Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival (scientific article published on 22 January 2014)

A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery

Q21092417

A conditional knockout resource for the genome-wide study of mouse gene function

Q21735918

Defining human ERAD networks through an integrative mapping strategy

Q24298439

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates

Q24298501

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

Q24305231

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

Q24312778

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

Q24313146

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex

Q24338144

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

Q24522524

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane

Q24530318

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

Q27930372

A regulatory link between ER-associated protein degradation and the unfolded-protein response

Q27931238

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

Q27931299

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

Q28131669

Protein misfolding, functional amyloid, and human disease

Q28131732

EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

Q28212764

Regulation of hepatic lipogenesis by the transcription factor XBP1

Q28507784

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

Q28510479

Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality

Q28587457

Essential role of synoviolin in embryogenesis

Q28588247

Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling

Q28588350

Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes

Q28593497

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

Q28593963

Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans

Q28623285

Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice

Q28730861

The unfolded protein response: from stress pathway to homeostatic regulation

Q29547396

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Q29615499

Eukaryotic stress granules: the ins and outs of translation

Q29619569

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

Q33264844

SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells

Q33532789

Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

Q33556664

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates

Q33615098

A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress

Q33641274

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

Q33707431

The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.

Q33967319

SEL1L a multifaceted protein playing a role in tumor progression.

Q34473389

A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease

Q34484551

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

Q34637854

Endoplasmic reticulum stress triggers autophagy

Q35690087

The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue

Q35976791

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

Q36119119

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

Q36358009

Cleaning up: ER-associated degradation to the rescue

Q36464919

Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate

Q36465057

Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress.

Q36540356

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

Q36660203

The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation

Q36680557

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

Q36858538

Purinergic receptors in the endocrine and exocrine pancreas.

Q37119875

The mammalian endoplasmic reticulum-associated degradation system

Q37122324

The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein

Q37272082

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

Q37383994

Synthesis, intracellular transport and discharge of exportable proteins in the pancreatic acinar cell and other cells

Q37792053

Finding the will and the way of ERAD substrate retrotranslocation

Q38031342

Stress granules and cell signaling: more than just a passing phase?

Q38136844

Unravelling the ultrastructure of stress granules and associated P-bodies in human cells.

Q39297506

mSEL-1L (Suppressor/enhancer Lin12-like) protein levels influence murine neural stem cell self-renewal and lineage commitment

Q39567184

The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis

Q39843795

SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains

Q40006668

Exocrine pancreatic insufficiency

Q40912160

Possible involvement of phosphorylation of occludin in tight junction formation

Q41104367

Role of the SEL1L:LC3-I complex as an ERAD tuning receptor in the mammalian ER.

Q44455557

SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases

Q73875542

Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death

Q80531680

P2507

corrigendum / erratum

Correction for Sun et al., Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Q61919925

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

endoplasmic reticulum

Q79927

P304

page(s)

E582-91

P577

publication date

2014-01-22

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

P478

volume

111

Reverse relations

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P819	ADS bibcode	2014PNAS..111E.582S
P356	DOI	10.1073/PNAS.1318114111
P8608	Fatcat ID	release_rlacamhyrvezhlk5hbbzsktuce
P932	PMC publication ID	3918815
P698	PubMed publication ID	24453213
P5875	ResearchGate publication ID	259878163