice
Q45327325Interplay between hepatitis C virus and ARF4.
Q38316360JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation
Q36223723Knockdown of CREB3/Luman by shRNA in Mouse Granulosa Cells Results in Decreased Estradiol and Progesterone Synthesis and Promotes Cell Proliferation.
Q42322098Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element
Q24300509Luman is capable of binding and activating transcription from the unfolded protein response element
Q41971020Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization
Q24301000Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element
Q50296852MBTPS1 (S1P) cleaves CREB3
Q50296853MBTPS2 (S2P) cleaves CREB3
Q39314148Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF.
Q40034529Novel Brn3a cis-acting sequences mediate transcription of human trkA in neurons.
Q38346133Organelle autoregulation-stress responses in the ER, Golgi, mitochondria and lysosome
Q33543763PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes
Q80098102Primate cytomegalovirus US12 gene family: a distinct and diverse clade of seven-transmembrane proteins
Q37847814Regulated intramembrane proteolysis: signaling pathways and biological functions
Q24293528Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration
Q37352508Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.
Q42952040Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress
Q38149888Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity
Q34526352Sensing nerve injury at the axonal ER: activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal
Q37622607Signalling pathways in the unfolded protein response: development from yeast to mammals
Q50603977Site-1 protease cleavage site is important for the ER stress-induced activation of membrane-associated transcription factor bZIP28 in Arabidopsis.
Q34547044Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors
Q58640364The Unfolded Protein Response and Cholesterol Biosynthesis Link Luman/CREB3 to Regenerative Axon Growth in Sensory Neurons
Q37006310The endoplasmic reticulum and the unfolded protein response
Q38201042The essential biology of the endoplasmic reticulum stress response for structural and computational biologists.
Q24805822The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
Q38253020The neuroimmunology of degeneration and regeneration in the peripheral nervous system.
Q34466767The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication
Q40264454The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors
Q47842101The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization
Q28258161The proprotein convertases and their implication in sterol and/or lipid metabolism
Q38093057The role of the unfolded protein response in diabetes mellitus
Q37860033The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology
Q26851197The site-2 protease
Q79436471The unfolded protein response
Q38784676The unfolded protein response in skeletal development and homeostasis
Q50336411Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis
Q34026175Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy
Q40090967Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells
Q24294669Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman
Q34882839Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA.

Search more.