Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis (scientific article published on 13 September 2012)

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

Q24678065

Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration

Q24682572

Human junction adhesion molecule regulates tight junction resealing in epithelia

Q28138238

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

Q28511506

Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease

Q28586834

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

Q29547656

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Q29619339

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Q29622850

Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury.

Q30476048

Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways

Q33808592

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

Q34556464

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

Q34590015

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease

Q34693075

The regulation of IgA class switching.

Q34708215

JAM-A regulates epithelial proliferation through Akt/β-catenin signalling

Q34797342

Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

Q35091226

Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins

Q35747165

JAM-A regulates permeability and inflammation in the intestine in vivo

Q36294373

Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice

Q36375395

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

Q36402737

Cis-dimerization mediates function of junctional adhesion molecule A.

Q36631107

Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications

Q36838883

Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration

Q37146658

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.

Q37428976

Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice

Q37486598

Regulatory T cells reinforce intestinal homeostasis

Q37600194

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice

Q39438688

E-cadherin expression in intestinal epithelium

Q39642426

Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity.

Q40464555

Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen

Q40701079

Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.

Q41418413

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

Q42134773

Increased intestinal permeability in patients with inflammatory bowel disease.

Q45152551

Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration

Q56904883

Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits

Q57128380

Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora

Q57135946

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

Q72233696

TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo

Q73168724

Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells

Q73555512

A mucosal IgA-mediated excretory immune system in vivo

Q73586916

Inflammatory bowel disease is associated with changes of enterocytic junctions

Q74025969

Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes

Q74595815

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

Q77291206

Alterations in classical cadherins associated with progression in ulcerative and Crohn's colitis

Q77367047

Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease

Q77600680

TGF-beta receptor signaling is critical for mucosal IgA responses

Q80475685

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

563-573

P577

publication date

2012-09-13

P1433

published in

Immunity

Q6005457

P1476

title

Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis

P478

volume

Reverse relations

cites work (P2860)

Q40030432	AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection
Q37357912	Advances in nutritional research on regulatory T-cells
Q42346717	All Hands on Deck: Commensals, Th17 Cells, and Neutrophils Provide Short-term Compensation of Constitutive Permeability Defects Against Acute Infection.
Q36497289	Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
Q24318444	Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
Q33787065	Association of levels of antibodies from patients with inflammatory bowel disease with extracellular proteins of food and probiotic bacteria.
Q58799139	Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa
Q36827240	CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells
Q44912536	Cell-Cell Junctions Organize Structural and Signaling Networks
Q26768643	Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue
Q21131205	Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics
Q42085461	Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells.
Q98287666	Coordinated co-migration of CCR10+ antibody-producing B cells with helper T cells for colonic homeostatic regulation
Q42176588	Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
Q91604150	Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia
Q90277758	Functions of EpCAM in physiological processes and diseases (Review)
Q64079613	Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 T-Cell Activation
Q39102508	Gut permeability and mucosal inflammation: bad, good or context dependent.
Q32115630	Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis
Q36597803	Inflammation and colorectal cancer: colitis-associated neoplasia
Q38902578	Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
Q35148051	Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway
Q42373419	Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation.
Q38190874	Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Q34439832	Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice.
Q34438743	Intestinal inflammation and mucosal barrier function
Q97643545	Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer
Q49167863	Isolation and gene expression profiling of intestinal epithelial cells: crypt isolation by calcium chelation from in vivo samples
Q24311647	JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function
Q38199343	JAM-related proteins in mucosal homeostasis and inflammation
Q47771280	Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development.
Q35008519	Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function
Q47295333	Junctional adhesion molecule-A: functional diversity through molecular promiscuity.
Q36061317	Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol
Q47413203	Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis
Q64989375	Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice.
Q37011812	Mechanisms of Intestinal Barrier Dysfunction in Sepsis
Q58774497	Mechanisms regulating intestinal barrier integrity and its pathological implications
Q39339639	Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel Disease
Q38953543	Molecular pathways driving disease-specific alterations of intestinal epithelial cells
Q38734297	Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis
Q38809434	Neutrophil-Epithelial Interactions: A Double-Edged Sword
Q39016237	Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation.
Q36785206	Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis
Q38936511	Pathobiology of neutrophil-epithelial interactions
Q38286264	Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton
Q49569343	Role of DDX3 in the pathogenesis of inflammatory bowel disease
Q58603309	Role of gut microbiota in intestinal wound healing and barrier function
Q38226548	T cells and intestinal commensal bacteria--ignorance, rejection, and acceptance
Q34457032	Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis.
Q40099296	The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability
Q38193357	Tight junction dynamics: the role of junctional adhesion molecules (JAMs).
Q36051970	Transcriptional Changes in CD8(+) T Cells During Antiretroviral Therapy Intensified With Raltegravir

P356	DOI	10.1016/J.IMMUNI.2012.06.017
P932	PMC publication ID	3564580
P698	PubMed publication ID	22981539