JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

scientific article

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E13-06-0298
P3181OpenCitations bibliographic resource ID4923305
P932PMC publication ID3771947
P698PubMed publication ID23885123

P50authorThilo StehleQ1473254
Asma NusratQ77916415
Terence S. DermodyQ87776424
P2093author name stringRandy A Hall
Stacy A Schaefer
Dirk M Reiter
Charles A Parkos
Giovanna Leoni
Michael J Mina
Ana C Monteiro
Ronen Sumagin
Carl R Rankin
P2860cites workPDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2Q22010969
Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1Q22254323
Rap2A links intestinal cell polarity to brush border formationQ24293320
Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteinsQ24297397
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction controlQ24322066
Gapped BLAST and PSI-BLAST: a new generation of protein database search programsQ24545170
Rho protein regulates tight junctions and perijunctional actin organization in polarized epitheliaQ24563849
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junctionQ24678766
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motifQ27634027
Crystal structure of human junctional adhesion molecule 1: Implications for reovirus bindingQ27640992
Structure of Reovirus σ1 in Complex with Its Receptor Junctional Adhesion Molecule-AQ27653146
Crystal Structure of Reovirus Attachment Protein σ1 in Complex with Sialylated OligosaccharidesQ27671651
The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1Q27675242
Human junction adhesion molecule regulates tight junction resealing in epitheliaQ28138238
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludinQ28139702
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architectureQ28191564
Size-selective loosening of the blood-brain barrier in claudin-5-deficient miceQ28203769
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2Q28208774
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domainQ28281838
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonQ30157199
ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherensQ30483283
Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinctionQ30486818
A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctionsQ33292672
Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cellsQ33647027
Molecular basis of the core structure of tight junctionsQ33685399
P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2Q33841106
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivoQ34014510
Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cellsQ34071220
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
Protein database searches using compositionally adjusted substitution matricesQ34293765
JAM-A regulates epithelial proliferation through Akt/β-catenin signallingQ34797342
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epitheliaQ35756679
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formationQ35839775
Intracellular mediators of JAM-A-dependent epithelial barrier functionQ36238728
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPasesQ36256190
JAM-A regulates permeability and inflammation in the intestine in vivoQ36294373
Tight Junction Pore and Leak Pathways: A Dynamic DuoQ36305755
Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitisQ36588077
Cis-dimerization mediates function of junctional adhesion molecule A.Q36631107
Rap1: a key regulator in cell-cell junction formationQ36689667
Epac: effectors and biological functionsQ37051159
Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migrationQ37146658
Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.Q37487429
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesionQ39707989
Investigation of the binding preference of reovirus sigma1 for junctional adhesion molecule A by classical and steered molecular dynamicsQ39906475
Reovirus binding determinants in junctional adhesion molecule-A.Q40142387
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architectureQ40156403
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.Q40262405
The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytesQ40602867
Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanismsQ40832397
Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulationQ40842464
Structural basis for physiological regulation of paracellular pathways in intestinal epitheliaQ41442657
Involvement of afadin in barrier function and homeostasis of mouse intestinal epitheliaQ41843715
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actinQ42459171
Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.Q42663964
Rac and Rap GTPase activation assays.Q46614459
Involvement of the junctional adhesion molecule-1 (JAM1) homodimer interface in regulation of epithelial barrier function.Q52553035
Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis.Q52567219
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structureQ57179984
P4510describes a project that usesImageJQ1659584
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
regulation of actin cytoskeleton reorganizationQ14873996
Tight junction protein 1Q21096429
Rap guanine nucleotide exchange factor 2Q21107982
F11 receptorQ21108779
RAB1B, member RAS oncogene familyQ21109098
RAB1A, member RAS oncogene familyQ21113198
RAP2B, member of RAS oncogene familyQ21113507
Rap guanine nucleotide exchange factor 6Q21117600
Tight junction protein 2Q21119271
RAP2C, member of RAS oncogene familyQ21121212
Afadin, adherens junction formation factorQ21172887
F11 receptorQ21988190
P304page(s)2849-60
P577publication date2013-09-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleJAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function
P478volume24

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cites work (P2860)
Q47157018Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Q38425671Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor.
Q42514276Afadin orients cell division to position the tubule lumen in developing renal tubules
Q26785540Alterations of the apical junctional complex and actin cytoskeleton and their role in colorectal cancer progression
Q34624331Architecture of tight junctions and principles of molecular composition
Q33799746Breaking barriers. New insights into airway epithelial barrier function in health and disease
Q57813171CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway
Q44912536Cell-Cell Junctions Organize Structural and Signaling Networks
Q26828514Claudins: Gatekeepers of lung epithelial function
Q47408707Defenders and Challengers of Endothelial Barrier Function
Q38382439Dysregulation of cell-cell interactions in brain arteriovenous malformations: A quantitative proteomic study
Q47134866Dysregulation of junctional adhesion molecule-A contributes to ethanol-induced barrier disruption in intestinal epithelial cell monolayers.
Q48244856EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions
Q38403637Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration
Q34663672Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation
Q33675740Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion
Q54190905Identification of novel retinoic acid target genes.
Q90928684In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines
Q38902578Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
Q47851530Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment
Q90205918Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation
Q58699535JAM-A knockdown accelerates the proliferation and migration of human keratinocytes, and improves wound healing in rats via FAK/Erk signaling
Q38199343JAM-related proteins in mucosal homeostasis and inflammation
Q47771280Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development.
Q35008519Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function
Q47295333Junctional adhesion molecule-A: functional diversity through molecular promiscuity.
Q48748595Kudiezi Injection(®) Alleviates Blood-Brain Barrier Disruption After Ischemia-Reperfusion in Rats
Q90591063Laminin-driven Epac/Rap1 regulation of epithelial barriers on decellularized matrix
Q35755835Leukocyte-epithelial interactions and mucosal homeostasis
Q36061317Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol
Q64989375Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice.
Q47296050MicroRNA-105 is involved in TNF-α-related tumor microenvironment enhanced colorectal cancer progression
Q35234759Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function
Q38809434Neutrophil-Epithelial Interactions: A Double-Edged Sword
Q64265564Oral Mucosal Epithelial Cells
Q30826769Remodeling the zonula adherens in response to tension and the role of afadin in this response
Q39212077Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function
Q37319461RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex
Q37617010Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms.
Q50887047Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.
Q90194169Succinate Modulates Intestinal Barrier Function and Inflammation Response in Pigs
Q35909871The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins
Q91738199The Cytoplasmic Expression Of CLDN12 Predicts An Unfavorable Prognosis And Promotes Proliferation And Migration Of Osteosarcoma
Q90499640The mechanobiology of tight junctions
Q38193357Tight junction dynamics: the role of junctional adhesion molecules (JAMs).
Q33604368Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface
Q92874332ZO-2 Is a Master Regulator of Gene Expression, Cell Proliferation, Cytoarchitecture, and Cell Size
Q39246229ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation.

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