Tight junctions of the blood-brain barrier: development, composition and regulation

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Tight junctions of the blood-brain barrier: development, composition and regulation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S1537-1891(02)00200-8
P3181OpenCitations bibliographic resource ID988061
P698PubMed publication ID12529927

P50authorHartwig WolburgQ32419952
P2093author name stringAndrea Lippoldt
P2860cites workClaudin multigene family encoding four-transmembrane domain protein components of tight junction strandsQ22008687
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorptionQ22010191
Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cellsQ22253974
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesisQ24313372
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1Q24328861
The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopyQ24336066
Syntrophin-dependent expression and localization of Aquaporin-4 water channel proteinQ24555081
Rho protein regulates tight junctions and perijunctional actin organization in polarized epitheliaQ24563849
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologuesQ24671949
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsQ24672971
Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growthQ24678669
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrationQ24682572
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cellsQ24682677
Junctions between intimately apposed cell membranes in the vertebrate brainQ24682725
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinQ24683294
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludinQ28139702
Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cellsQ28140550
Pathobiology of ischaemic stroke: an integrated viewQ28141682
MAGUK proteins: structure and role in the tight junctionQ28145085
Tight junctions of the blood-brain barrierQ28145432
Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinasesQ28198043
A transmembrane tight junction protein selectively expressed on endothelial cells and plateletsQ28201696
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion moleculeQ28203316
The roles of claudin superfamily proteins in paracellular transportQ28204665
Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cellsQ28208656
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.Q41717152
Regulation of the movement of solutes across tight junctionsQ41748263
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentinQ41782223
A cell culture model of the blood-brain barrierQ42006322
Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testisQ42079092
Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin.Q42522519
Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive ratsQ42656327
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsQ42796669
Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathwayQ43565186
Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain TumorsQ43588229
Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula OccludensQ43798217
Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulinQ43970551
Ultrastructural studies of glycoconjugates in brain micro-blood vessels and amyloid plaques of scrapie-infected miceQ45202987
Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementiaQ45747316
Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cellsQ47682013
Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cellsQ48000569
In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesisQ48100987
Early ultrastructural changes in blood-brain barrier vessels of the rat embryoQ48155971
Tight junctions of brain endothelium in vitro are enhanced by astroglia.Q48197798
Quantitative morphology of human glioblastoma multiforme microvessels: structural basis of blood-brain barrier defectQ48259364
Junctions in the meninges and marginal gliaQ48430167
Interendothelial junctions during blood-brain barrier development in the rat: morphological changes at the level of individual tight junctional contactsQ48431124
Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient miceQ48501177
Development of endothelial paracellular clefts and their tight junctions in the pial microvessels of the rat.Q48640865
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.Q48669608
Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells.Q48793608
Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrierQ48822949
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.Q48823528
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouseQ48828901
Development of blood-brain barrier tight junctions in the rat cortexQ48887823
Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in ratsQ48959732
Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice.Q49099695
Multifunctional strands in tight junctionsQ28210051
Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptorQ28254849
Two classes of tight junctions are revealed by ZO-1 isoformsQ28297906
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
Lysophosphatidic acid, a multifunctional phospholipid messengerQ28302384
CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null miceQ28512612
Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase CQ28577565
Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gutQ28581268
COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryosQ29041617
Junctional complexes in various epitheliaQ29620435
The cell biology of the blood-brain barrier.Q33593387
RGS proteins: more than just GAPs for heterotrimeric G proteinsQ33594262
Regulation of matrix metalloproteinase expression in tumor invasion.Q33605726
Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulationQ33656940
Occludin and claudins in tight-junction strands: leading or supporting players?Q33659718
The extracellular matrix of gliomas: modulation of cell functionQ33748808
The neurobiology of duchenne muscular dystrophy: learning lessons from muscle?Q33838297
Pores in the wall: claudins constitute tight junction strands containing aqueous poresQ33881242
Transmembrane proteins of tight junctions.Q34019633
Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental studyQ34032708
Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture.Q34043259
Fracture faces of zonulae occludentes from "tight" and "leaky" epitheliaQ34051800
Fine structural localization of a blood-brain barrier to exogenous peroxidaseQ34054533
Permeability and vascularity of the developing brain: cerebellum vs cerebral cortexQ34056357
Development of the blood-brain barrier to horseradish peroxidase in the chick embryoQ34057423
Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytesQ34060092
A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrierQ34064091
Aquaporins in the central nervous system.Q34104233
GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelinationQ34404861
Molecular physiology and pathophysiology of tight junctions in the blood-brain barrierQ34446031
JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cellsQ34646874
Complex phenotype of mice lacking occludin, a component of tight junction strands.Q34781594
Experimental modulation of occluding junctions in a cultured transporting epitheliumQ36202025
Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.Q49158532
Interendothelial junctional changes underlie the developmental 'tightening' of the blood-brain barrier.Q52257091
Role of the endothelial cytoskeleton in blood-brain-barrier permeability to protein.Q52518555
Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells.Q52967890
Hemodynamics and metabolism in stroke-prone spontaneously hypertensive rats before manifestation of brain infarcts.Q54072115
Localization of the 7H6 antigen at tight junctions correlates with the paracellular barrier function of MDCK cells.Q54193775
Implications of a non-lamellar lipid phase for the tight junction stability. Part II: Reversible modulation of transepithelial resistance in high and low resistance MDCK-cells by basic amino acids, Ca2+, protamine and protonsQ54257079
Tight junction formation in cultured epithelial cells (MDCK).Q54457086
Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins.Q54548198
Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme.Q55475234
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.Q55476886
Glial cells and neurons induce blood-brain barrier related enzymes in cultured cerebral endothelial cells.Q55484176
Blood—Brain Barrier GenomicsQ57677396
Multiple domains of occludin are involved in the regulation of paracellular permeabilityQ58008496
Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctionsQ59096636
Agrin and microvascular damage in Alzheimer’s diseaseQ60145604
Morphological differentiation of endothelial cells co-cultured with astrocytes on type-I or type-IV collagenQ68182697
Freeze-fracture analysis of endothelial cell membranes in rabbit carotid arteries subjected to short-term atherogenic stimuliQ69370547
Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer studyQ69786586
Fibromuscular proliferates induced in vitro using a trans-filter culture systemQ70159101
Morphology of tight junctions in the ciliary epithelium of rabbits during arachidonic acid-induced breakdown of the blood-aqueous barrierQ70301676
Cytochemical evidence for the presence of phospholipids in epithelial tight junction strandsQ70648962
Tight junction complexity in the retinal pigment epithelium of the chicken during developmentQ70651098
Hemodynamic‐Force‐Induced Difference of Interendothelial Junctional ComplexesaQ72107106
Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous systemQ72658005
Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cellsQ73219458
A new model of the blood--brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditionsQ73546390
Neurons and ECM regulate occludin localization in brain endothelial cellsQ73735762
Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signalingQ73869238
Leukocyte adherence contributes to disruption of the blood-brain barrier during activation of mast cellsQ73919903
Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitroQ74038326
Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementiaQ74130130
Participation of plasma membrane proteins in the formation of tight junctions by cultured epithelial cells.Q36207161
Occluding junction structure-function relationships in a cultured epithelial monolayerQ36213963
Assembly of the tight junction: the role of diacylglycerolQ36233397
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor proteinQ36233880
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPasesQ36256190
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarityQ36256216
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cellsQ36316586
Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cordQ36328228
Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM).Q36375485
Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusionQ36670336
Translational diffusion measurements of a fluorescent phospholipid between MDCK-I cells support the lipid model of the tight junctionsQ36739004
The agrin hypothesisQ37577094
Recent studies on the structure and pathology of basement membranesQ39479863
The development of the human blood-brain and blood-CSF barriersQ39746567
Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanismsQ40832397
Rescue of ischemic brain injury by adenoviral gene transfer of glial cell line-derived neurotrophic factor after transient global ischemia in gerbilsQ40839243
Expression of GFRalpha-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB.Q40866074
Occludin modulates transepithelial migration of neutrophils.Q40899347
Claudin-1 contributes to the epithelial barrier function in MDCK cellsQ40900841
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.Q40925316
Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrierQ40942086
Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealingQ40962620
Expression of G-protein subtypes in cultured cerebral endothelial cells.Q41004869
Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctionsQ41016210
Possible involvement of phosphorylation of occludin in tight junction formationQ41104367
Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesisQ41157924
Segmental differentiations of cell junctions in the vascular endothelium. Arteries and veinsQ41202146
Identification of isoforms of G proteins and PKC that colocalize with tight junctionsQ41231542
Tight junctions in the choroid plexus epithelium. A freeze-fracture study including complementary replicasQ41249770
A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptideQ41498808
Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationshipsQ41577366
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
blood–brain barrierQ221694
CingulinQ5120918
P304page(s)323-37
P577publication date2002-06-01
P1433published inVascular PharmacologyQ7916446
P1476titleTight junctions of the blood-brain barrier: development, composition and regulation
P478volume38

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Q47286331Fatty acid binding protein 5 mediates the uptake of fatty acids, but not drugs, into human brain endothelial cells
Q48707747Fibronectin promotes brain capillary endothelial cell survival and proliferation through alpha5beta1 and alphavbeta3 integrins via MAP kinase signalling
Q36404218Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model
Q91638523Fish oil protects the blood-brain barrier integrity in a mouse model of Alzheimer's disease
Q34577621Fluids and barriers of the CNS: a historical viewpoint
Q30477576Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
Q36638592Frog Virus 3 dissemination in the brain of tadpoles, but not in adult Xenopus, involves blood brain barrier dysfunction
Q55455023Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases.
Q28534449Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish
Q37080750Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)
Q36633623Gene dysregulation is restored in the Parkinson's disease MPTP neurotoxic mice model upon treatment of the therapeutic drug Cu(II)(atsm).
Q41382687Ginsenoside Rg1 nanoparticle penetrating the blood-brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction
Q52606336Glia-induced reversible disruption of blood-brain barrier integrity and neuropathological response of the neurovascular unit.
Q33660218Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse
Q38152380Glial influence on the blood brain barrier.
Q50076163Glioblastoma Stem Cells and Their Microenvironment
Q40064513Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro
Q26853743Glucocorticoids and endothelial cell barrier function
Q35067385Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro
Q46403676Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity
Q39396702Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells
Q36914297Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease.
Q33965984Holey barrier: claudins and the regulation of brain endothelial permeability
Q26995364How do immune cells support and shape the brain in health, disease, and aging?
Q93136005Human ES-derived MSCs correct TNF-α-mediated alterations in a blood-brain barrier model
Q36707822Hyperbaric oxygen preconditioning ameliorates blood-brain barrier damage induced by hypoxia through modulation of tight junction proteins in an in vitro model
Q39038770Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism
Q93003140Hypoxia-induced disruption of neural vascular barrier is mediated by the intracellular induction of Fe(II) ion
Q58768157Hypoxic pre-conditioning suppresses experimental autoimmune encephalomyelitis by modifying multiple properties of blood vessels
Q38272285Immune responses to non-tumor antigens in the central nervous system.
Q48427172Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex
Q47280497Immunolocalization of tight junction proteins in the adult and developing human brain
Q54629759Immunological Response in Early Brain Injury After SAH
Q37701119Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line
Q35782792In vitro blood-brain barrier models: current and perspective technologies
Q34476565In vitro cerebrovascular modeling in the 21st century: current and prospective technologies
Q34185789In vitro study of the effects of Angiostrongylus cantonensis larvae extracts on apoptosis and dysfunction in the blood-brain barrier (BBB).
Q42861335Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system
Q37215932Increasing importance of Balamuthia mandrillaris
Q39628237Increasing of Blood-tumor Barrier Permeability through Paracellular Pathway by Low-frequency Ultrasound Irradiation In Vitro
Q36059965Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models
Q28538281Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes
Q35107973Interaction of micron and nano-sized particles with cells of the dura mater
Q35708089Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings
Q45923746Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions.
Q52562684Interfacing Graphene-Based Materials With Neural Cells.
Q38725361Into rather unexplored terrain-transcellular transport across the blood-brain barrier
Q46890566Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells
Q52654675Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of first filial generation pubertal Wistar rats.
Q34229756Late stage infection in sleeping sickness
Q40742606Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.
Q34041547Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling
Q36314837Limb Ischemic Perconditioning Attenuates Blood-Brain Barrier Disruption by Inhibiting Activity of MMP-9 and Occludin Degradation after Focal Cerebral Ischemia
Q38078421Liposomes for brain delivery
Q30362081Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound
Q37777780Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches
Q41845503Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke
Q57823139Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke
Q37739229Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
Q35578905MPP1 as a Factor Regulating Phase Separation in Giant Plasma Membrane-Derived Vesicles
Q35751741Manganese neurotoxicity: a focus on the neonate
Q38366240Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain
Q47843849Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug-Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment
Q33998763Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins
Q35920564Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage
Q42474751Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5.
Q39463653Mechanisms for endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier
Q64448505Mechanisms of Blood Brain Barrier Disruption by Different Types of Bacteria, and Bacterial-Host Interactions Facilitate the Bacterial Pathogen Invading the Brain
Q52654285Melatonin treatment protects against acute spinal cord injury-induced disruption of blood spinal cord barrier in mice.
Q37682953Mesocestoides corti intracranial infection as a murine model for neurocysticercosis
Q37209324Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life
Q38117056Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research
Q37184157Microbial induction of vascular pathology in the CNS.
Q41670106Microdevice Platform for In Vitro Nervous System and Its Disease Model.
Q38199403Microfluidic approaches for epithelial cell layer culture and characterisation
Q36980988Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow.
Q50295671Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction.
Q36220289Models and mechanisms for hippocampal dysfunction in obesity and diabetes
Q38774697Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids
Q38010642Molecular and cellular mechanisms underlying the role of blood vessels in spinal cord injury and repair
Q38139823Monocyte chemoattractant protein-1 and the blood-brain barrier
Q35849990Monocytes form a vascular barrier and participate in vessel repair after brain injury
Q35154529Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders
Q38824367Morphogens and blood-brain barrier function in health and disease
Q48714712Morphological approach to assess the involvement of astrocytes in prion propagation
Q46503083Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium.
Q37776054Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms
Q37798870Nano to micro delivery systems: targeting angiogenesis in brain tumors
Q38156382Nano-enabled delivery systems across the blood-brain barrier
Q38334868Nanomaterials and neurodegeneration.
Q64064209Nanomaterials for Drug Delivery to the Central Nervous System
Q26747148Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases
Q38275050Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance
Q30672749Nanoprobes visualizing gliomas by crossing the blood brain tumor barrier
Q38115775Neural circuit mechanisms of post-traumatic epilepsy
Q52689036Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions.
Q57811980Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response
Q26745615Neuroinvasion and Inflammation in Viral Central Nervous System Infections
Q33670796Neuron-glial interactions in blood-brain barrier formation.
Q35653077Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Q36492361Neuroprotection in primary brain tumors: sense or nonsense?
Q36942721Neurovascular unit in chronic pain
Q85102460Neutrophils cross the BBB primarily on transcellular pathways: An in vitro study
Q30440266Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature
Q37083995Noninvasive molecular neuroimaging using reporter genes: part II, experimental, current, and future applications
Q37176938Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia
Q48524462OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co-glycolic acid) nanoparticles: synthesis, characterization and evaluation of its brain delivery ability
Q36248862Ontogeny of tight junction protein expression in the ovine cerebral cortex during development
Q64265564Oral Mucosal Epithelial Cells
Q35575520Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees
Q38836349Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin
Q37610820Past and recent BBB studies with particular emphasis on changes in ischemic brain edema: dedicated to the memory of Dr. Igor Klatzo
Q26777643Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products
Q37592281Pathogen translocation across the blood-brain barrier
Q58701395Pathogenesis of hepatic encephalopathy
Q38111646Pathogenesis of meningococcemia
Q26852773Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers
Q41988859Pcbs and tight junction expression
Q40306137Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria.
Q92421241Pericytes in Glioblastomas: Multifaceted Role Within Tumor Microenvironments and Potential for Therapeutic Interventions
Q38039410Perlecan and the blood-brain barrier: beneficial proteolysis?
Q39024369Permeability of the blood-tumor barrier is enhanced by combining vascular endothelial growth factor with papaverine
Q36166111Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.
Q28265568Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model
Q36559702Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
Q42215950Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier
Q46592570Polychlorinated biphenyls impair blood-brain barrier integrity via disruption of tight junction proteins in cerebrum, cerebellum and hippocampus of female Wistar rats: neuropotential role of quercetin
Q40302090Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
Q37381816Progranulin deficiency promotes post-ischemic blood-brain barrier disruption
Q34043168Protection after stroke: cellular effectors of neurovascular unit integrity.
Q39069181Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability
Q37157311Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis
Q37812799Proteomics of human cerebrospinal fluid: Discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics
Q38541950RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies
Q42514650Real-time acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood-brain barrier model exemplifies tight-junction integrity.
Q31154008Recent advances in blood-brain barrier disruption as a CNS delivery strategy
Q47378913Recent advances in nanomedicine and survivin targeting in brain cancers
Q34873529Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage
Q39906454Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin
Q48925891Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier
Q36986806Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit
Q42694289Retinal and Cortical Blood Flow Dynamics Following Systemic Blood-Neural Barrier Disruption
Q36091834Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures.
Q45028397Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte loss
Q58551285Review Article: Capturing the physiological complexity of the brain's neuro-vascular unit
Q33488361Role of KCNMA1 gene in breast cancer invasion and metastasis to brain
Q48515470Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase
Q54584375Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.
Q35127976Role of interendothelial adhesion molecules in the control of vascular functions
Q41830315Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice
Q39449749Role of the Golgi Apparatus in the Blood-Brain Barrier: Golgi Protection May Be a Targeted Therapy for Neurological Diseases.
Q37899111Role of the MAGUK protein family in synapse formation and function.
Q38862486Roles of Serine/Threonine Phosphatases in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier
Q92846319Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel
Q38697509Sepsis-Associated Encephalopathy: The Blood-Brain Barrier and the Sphingolipid Rheostat
Q96686012Sex dependent effects of post-natal penicillin on brain, behavior and immune regulation are prevented by concurrent probiotic treatment
Q28203769Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
Q37124122Species-Dependent Blood-Brain Barrier Disruption of Lipopolysaccharide: Amelioration by Colistin In Vitro and In Vivo
Q50282885Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult.
Q26995931Steps to translate preconditioning from basic research to the clinic
Q38182668Strategies for drug delivery to the central nervous system by systemic route
Q38730602Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier
Q30871112Studying the neurovascular unit: an improved blood-brain barrier model
Q91161153Sublamina-specific organization of the blood brain barrier in the mouse olfactory nerve layer
Q37161062Superoxide dismutase-loaded PLGA nanoparticles protect cultured human neurons under oxidative stress
Q36287281Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
Q48223017Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture.
Q45876651Systemic delivery of scAAV9 in fetal macaques facilitates neuronal transduction of the central and peripheral nervous systems.
Q36449224TAT-GDNF in neurodegeneration and ischemic stroke.
Q27010580Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide
Q38598523Targeting brain metastases in ALK-rearranged non-small-cell lung cancer.
Q37810007The Blood-Retinal Barrier: Structure and Functional Significance
Q36832869The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology?
Q42114054The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress
Q51732646The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.
Q58790366The Hippocampal Neuro-Glio-Vascular Network: Metabolic Vulnerability and Potential Neurogenic Regeneration in Disease
Q37603088The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.
Q86905010The blood-brain barrier
Q37385549The blood-brain barrier in neurodegenerative disease: a rhetorical perspective
Q38134725The blood-brain barrier: an engineering perspective.
Q38232202The blood-brain barrier: structure, function and therapeutic approaches to cross it.
Q28299076The blood-brain-barrier in multiple sclerosis: functional roles and therapeutic targeting
Q48196105The distribution and expression of claudin-5 and occludin at the rat blood-optic nerve barrier after borneol treatment
Q37156631The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.
Q30450592The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats
Q35413892The gut microbiota influences blood-brain barrier permeability in mice
Q34442604The impact of microglial activation on blood-brain barrier in brain diseases.
Q33648688The molecular and biophysical characterization of the human blood-nerve barrier: current concepts
Q33898503The role of shear stress in Blood-Brain Barrier endothelial physiology
Q39756110The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
Q47403727The temporospatial expression of peripheral myelin protein 22 at the developing blood-nerve and blood-brain barriers
Q47724056Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer's disease
Q30407443Therapeutic strategies to improve drug delivery across the blood-brain barrier
Q40512823Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.
Q38193357Tight junction dynamics: the role of junctional adhesion molecules (JAMs).
Q36812411Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
Q36410566Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras.
Q37139446Tight junctions and the modulation of barrier function in disease
Q36400271Tight junctions: molecular architecture and function
Q39006683Time-resolved cellular effects induced by TcdA from Clostridium difficile
Q90529676Tissue Plasminogen Activator Causes Brain Microvascular Endothelial Cell Injury After Oxygen Glucose Deprivation by Inhibiting Sonic Hedgehog Signaling
Q44992417Tissue plasminogen activator expression and barrier properties of human brain microvascular endothelial cells.
Q36991072Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.
Q35751067Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.
Q28484634Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues
Q37394773Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function
Q34328845Transcriptome analysis of the Octopus vulgaris central nervous system
Q48752367Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice
Q35622297Triggers and mediators of hemorrhagic transformation in cerebral ischemia
Q92405024Tumor microenvironment differences between primary tumor and brain metastases
Q33217988Tumoral micro-blood vessels and vascular microenvironment in human astrocytic tumors. A transmission electron microscopy study
Q44701197Use of albumin quotient and IgG index to differentiate blood- vs brain-derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis
Q47357133VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy
Q88905954Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling
Q35947353Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance
Q92309537Weisheng-Tang Ameliorates Acute Ischemic Brain Damage in Mice by Maintaining Blood-Brain Barrier Integrity
Q22251221Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity
Q38958450miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.
Q33819951miR-Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition.
Q44819014t-PA reduces ischemic impairment of blood-brain barrier by strengthening endothelium junction
Q41430066β2-Adrenergic Receptor-Mediated HIF-1α Upregulation Mediates Blood Brain Barrier Damage in Acute Cerebral Ischemia