The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function

scientific article published on 23 May 2014

The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000362789
P932PMC publication ID6742956
P698PubMed publication ID24862212

P2093author name stringTakashi Ueno
Hideoki Ogawa
François Niyonsaba
Ko Okumura
Shigaku Ikeda
Tsutomu Fujimura
Hiroko Ushio
Chanisa Kiatsurayanon
Toan The Nguyen
Toshihiro Akiyama
P2860cites workContribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytesQ24317104
GSK-3: tricks of the trade for a multi-tasking kinaseQ24624069
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complexQ24673684
Permeability barrier dysfunction in transgenic mice overexpressing claudin 6Q28211420
Physiology and function of the tight junctionQ28270069
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient miceQ28513737
Rac GTPase interacts specifically with phosphatidylinositol 3-kinaseQ28646209
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonQ30157199
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complexQ30443412
Myosin-X functions in polarized epithelial cellsQ30513859
Occludin is required for cytokine-induced regulation of tight junction barriersQ34043395
Innate antimicrobial peptide protects the skin from invasive bacterial infectionQ34102960
Regulated assembly of tight junctions by protein kinase CQ34182877
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expressionQ34284161
Tight junction defects in patients with atopic dermatitis.Q34629278
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanismQ35613903
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epitheliaQ35756679
Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)Q35849738
Mammalian tight junctions in the regulation of epithelial differentiation and proliferationQ36228546
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
Claudins and epithelial paracellular transportQ36387912
Tight junctions/adherens junctions: basic structure and functionQ36970229
Crosstalk of tight junction components with signaling pathwaysQ36976365
Multifunctional antimicrobial proteins and peptides: natural activators of immune systemsQ37550872
Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domainQ40432691
Endogenous antimicrobial peptides and skin infections in atopic dermatitisQ40698186
Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokinesQ42458101
Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutesQ42960019
Tight junctions form a barrier in human epidermisQ43803447
PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum.Q44185456
Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cellsQ44243354
Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown.Q45995065
Identification of differentially expressed genes in psoriasis using expression profiling approachesQ46648325
Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.Q52598343
Characterization of tight junctions and their disruption by UVB in human epidermis and cultured keratinocytes.Q52606028
Tight junctions and differentiation--a chicken or the egg question?Q52889385
Disease concomitance in psoriasis.Q54171239
Role of aPKC Isoforms and Their Binding Partners Par3 and Par6 in Epidermal Barrier FormationQ59591352
Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokinesQ79306603
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasisQ79774033
Tight junction proteins in keratinocytes: localization and contribution to barrier functionQ79947223
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytesQ80833051
CD44 regulates tight-junction assembly and barrier functionQ83060215
P433issue6
P921main subjectkeratinocyteQ1473931
P304page(s)739-753
P577publication date2014-05-23
P1433published inJournal of Innate ImmunityQ15817533
P1476titleThe human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function
P478volume6

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cites work (P2860)
Q92824253A Novel Peptide Ameliorates LPS-Induced Intestinal Inflammation and Mucosal Barrier Damage via Its Antioxidant and Antiendotoxin Effects
Q92405115Cathelicidin-WA Facilitated Intestinal Fatty Acid Absorption Through Enhancing PPAR-γ Dependent Barrier Function
Q90027967Cecropin A Modulates Tight Junction-Related Protein Expression and Enhances the Barrier Function of Porcine Intestinal Epithelial Cells by Suppressing the MEK/ERK Pathway
Q38436135Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses
Q47999919Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis.
Q38403654Epidermal tight junctions in health and disease.
Q37524101IL-1β-Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human β-Defensin 2.
Q40091655Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense
Q26776055Regulation of the Intestinal Barrier Function by Host Defense Peptides
Q39407147Scaffolding proteins in the development and maintenance of the epidermal permeability barrier
Q39010646Tight junctions in skin inflammation
Q92066717Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches

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