ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton

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ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton is …
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scholarly articleQ13442814

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P356DOI10.1091/MBC.E09-04-0320
P932PMC publication ID2735491
P698PubMed publication ID19605556

P2093author name stringAlan S Fanning
James M Anderson
Arlene Bridges
Christina M Van Itallie
P2860cites workRegulation of epithelial apical junctional complex by Rho family GTPasesQ22241271
Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1Q22254323
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteinsQ24301160
Rocks: multifunctional kinases in cell behaviourQ24303641
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Tricellulin is a tight-junction protein necessary for hearingQ24337885
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expressionQ24536188
Rho protein regulates tight junctions and perijunctional actin organization in polarized epitheliaQ24563849
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosinQ24670442
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsQ24672971
Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin FilamentsQ24678389
Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cellsQ24679401
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrationQ24682572
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinQ24683294
Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoAQ24685209
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion moleculeQ28203316
Multifunctional strands in tight junctionsQ28210051
Tight junction proteinsQ28217124
Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transitionQ28248100
Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activationQ28253319
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctionsQ28256167
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeabilityQ28365900
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctionsQ28511375
Shroom regulates epithelial cell shape via the apical positioning of an actomyosin networkQ28590605
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)Q28609825
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding propertiesQ30159513
Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cellsQ30159938
Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cellsQ30165410
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosisQ30476106
Dynamic behavior of paired claudin strands within apposing plasma membranesQ30477728
ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherensQ30483283
Dimerization of the scaffolding protein ZO-1 through the second PDZ domainQ33247516
Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2Q33306608
Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cellsQ34071220
Claudins create charge-selective channels in the paracellular pathway between epithelial cellsQ34132571
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
The cytoplasmic plaque of tight junctions: a scaffolding and signalling centerQ34761497
Composition and function of PDZ protein complexes during cell polarizationQ35188696
Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical applicationQ35569905
A porous defense: the leaky epithelial barrier in intestinal disease.Q35651435
The tight junction: a multifunctional complexQ35777543
Mechanism of brush border contractility studied by the quick-freeze, deep-etch methodQ36208203
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPasesQ36256190
Twenty-first Bowditch lecture. The epithelial junction: bridge, gate, and fenceQ36320057
Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeabilityQ36324231
Determination of the effective hydrodynamic radii of small molecules by viscometryQ36373962
Claudins and epithelial paracellular transportQ36387912
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cellsQ36678082
Altered permeability in inflammatory bowel disease: pathophysiology and clinical implicationsQ36838883
Adherens and tight junctions: structure, function and connections to the actin cytoskeletonQ36940193
Biology of claudins.Q36956748
Actin motors that drive formation and disassembly of epithelial apical junctionsQ37175764
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.Q37266104
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctionsQ37524262
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.Q39745580
Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.Q40011405
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.Q40024709
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architectureQ40156403
Barrier function of epitheliaQ40321241
Establishment and characterization of cultured epithelial cells lacking expression of ZO-1.Q40528997
Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1.Q40700804
Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomersQ40794057
Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cellsQ40855515
Molecular decipherment of Rho effector pathways regulating tight-junction permeabilityQ40896655
Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayersQ41432245
Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells.Q41485174
Regulation of the movement of solutes across tight junctionsQ41748263
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expressionQ45083340
A novel strategy for the enhancement of drug absorption using a claudin modulatorQ45188971
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Q45345068
Intestinal absorptive cell tight junctions are linked to cytoskeletonQ46186998
Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and sizeQ47301250
Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular poresQ47608346
Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia.Q52543811
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.Q53965794
Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins.Q54548198
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structureQ57179984
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylationQ73847660
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)3930-3940
P577publication date2009-07-15
P1433published inMolecular Biology of the CellQ2338259
P1476titleZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
P478volume20

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