The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks

scientific article published on 3 April 2013

The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.466193
P932PMC publication ID3650414
P698PubMed publication ID23553632

P2093author name stringMarjan Gucek
Christina M Van Itallie
Angel Aponte
James Melvin Anderson
Amber Jean Tietgens
Karin Fredriksson
P2860cites workThe tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleusQ21284172
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strandsQ22008687
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseQ22253438
Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1Q22254323
Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilamentsQ24290826
Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161pQ24290988
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junctionQ24291966
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctionsQ24316928
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junctionQ24678766
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrationQ24682572
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinQ24683294
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesisQ27348924
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinasesQ27658948
PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identityQ28118990
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5Q28138959
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1Q28202074
Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding propertiesQ28202099
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signallingQ28204348
Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin CytoskeletonQ28204673
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptorsQ28207179
The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCFQ28217069
Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAPQ28241192
Physiology and function of the tight junctionQ28270069
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled familyQ28285378
Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouseQ28287031
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctionsQ28509484
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctionsQ28511375
Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cellsQ28565673
JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulinQ28591650
Reorganizing the protein space at the Universal Protein Resource (UniProt)Q29547338
Cell biological characterization of a multidomain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform.Q30010154
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonQ30157199
The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signalingQ30431153
Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assemblyQ30439656
Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.Q30441253
Dimerization of the scaffolding protein ZO-1 through the second PDZ domainQ33247516
A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctionsQ33292672
Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.Q33317834
Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epitheliumQ33556272
Molecular basis of the core structure of tight junctionsQ33685399
Cell polarity in eggs and epithelia: parallels and diversityQ34118022
Cingulin, a new peripheral component of tight junctionsQ34172366
Signalling to and from tight junctionsQ34180670
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cellsQ34260840
Polarized sorting and trafficking in epithelial cellsQ34270230
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complexQ34279275
Nance-Horan syndrome protein, NHS, associates with epithelial cell junctionsQ34522000
PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cellsQ34886029
Gene expression databases for kidney epithelial cellsQ35787433
Regulation of epithelial permeability by the actin cytoskeletonQ35846716
Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contactsQ35856912
Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebratesQ35913686
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.Q36166916
Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.Q36172886
The terminal web. A reevaluation of its structure and functionQ36203784
Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cellsQ36218386
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor proteinQ36233880
Tight Junction Pore and Leak Pathways: A Dynamic DuoQ36305755
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeletonQ36322073
Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.Q36546994
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.Q36779763
The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin.Q37204309
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctionsQ37524262
ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis.Q38016497
Cell polarity as a regulator of cancer cell behavior plasticityQ38033611
ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS developmentQ38342608
Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contactsQ39370787
Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasivenessQ39634040
ASPP2 regulates epithelial cell polarity through the PAR complex.Q39682152
Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarizationQ39734201
The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesisQ39772059
Annexin A2 heterotetramer: role in tight junction assemblyQ40561982
Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1.Q40700804
Association of frabin with specific actin and membrane structures.Q40738345
Localization of membrane-associated guanylate kinase (MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cellsQ40908844
Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesionQ41428100
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epitheliumQ42614771
Identification and characterization of human ARHGAP23 gene in silico.Q42631528
Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration.Q42766121
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsQ42796669
Dynein binds to beta-catenin and may tether microtubules at adherens junctions.Q43754950
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Q45345068
Differential phosphorylation of occludin and tricellulin by CK2 and CK1.Q45963244
Optimized proteomic analysis on gels of cell-cell adhering junctional membrane proteinsQ46641610
Molecular analyses of tight junction physiology: insights and paradoxesQ47977689
The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1.Q52941644
Tight junction formation in cultured epithelial cells (MDCK).Q54457086
Clathrin-mediated endocytosis regulates occludin, and not focal adhesion, distribution during epithelial wound healingQ83085522
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)13775-13788
P577publication date2013-04-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks
P478volume288