Possible involvement of phosphorylation of occludin in tight junction formation

scientific article published on June 1997

Possible involvement of phosphorylation of occludin in tight junction formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.137.6.1393
P932PMC publication ID2132539
P698PubMed publication ID9182670
P5875ResearchGate publication ID277495925

P2093author name stringS Tsukita
M Saitou
A Sakakibara
M Furuse
Y Ando-Akatsuka
P2860cites workThe tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctionsQ24316928
Symplekin, a novel type of tight junction plaque proteinQ24317634
The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopyQ24336066
Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assemblyQ24657591
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologuesQ24671949
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsQ24672971
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose platesQ27860715
Mammalian occludin in epithelial cells: its expression and subcellular distributionQ28245297
The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complexQ28289033
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
Isolation of cell-to-cell adherens junctions from rat liverQ28566982
Junctional complexes in various epitheliaQ29620435
A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrierQ34064091
Cingulin, a new peripheral component of tight junctionsQ34172366
Regulated assembly of tight junctions by protein kinase CQ34182877
Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterizationQ36210591
Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cellsQ36218386
Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell linesQ36223952
Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.Q36232347
Assembly of the tight junction: the role of diacylglycerolQ36233397
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor proteinQ36233880
Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cellsQ36236227
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
Structure, function, and regulation of cellular tight junctionsQ36256486
A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sitesQ36530603
Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaquesQ36530637
Occludin is a functional component of the tight junction.Q36828867
Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.Q37487429
The epithelial tight junction: structure, function and preliminary biochemical characterizationQ39546381
Structure, biochemistry, and assembly of epithelial tight junctionsQ39688977
Breaking through the tight junction barrierQ40798811
The molecular organization of tight junctionsQ40903764
The gap junction communication channelQ40974984
The cellular Internet: on-line with connexinsQ41131011
Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structuresQ41231087
Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cellsQ41320069
Structural basis for physiological regulation of paracellular pathways in intestinal epitheliaQ41442657
Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites.Q41477265
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cellsQ41631117
Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.Q43109940
Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulinQ43970551
Intestinal absorptive cell tight junctions are linked to cytoskeletonQ46186998
Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. Application to the immunogold labeling of intercellular junctional complexesQ70964707
Regulation of vascular endothelial barrier functionQ72761942
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P1104number of pages9
P304page(s)1393-1401
P577publication date1997-06-01
P1433published inJournal of Cell BiologyQ1524550
P1476titlePossible involvement of phosphorylation of occludin in tight junction formation
P478volume137

Reverse relations

cites work (P2860)
Q21129349"You Shall Not Pass"-tight junctions of the blood brain barrier
Q37018423A lipid-protein hybrid model for tight junction
Q33841603A local autocrine axis in the testes that regulates spermatogenesis
Q34165229A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells
Q52571268A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection in vitro.
Q54506357A phosphorylation hotspot within the occludin C-terminal domain.
Q33286983A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells
Q40923804A role for intracellular calcium in tight junction reassembly after ATP depletion-repletion
Q42796669A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
Q40360721Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition
Q33816854Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism
Q53219957Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers.
Q39535671Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins
Q45392731Activation of TRPV4 strengthens the tight-junction barrier in human epidermal keratinocytes.
Q36940193Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
Q36316720Advances in nasal drug delivery through tight junction technology
Q28582407Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury
Q37378512An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective
Q37244676An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model
Q35801774Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis
Q28140550Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells
Q40686551Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells
Q24301050Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions
Q26827287Bile duct epithelial tight junctions and barrier function
Q80497624Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin
Q38696206Biphasic influence of Staphylococcus aureus on human epidermal tight junctions
Q36957791Biphasic regulation of mammary epithelial resistance by serotonin through activation of multiple pathways
Q36500479Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy
Q44138424Blood-brain barrier tight junctions are altered during a 72-h exposure to lambda-carrageenan-induced inflammatory pain.
Q37015412Blood-brain barrier: structural components and function under physiologic and pathologic conditions
Q48547667Bone morphogenetic protein 15 may promote follicle selection in the hen.
Q40661068Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins
Q34965558CXCL1 contributes to β-amyloid-induced transendothelial migration of monocytes in Alzheimer's disease
Q39918855Cadherin switching and activation of beta-catenin signaling underlie proinvasive actions of calcitonin-calcitonin receptor axis in prostate cancer
Q36954618Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum
Q34905120Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases
Q33888566Carbohydrate-mediated Golgi to cell surface transport and apical targeting of membrane proteins
Q24317673Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin
Q39308269Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease
Q33340425Cell adhesion, polarity, and epithelia in the dawn of metazoans.
Q92135537Cell junctions and oral health
Q86872397Cell migration
Q40934305Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome
Q50943228Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
Q37621370Cellular elements of the blood-brain barrier
Q40204158Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro
Q58282893Changes in intercellular junctions during apoptosis precede nuclear condensation or phosphatidylserine exposure on the cell surface
Q33891506Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways
Q42910922Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludin
Q39783884Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments
Q38931182Chronic depletion of gonadal testosterone leads to blood-brain barrier dysfunction and inflammation in male mice.
Q24682664Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
Q40900841Claudin-1 contributes to the epithelial barrier function in MDCK cells
Q38110750Claudins and other tight junction proteins
Q40925316Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.
Q40553631Comparative analysis of EspF from enteropathogenic and enterohemorrhagic Escherichia coli in alteration of epithelial barrier function
Q40793623Comparative biochemical and immunocytochemical studies reveal differences in the effects of Clostridium perfringens enterotoxin on polarized CaCo-2 cells versus Vero cells
Q44437836Comparison of ultrastructure, tight junction-related protein expression and barrier function of human corneal epithelial cells cultivated on amniotic membrane with and without air-lifting
Q34781594Complex phenotype of mice lacking occludin, a component of tight junction strands.
Q28578131Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics
Q36293286Connexin-occludin chimeras containing the ZO-binding domain of occludin localize at MDCK tight junctions and NRK cell contacts
Q38038634Continuous endocytic recycling of tight junction proteins: how and why?
Q35627444Contrasting effects of ERK on tight junction integrity in differentiated and under-differentiated Caco-2 cell monolayers
Q24658142Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5
Q48168395Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways
Q24310946Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
Q33853393Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
Q36752296Development and role of tight junctions in the retinal pigment epithelium
Q48492553Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier.
Q42113500Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier
Q24682136Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
Q37412670Discovering the molecular components of intercellular junctions--a historical view.
Q41057559Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni
Q40826540Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1.
Q36779763EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.
Q37458618Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release
Q34388382Effects of Lactobacillus plantarum on gut barrier function in experimental obstructive jaundice
Q48184483Effects of dietary supplementation of arginine-silicate-inositol complex on absorption and metabolism of calcium of laying hens.
Q31153090Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.
Q36123303Effects of peripheral inflammation on the blood-spinal cord barrier
Q39040020Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.
Q36309465Endotoxemia alters tight junction gene and protein expression in the kidney
Q73120415Enhancing paracellular permeability by modulating epithelial tight junctions
Q54021246Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions.
Q46790204Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery
Q30009921Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1
Q38294528Epithelial barrier function and immunity in asthma.
Q34542392Escherichia coli STb enterotoxin dislodges claudin-1 from epithelial tight junctions
Q37035966Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins
Q51761636Estradiol and dihydrotestosterone regulate endothelial cell barrier function after hypergravity-induced alterations in MAPK activity.
Q36681213Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin
Q40806595Etk/Bmx activation modulates barrier function in epithelial cells
Q41614989Evidence for the Involvement of RhoA Signaling in the Ethanol-Induced Increase in Intestinal Epithelial Barrier Permeability
Q40842719Exogenous expression of the amino-terminal half of the tight junction protein ZO-3 perturbs junctional complex assembly
Q48031088Expression of occludin in human rectal carcinoid tumours as a possible marker for glandular differentiation
Q43002291Extracellular signal-regulated protein kinase activation during reoxygenation is required to restore ischaemia-induced endothelial barrier failure
Q36350830Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium
Q37224159Focal adhesion kinase is a blood-testis barrier regulator
Q36986347Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions
Q40691915Gene expression of the tight junction protein occludin includes differential splicing and alternative promoter usage
Q40145683Gut microbiota and immune crosstalk in metabolic disease
Q28078180Gut microbiota and immune crosstalk in metabolic disease
Q48835318HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia
Q95789330HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction
Q36694938Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner
Q24813107Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.
Q40318294Human embryonic stem cell-derived hepatoblasts are an optimal lineage stage for hepatitis C virus infection
Q27653352Identification and Analysis of Occludin Phosphosites: A Combined Mass Spectrometry and Bioinformatics Approach
Q28283564Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells
Q33416683Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis
Q48522592Immunogold study of altered expression of some interendothelial junctional molecules in the brain blood microvessels of diabetic scrapie-infected mice
Q46944568Immunohistological study of tight junction protein expression in mal de Meleda
Q54269295Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.
Q36522913In Vivo and In Vitro Antinociceptive Effect of Fagopyrum cymosum (Trev.) Meisn Extracts: A Possible Action by Recovering Intestinal Barrier Dysfunction
Q36601934In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines
Q40913549In vitro transepithelial drug transport by on-line measurement: cellular control of paracellular and transcellular transport
Q44567711Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice
Q73176659Independent regulation of adherens and tight junctions by tyrosine phosphorylation in Caco-2 cells
Q33703836Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy
Q41612546Interendothelial junctions: structure, signalling and functional roles.
Q40790831Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions
Q33685728Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin
Q47104884Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease.
Q26859272Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases
Q24309562Involvement of actinin-4 in the recruitment of JRAB/MICAL-L2 to cell-cell junctions and the formation of functional tight junctions
Q37591476Irinotecan disrupts tight junction proteins within the gut : implications for chemotherapy-induced gut toxicity.
Q35046911Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation
Q45249905Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.
Q33562329Lactobacillus plantarum inhibits intestinal epithelial barrier dysfunction induced by unconjugated bilirubin
Q28568715Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
Q24291880Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma
Q35046188Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier
Q41964987MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide
Q40707982Maintenance of the epithelial barrier in a bronchial epithelial cell line is dependent on functional E-cadherin local to the tight junctions
Q34198280Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
Q36736442Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
Q30442993Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.
Q39571251Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae
Q40395954Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function
Q40474179Modulation of epithelial morphology, monolayer permeability, and cell migration by growth arrest specific 3/peripheral myelin protein 22
Q50423780Molecular Regulation of Sprouting Angiogenesis
Q33685399Molecular basis of the core structure of tight junctions
Q34446031Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier
Q38139823Monocyte chemoattractant protein-1 and the blood-brain barrier
Q73396773Morphology and physiology of the blood-brain barrier
Q28210051Multifunctional strands in tight junctions
Q33734527Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin
Q40234364Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells
Q46763997Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells
Q28587281Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia
Q33670796Neuron-glial interactions in blood-brain barrier formation.
Q92820010Newly synthesized claudins but not occludin are added to the basal side of the tight junction
Q24515257Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells
Q34684155Occludin 1B, a variant of the tight junction protein occludin
Q34918139Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
Q33659718Occludin and claudins in tight-junction strands: leading or supporting players?
Q77403435Occludin and the functions of tight junctions
Q46412348Occludin expression and regulation in small follicles of the layer and broiler breeder hen.
Q37344103Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
Q45963248Occludin phosphorylation in regulation of epithelial tight junctions.
Q31146058Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2.
Q36289162Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
Q37956234Occludin: one protein, many forms
Q52723966Organic osmolytes preserve the function of the developing tight junction in ultraviolet B-irradiated rat epidermal keratinocytes.
Q46570774Oxidative stress-induced disruption of epithelial and endothelial tight junctions.
Q35621383P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).
Q54079243PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase.
Q82495525Permeability properties and occludin expression in a primary cultured model gill epithelium from the stenohaline freshwater goldfish
Q39607231Perspectives on tight junction research
Q37728541Phosphatase regulation of intercellular junctions
Q43210831Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions
Q36452928Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes
Q36082365Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells
Q36559702Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
Q47588393Phosphorylation of tight junction transmembrane proteins: Many sites, much to do.
Q37054323Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells.
Q30897208Poly-L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro
Q45251310Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells
Q36301696Polyamines regulate expression of E-cadherin and play an important role in control of intestinal epithelial barrier function
Q42436788Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells
Q40302090Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
Q33553682Potential role for a carbohydrate moiety in anti-Candida activity of human oral epithelial cells
Q34187574Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins
Q34081941Protein kinase C activation has distinct effects on the localization, phosphorylation and detergent solubility of the claudin protein family in tight and leaky epithelial cells
Q28212556Protein kinase C regulates the phosphorylation and cellular localization of occludin
Q24673684Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
Q46056499Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers.
Q38304743Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer
Q28544676Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks
Q37082562Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease
Q24337319Rab13 regulates PKA signaling during tight junction assembly
Q30952801Rat testicular myotubularin, a protein tyrosine phosphatase expressed by Sertoli and germ cells, is a potential marker for studying cell-cell interactions in the rat testis
Q40813877Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity
Q33584141Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): an unexpected turn of events
Q34287155Regulation of intestinal epithelial permeability by tight junctions.
Q47351861Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins
Q78004420Regulation of the intestinal epithelial paracellular barrier
Q40832397Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms
Q36908208Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family
Q37442613Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins
Q41700873Requirement for Ras and phosphatidylinositol 3-kinase signaling uncouples the glucocorticoid-induced junctional organization and transepithelial electrical resistance in mammary tumor cells
Q34690508Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells
Q89175098Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis
Q53353778Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa.
Q46908235Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers
Q38862486Roles of Serine/Threonine Phosphatases in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier
Q46766045Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption
Q37571396Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival
Q43884308Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta
Q35073616Sertoli cell tight junction dynamics: their regulation during spermatogenesis
Q43640247Shear stress regulates occludin content and phosphorylation
Q51191281Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells.
Q33744924Structural and signalling molecules come together at tight junctions
Q36272848TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK.
Q37472504Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy
Q28594858The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism
Q34769606The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage
Q28088573The Mammalian Blood-Testis Barrier: Its Biology and Regulation
Q48300181The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells
Q39302506The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases
Q47283509The bile salt sodium taurocholate induces Campylobacter jejuni outer membrane vesicle production and increases OMV-associated proteolytic activity
Q86905010The blood-brain barrier
Q28395237The blood-testis barrier and its implications for male contraception
Q40869408The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
Q24291966The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Q43596281The effects of the Na(+)/Ca(++) exchange blocker on osmotic blood-brain barrier disruption
Q37798825The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease
Q33969502The molecular structure and function of the inner blood-retinal barrier. Penn State Retina Research Group
Q37179982The protein kinase A pathway contributes to Hg2+-induced alterations in phosphorylation and subcellular distribution of occludin associated with increased tight junction permeability of salivary epithelial cell monolayers
Q38124430The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease
Q34617424The role of molecular remodeling in differential regulation of tight junction permeability
Q28204665The roles of claudin superfamily proteins in paracellular transport
Q40439617The second loop of occludin is required for suppression of Raf1-induced tumor growth
Q38753779The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction
Q36660697The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state
Q35777543The tight junction: a multifunctional complex
Q80686035The tight junctional protein occludin is found in the uterine epithelium of squamate reptiles
Q60952879Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals
Q92354281Tight Junctions of the Outer Blood Retina Barrier
Q58098084Tight junction proteins1This review is dedicated to the memory of Thomas Kreis.1
Q46285157Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells
Q28203688Tight junction-related protein expression and distribution in human corneal epithelium
Q38058856Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation
Q37733955Tight junctions in the testis: new perspectives.
Q28145432Tight junctions of the blood-brain barrier
Q24292730Tight junctions of the blood-brain barrier: development, composition and regulation
Q37420725Tight junctions: a barrier to the initiation and progression of breast cancer?
Q36400271Tight junctions: molecular architecture and function
Q24679401Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
Q50554366Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells.
Q44364560Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes
Q44327087Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3.
Q24304509USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly
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