Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5.

scientific article published on 27 March 2015

Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011399791
P356DOI10.1007/S10456-015-9464-7
P698PubMed publication ID25812799

P2093author name stringRichard Milner
Amin Boroujerdi
Jennifer V Welser-Alves
P2860cites workAbsence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiationQ22008650
Tight junctions of the blood-brain barrier: development, composition and regulationQ24292730
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesQ24628843
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Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude miceQ36143628
Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in β1 integrinsQ36211381
Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brainQ36580516
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.Q36644315
Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unitQ36986806
Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.Q37034232
Multiphasic roles for matrix metalloproteinases after strokeQ37069644
Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbraQ37106947
A novel and simple method for culturing pericytes from mouse brainQ37106956
TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusionQ37173457
Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brainQ37329753
Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory painQ37543496
Reduced retinal angiogenesis in MMP-2-deficient miceQ40547231
Transforming growth factor beta1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesisQ41136241
Use of gel zymography to examine matrix metalloproteinase (gelatinase) expression in brain tissue or in primary glial cultures.Q41377495
Matrix metalloproteinases increase very early during experimental focal cerebral ischemiaQ41671816
Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct sizeQ42455530
Basic FGF and TGF-beta differentially modulate integrin expression of human microvascular endothelial cellsQ46376070
Developmental regulation of beta1 integrins during angiogenesis in the central nervous systemQ46571780
Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha5beta1 and alphavbeta5.Q48147066
Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brainQ48384389
Time-course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter densityQ48888132
Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching.Q51786158
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.Q53659623
P433issue3
P921main subjecthypoxiaQ105688
P304page(s)255-264
P577publication date2015-03-27
P1433published inAngiogenesisQ15753544
P1476titleMatrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5.
P478volume18

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cites work (P2860)
Q41641630Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord
Q28072886Extracellular Matrix, a Hard Player in Angiogenesis
Q52146607MMP-2 Is Mainly Expressed in Arterioles and Contributes to Cerebral Vascular Remodeling Associated with TGF-β1 Signaling.
Q58599383Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis
Q39277398Neurovascular Alterations in Alzheimer's Disease: Transporter Expression Profiles and CNS Drug Access
Q37655625Propofol protects against blood-spinal cord barrier disruption induced by ischemia/reperfusion injury
Q36709376Tongxinluo Reverses the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells

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