Tight Junction Pore and Leak Pathways: A Dynamic Duo

scientific article published on January 1, 2011

Tight Junction Pore and Leak Pathways: A Dynamic Duo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1146/ANNUREV-PHYSIOL-012110-142150
P953full work available at URLhttps://europepmc.org/articles/pmc4655434?pdf=render
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev-physiol-012110-142150
https://europepmc.org/articles/PMC4655434
https://europepmc.org/articles/PMC4655434?pdf=render
https://doi.org/10.1146/annurev-physiol-012110-142150
https://www.annualreviews.org/doi/pdf/10.1146/annurev-physiol-012110-142150
P932PMC publication ID4655434
P698PubMed publication ID20936941
P5875ResearchGate publication ID47394774

P50authorChristopher R. WeberQ41830369
Dan YuQ58955545
P2093author name stringLe Shen
Jerrold R. Turner
David R. Raleigh
P2860cites workParacellin-1, a renal tight junction protein required for paracellular Mg2+ resorptionQ22010191
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functionsQ24299926
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1Q24312184
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Rab13 regulates PKA signaling during tight junction assemblyQ24337319
A novel claudin 16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargetingQ24532149
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expressionQ24536188
Deconstructing the cadherin-catenin-actin complexQ24609677
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsQ24672971
Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cellsQ24679401
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
A fine structural analysis of intercellular junctions in the mouse liverQ24682661
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
Structure of the claudin-binding domain of Clostridium perfringens enterotoxinQ27648943
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architectureQ28191564
Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segmentsQ28209952
Multifunctional strands in tight junctionsQ28210051
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cellsQ28214827
Occludin confers adhesiveness when expressed in fibroblastsQ28239917
Physiology and function of the tight junctionQ28270069
Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubulesQ28279525
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeabilityQ28365900
Effect of plant cytokinins on microfilaments and tight junction permeabilityQ59056568
Evidence for the lipidic nature of tight junction strandsQ59087871
Regulation of epithelial tight junction permeability by cyclic AMPQ59095849
Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host diseaseQ64381640
Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the ratQ68541193
Intestinal conductance and permselectivity changes with theophylline and choleragenQ68854263
Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factorQ69656337
Passive water flows driven across the isolated rabbit ileum by osmotic, hydrostatic and electrical gradientsQ70091685
Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colonQ70451456
Physiological regulation of intestinal epithelial tight junctions as a consequence of Na(+)-coupled nutrient transportQ71737295
Intestinal permeability and the prediction of relapse in Crohn's diseaseQ72220492
Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microfloraQ73221864
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylationQ73847660
Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trialQ77374966
The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stabilityQ80561465
Regulation of heterotypic claudin compatibilityQ80797514
Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patternsQ82468003
Permeable junctional complexes. The movement of lanthanum across rabbit gallbladder and intestineQ41161439
Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epitheliaQ41193303
Structural basis for physiological regulation of paracellular pathways in intestinal epitheliaQ41442657
Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationshipsQ41577366
Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeabilityQ41597813
Paracellular glucose transport plays a minor role in the unanesthetized dog.Q41611927
Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transportQ42494774
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsQ42796669
NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epitheliaQ43766328
Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransportQ43797549
Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula OccludensQ43798217
Intestinal permeability in patients with Crohn's disease and their healthy relativesQ43863082
Vibrating probe analysis of teleost opercular epithelium: correlation between active transport and leak pathways of individual chloride cellsQ43956933
Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice.Q44094636
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cellsQ44217456
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.Q45249905
Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expressionQ45258065
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Q45345068
A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitisQ46395791
Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cellsQ46520833
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.Q46592696
Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular poresQ47608346
Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha.Q51525902
Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants.Q52536053
Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis.Q52969889
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.Q53965794
Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model.Q54042487
Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins.Q54548198
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structureQ57179984
JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulinQ28591650
Intestinal mucosal barrier function in health and diseaseQ29618086
Junctional complexes in various epitheliaQ29620435
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonQ30157199
Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: potential mechanism of tight junction regulationQ30164050
The primary defect in experimental ileitis originates from a nonhematopoietic sourceQ30439653
Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cellsQ30442081
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosisQ30476106
Dynamic behavior of paired claudin strands within apposing plasma membranesQ30477728
Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4.Q30882635
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's diseaseQ33249005
Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxinQ33557833
Molecular basis of the core structure of tight junctionsQ33685399
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivityQ33782512
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivoQ33788423
MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier functionQ33929240
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivoQ34014510
Occludin is required for cytokine-induced regulation of tight junction barriersQ34043395
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membraneQ34049874
Fracture faces of zonulae occludentes from "tight" and "leaky" epitheliaQ34051800
Epithelial barriers in homeostasis and diseaseQ34093056
Claudins create charge-selective channels in the paracellular pathway between epithelial cellsQ34132571
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's diseaseQ34145454
Cingulin, a new peripheral component of tight junctionsQ34172366
Signalling to and from tight junctionsQ34180670
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin IIQ34205231
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
Standing-gradient osmotic flow. A mechanism for coupling of water and solute transport in epitheliaQ34244613
Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complexQ34359173
Palmitoylation of claudins is required for efficient tight-junction localizationQ34403266
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitutionQ34440722
Intestinal permeability in children with Crohn's disease and coeliac diseaseQ34761994
Complex phenotype of mice lacking occludin, a component of tight junction strands.Q34781594
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivoQ35052412
Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.Q35322212
Occluding junctions and cytoskeletal components in a cultured transporting epitheliumQ36202080
Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structureQ36207416
Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivityQ36215124
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor proteinQ36233880
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctionsQ36289162
JAM-A regulates permeability and inflammation in the intestine in vivoQ36294373
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cellsQ36316586
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complexQ36330886
Claudins and epithelial paracellular transportQ36387912
The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady stateQ36660697
Effect of claudins 6 and 9 on paracellular permeability in MDCK II cellsQ36977167
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformationQ36982054
Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction siteQ37023274
LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.Q37259782
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.Q37266104
Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host diseaseQ37388077
Structure-function studies of claudin extracellular domains by cysteine-scanning mutagenesis.Q37431293
Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large moleculesQ39723716
Claudin-16 affects transcellular Cl- secretion in MDCK cellsQ39837634
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3.Q39853561
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.Q40024709
Formation of tight junction: determinants of homophilic interaction between classic claudins.Q40087090
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2.Q40129999
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.Q40262405
On tight-junction structureQ40264285
Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cellsQ40345251
Contribution of claudin-5 to barrier properties in tight junctions of epithelial cellsQ40374324
Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like processQ40415725
Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cellsQ40538742
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeationQ40666802
Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1.Q40700804
Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cellsQ40855515
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junctionQ40869408
Tight junctions are membrane microdomainsQ40886204
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.Q40925316
Rapid reduction of MDCK cell cholesterol by methyl-beta-cyclodextrin alters steady state transepithelial electrical resistanceQ40931447
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouseQ41122462
P407language of work or nameEnglishQ1860
P304page(s)283-309
P577publication date2011-01-01
P1433published inAnnual Review of PhysiologyQ567364
P1476titleTight Junction Pore and Leak Pathways: A Dynamic Duo
P478volume73

Reverse relations

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Q35698851Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model
Q30519492Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
Q37218681Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice
Q37151738Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells
Q36057629MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
Q37327077MMP20 modulates cadherin expression in ameloblasts as enamel develops.
Q49171448Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.
Q24338226MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival
Q42013864MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.
Q37716726Means to Facilitate the Overcoming of Gastric Juice Barrier by a Therapeutic Staphylococcal Bacteriophage A5/80.
Q89442831Mechanisms and Regulation of Intestinal Phosphate Absorption
Q37717492Mechanisms and pathways of Toxoplasma gondii transepithelial migration
Q37011812Mechanisms of Intestinal Barrier Dysfunction in Sepsis
Q52663659Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats.
Q42513194Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receptor-dependent pathway in rats in vivo
Q37142513Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin.
Q93204707Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ-mediated phosphorylation of occludin
Q38328002MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions.
Q34714938Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon
Q53818544Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Q36708833Microgavage of zebrafish larvae
Q52691745Modulation of Intestinal Paracellular Transport by Bacterial Pathogens.
Q26852912Modulation of cell-cell junctional complexes by matrix metalloproteinases
Q40079685Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation.
Q39607225Modulation of tight junction proteins in the perineurium for regional pain control.
Q37982360Modulation of tight junction structure and function by kinases and phosphatases targeting occludin
Q26864785Molecular aspects of tight junction barrier function
Q57477853More complete polarization of renal tubular epithelial cells by artificial urine
Q38734297Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis
Q31057409Myosin light chain kinase mediates intestinal barrier disruption following burn injury
Q38739653Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury.
Q36062835Myosin light chain kinase: pulling the strings of epithelial tight junction function
Q30513859Myosin-X functions in polarized epithelial cells
Q39281815NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.
Q99560227Nanotopography Enhances Dynamic Remodeling of Tight Junction Proteins through Cytosolic Liquid Complexes
Q46242347Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight junction protein degradation
Q90317473Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models
Q36785206Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis
Q36234461Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions
Q26772345Nutritional Keys for Intestinal Barrier Modulation
Q40563819Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability.
Q30009590Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux
Q34918139Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
Q34580003Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis
Q35057031Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
Q89519661Ophiopogon Saponin C1 Inhibits Lung Tumors by Stabilizing Endothelium Permeability via Inhibition of PKCδ
Q42352756Outer Membrane Vesicles and Soluble Factors Released by Probiotic Escherichia coli Nissle 1917 and Commensal ECOR63 Enhance Barrier Function by Regulating Expression of Tight Junction Proteins in Intestinal Epithelial Cells
Q38202849Oxygen in the regulation of intestinal epithelial transport
Q39785153PEGylated silicon nanowire coated silica microparticles for drug delivery across intestinal epithelium
Q33779763Paracellular transport through healthy and cystic fibrosis bronchial epithelial cell lines--do we have a proper model?
Q38988993Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea
Q39607231Perspectives on tight junction research
Q37728541Phosphatase regulation of intercellular junctions
Q52366670Phosphorylation hotspot in the C-terminal domain of occludin regulates the dynamics of epithelial junctional complexes.
Q36452928Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes
Q92677838Physiology of Electrolyte Transport in the Gut: Implications for Disease
Q35739433Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells
Q34166824Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins
Q39207967Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid
Q36760282Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
Q37396622Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications
Q35928397Protective Effects of Ferulic Acid against Heat Stress-Induced Intestinal Epithelial Barrier Dysfunction In Vitro and In Vivo
Q61812360Protective Effects of Live Combined and in Polymicrobial Sepsis Through Modulating Activation and Transformation of Macrophages and Mast Cells
Q94453282Protective effect of emodin on intestinal epithelial tight junction barrier integrity in rats with sepsis induced by cecal ligation and puncture
Q26865861Pulmonary epithelial barrier function: some new players and mechanisms
Q92785707R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing
Q38978743Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals
Q35846716Regulation of epithelial permeability by the actin cytoskeleton
Q38141920Regulation of paracellular permeability: factors and mechanisms.
Q34442093Renal control of calcium, phosphate, and magnesium homeostasis
Q90507291Respiratory microbiome and epithelial interactions shape immunity in the lungs
Q49936255Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers
Q91656937Rho Flares Repair Local Tight Junction Leaks
Q39212077Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function
Q37194601Role of autophagy in the regulation of epithelial cell junctions
Q34888133Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens
Q26827692Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract
Q58603309Role of gut microbiota in intestinal wound healing and barrier function
Q93086454SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility
Q40630977Salmosan, a β-Galactomannan-Rich Product, Protects Epithelial Barrier Function in Caco-2 Cells Infected by Salmonella enterica Serovar Enteritidis
Q39407147Scaffolding proteins in the development and maintenance of the epidermal permeability barrier
Q34425563Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome.
Q91942859Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice
Q41808104Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices
Q35118493Simultaneous gas-chromatographic urinary measurement of sugar probes to assess intestinal permeability: use of time course analysis to optimize its use to assess regional gut permeability
Q34850153Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junction
Q37224841Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice
Q64065025Structural dynamics of tight junctions modulate the properties of the epithelial barrier
Q39944908Subacute stress and chronic stress interact to decrease intestinal barrier function in rats.
Q35043980TGFβs modulate permeability of the blood-epididymis barrier in an in vitro model
Q34059619TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions
Q37042932TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.
Q39134068Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network
Q93216356Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
Q89771573Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency
Q34583490The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation
Q34769606The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage
Q89552148The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium
Q36832696The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks
Q56968515The Sandwich Assay: A Method for Subcellular Visualization of Paracellular Macromolecule Passage in Epithelial Sheets
Q89965220The Uptake, Trafficking, and Biodistribution of Bacteroides thetaiotaomicron Generated Outer Membrane Vesicles
Q38134725The blood-brain barrier: an engineering perspective.
Q28395237The blood-testis barrier and its implications for male contraception
Q91722641The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation
Q34277822The inner foreskin of healthy males at risk of HIV infection harbors epithelial CD4+ CCR5+ cells and has features of an inflamed epidermal barrier
Q39009998The intestinal epithelial barrier: a therapeutic target?
Q90499640The mechanobiology of tight junctions
Q39071909The mucosal barrier at a glance.
Q97093738The past, present and future of intestinal in vitro cell systems for drug absorption studies
Q27007776The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease
Q34665037The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders.
Q38184626The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjögren's syndrome.
Q34617424The role of molecular remodeling in differential regulation of tight junction permeability
Q38753779The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction
Q40864710Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.
Q38017702Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances
Q39363574Tight junctions of the proximal tubule and their channel proteins
Q89744172Total Flavonoid Extract from Hawthorn (Crataegus pinnatifida) Improves Inflammatory Cytokines-Evoked Epithelial Barrier Deficit
Q90296333Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway
Q36307543Transcriptomic profile of leg muscle during early growth in chicken.
Q38079085Transepithelial antigen delivery in the small intestine: different paths, different outcomes
Q41662112Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells
Q35539714Tricellulin and its role in the epididymal epithelium of the rat.
Q48157550Tumor Necrosis Factor-α Increases Claudin-1, 4, and 7 Expression in Tubular Cells: Role in Permeability Changes
Q39309675VIP and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome.
Q64940620Villus Growth, Increased Intestinal Epithelial Sodium Selectivity, and Hyperaldosteronism Are Mechanisms of Adaptation in a Murine Model of Short Bowel Syndrome.
Q34289114West Nile virus infection causes endocytosis of a specific subset of tight junction membrane proteins
Q92782333YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway
Q42483722ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability
Q33721589ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells
Q89009852ZO-1 protein is required for hydrogen peroxide to increase MDCK cell paracellular permeability in an ERK 1/2-dependent manner
Q37132493ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions
Q47206121Zinc ions regulate opening of tight junction favouring efflux of macromolecules via the GSK3β/snail-mediated pathway
Q35756679Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
Q47390338claudin-10 isoform expression and cation selectivity change with salinity in salt-secreting epithelia of Fundulusheteroclitus
Q54473221src family kinases regulate renal epithelial paracellular permeability barrier through an occludin-independent mechanism.

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