Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein

scientific article

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.134.4.1031
P932PMC publication ID2120963
P698PubMed publication ID8769425

P2093author name stringGonzález S
Flores C
Cereijido M
Balda MS
Matter K
Whitney JA
P2860cites workOccludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsQ24672971
Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membraneQ24673790
The scanning model for translation: an updateQ24679648
Junctional complexes in various epitheliaQ29620435
Regulation of cell surface polarity from bacteria to mammalsQ35532352
Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells: polarity of an apical protein is independent of tight junctions while segregation of a basolateral marker requires cell-cell interactionsQ36216030
Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cellsQ36218386
Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistanceQ36221153
Assembly of the tight junction: the role of diacylglycerolQ36233397
Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells.Q36234444
Permeability of Luminal Surface of Intestinal Mucosal CellsQ36374169
Structure of tight junctions in epithelia with different permeabilityQ37460393
Cation permeation mechanisms and cation selectivity in "tight junctions" of gallbladder epitheliumQ37625153
Mechanisms of cell polarity: sorting and transport in epithelial cellsQ40647437
The structure and regulation of tight junctionsQ40780311
Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structuresQ41231087
Polarized monolayers formed by epithelial cells on a permeable and translucent supportQ41233493
Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cellsQ41526657
Selective inhibition of transcytosis by brefeldin A in MDCK cellsQ41657515
ATP depletion: a novel method to study junctional properties in epithelial tissues. I. Rearrangement of the actin cytoskeleton.Q42484467
The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cellsQ42570947
Basolateral sorting of LDL receptor in MDCK cells: the cytoplasmic domain contains two tyrosine-dependent targeting determinantsQ43610720
Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula OccludensQ43798217
Establishment of tight junctions between cells from different animal species and different sealing capacitiesQ44556091
Effects of pH and polyvalent cations on the selective permeability of gall-bladder epithelium to monovalent ionsQ44654125
Dimensions of polar pathways through rabbit gallbladder epithelium. The effect of phloretin on nonelectrolyte permeabilityQ47857007
Further observations on the fine structure of freeze-cleaved tight junctions.Q53816155
Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cellsQ57253842
ZO-1 and cingulin: tight junction proteins with distinct identities and localizationsQ58098197
Membrane asymmetry in epithelia: is the tight junction a barrier to diffusion in the plasma membrane?Q59093204
Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctionsQ59096636
Altered hepatic localization and expression of occludin after common bile duct ligationQ71552878
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
P1104number of pages19
P304page(s)1031-1049
P577publication date1996-08-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleFunctional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
P478volume134

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Q30425823Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism
Q46279792Probiotic strains and mechanistic insights for the treatment of type 2 diabetes.
Q54067603Prolactin, alone or in combination with glucocorticoids, enhances tight junction formation and expression of the tight junction protein occludin in mammary cells.
Q28212556Protein kinase C regulates the phosphorylation and cellular localization of occludin
Q37095009Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol
Q39535911Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1.
Q36794215ROCK activity regulates functional tight junction assembly during blastocyst formation in porcine parthenogenetic embryos
Q80149165Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug
Q39847326Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes.
Q34104062Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria
Q43276210Redox-sensitivity of the dimerization of occludin
Q28365900Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability
Q37423257Regulation and roles for claudin-family tight junction proteins
Q78004420Regulation of the intestinal epithelial paracellular barrier
Q33306608Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2
Q39336324Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells
Q38091094Regulation of tight junctions in upper airway epithelium
Q40461193Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury.
Q34563926Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin
Q73884961Remodeling of junctional complexes during the development of the outer blood-retinal barrier
Q37438622Remodeling of the tight junction during recovery from exposure to hydrogen peroxide in kidney epithelial cells
Q35544541Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct
Q34690508Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells
Q91656937Rho Flares Repair Local Tight Junction Leaks
Q37687727Rho signaling and tight junction functions
Q37854547Role of LKB1-SAD/MARK pathway in neuronal polarization
Q36952081Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170
Q40700929Role of nectin in organization of tight junctions in epithelial cells
Q38594976Role of tight junctions in signal transduction: an update.
Q47104349Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells
Q58734316Rotavirus-Induced Early Activation of the RhoA/ROCK/MLC Signaling Pathway Mediates the Disruption of Tight Junctions in Polarized MDCK Cells
Q33804515Rotavirus-induced structural and functional alterations in tight junctions of polarized intestinal Caco-2 cell monolayers
Q40251331Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function
Q92839143Schistosoma japonicum serine protease inhibitor increases endothelial barrier function
Q39998597Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5.
Q41969584Sensing of EGTA Mediated Barrier Tissue Disruption with an Organic Transistor
Q42769911Sensing of barrier tissue disruption with an organic electrochemical transistor
Q43884308Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta
Q36491366Shear stress regulates aquaporin-5 and airway epithelial barrier function
Q28203769Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
Q39604115Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
Q41854266Sphingosine-1-Phosphate Regulates the Expression of Adherens Junction Protein E-Cadherin and Enhances Intestinal Epithelial Cell Barrier Function
Q30424223Spontaneous, immune-mediated gastric inflammation in SAMP1/YitFc mice, a model of Crohn's-like gastritis.
Q27334502Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion
Q38898593Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum
Q36256190Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases
Q33744924Structural and signalling molecules come together at tight junctions
Q33914550Structural correlates of the transepithelial water transport
Q64065025Structural dynamics of tight junctions modulate the properties of the epithelial barrier
Q51779617Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets.
Q41952134Surreptitious manipulation of the human host by Helicobacter pylori
Q35855634Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery
Q38242808Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
Q37008522The "polarizing-tolerizing" mechanism of intestinal epithelium: its relevance to colonic homeostasis
Q39407355The Effect of Commonly Used Excipients on the Epithelial Integrity of Human Cervicovaginal Tissue
Q52726876The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2.
Q36734066The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis
Q28088573The Mammalian Blood-Testis Barrier: Its Biology and Regulation
Q89619633The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period
Q30176715The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain
Q33740929The Yin and Yang of bile acid action on tight junctions in a model colonic epithelium
Q36322940The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
Q34931170The blood-brain barrier
Q34320420The blood-brain barrier in health and disease
Q40869408The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
Q40999209The cytoplasmic domains of a beta1 integrin mediate polarization in Madin-Darby canine kidney cells by selective basolateral stabilization
Q33326554The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier
Q30159960The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB.
Q87954480The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function
Q39376508The inner blood-retinal barrier: Cellular basis and development
Q30010066The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability
Q90867704The protective effect of selenium from heat stress-induced porcine small intestinal epithelial cell line (IPEC-J2) injury is associated with regulation expression of selenoproteins
Q82263885The role of EFA6, exchange factor for Arf6, for tight junction assembly, functions, and interaction with the actin cytoskeleton
Q33640010The role of cell adhesion molecules in ischemic acute renal failure
Q40052094The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells
Q40439617The second loop of occludin is required for suppression of Raf1-induced tumor growth
Q24299510The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells
Q30654463The spatial organization of apical junctional complex-associated proteins in feline and human corneal endothelium
Q37840099The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease
Q30175138The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression
Q52941644The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1.
Q35777543The tight junction: a multifunctional complex
Q53262327Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1.
Q92354281Tight Junctions of the Outer Blood Retina Barrier
Q36812411Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
Q44522285Tight junction peptide antagonists enhance neutrophil trans-endothelial chemotaxis
Q83226328Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex
Q43018186Tight junction proteins in zebrafish ovarian follicles: stage specific mRNA abundance and response to 17beta-estradiol, human chorionic gonadotropin, and maturation inducing hormone
Q58098084Tight junction proteins1This review is dedicated to the memory of Thomas Kreis.1
Q37118065Tight junction proteins: from barrier to tumorigenesis.
Q46522622Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
Q38180780Tight junction regulation through vesicle trafficking: bringing cells together
Q46285157Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells
Q34086502Tight junction, a platform for trafficking and signaling protein complexes
Q24299926Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions
Q52889385Tight junctions and differentiation--a chicken or the egg question?
Q37139446Tight junctions and the modulation of barrier function in disease
Q38058856Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation
Q33674271Tight junctions in salivary epithelium
Q28145432Tight junctions of the blood-brain barrier
Q24292730Tight junctions of the blood-brain barrier: development, composition and regulation
Q33801524Tight junctions: closing in on the seal
Q38879992Tight junctions: from simple barriers to multifunctional molecular gates
Q36400271Tight junctions: molecular architecture and function
Q48361620Time-course investigation of blood-brain barrier permeability and tight junction protein changes in a rat model of permanent focal ischemia
Q28581494Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands
Q77436497Transfer of [3H]estrone-[35S]sulfate across guinea pig fetal membranes
Q48553630Transplantation of human umbilical cord blood cells mediated beneficial effects on apoptosis, angiogenesis and neuronal survival after hypoxic-ischemic brain injury in rats
Q27690256Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?
Q81326881Trichomonas vaginalis perturbs the junctional complex in epithelial cells
Q38482451Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology
Q50554366Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells.
Q54062477Two secreted retinal factors regulate different stages of development of the outer blood-retinal barrier.
Q89063384VCAM-1 induces signals that stimulate ZO-1 serine phosphorylation and reduces ZO-1 localization at lung endothelial cell junctions
Q30403557Vocal fold epithelial barrier in health and injury: a research review
Q30157199ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
Q24683294ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
Q35756679Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
Q64239829enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

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