Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

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Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.103.3.755
P8608Fatcat IDrelease_xhmyzxv6u5dgxkjqs6t5cwa2oi
P3181OpenCitations bibliographic resource ID907548
P932PMC publication ID2114282
P698PubMed publication ID3528172
P5875ResearchGate publication ID270807553

P50authorJanet D SilicianoQ89850092
P2093author name stringM S Mooseker
D A Goodenough
B R Stevenson
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Variations in tight and gap junctions in mammalian tissuesQ24682450
A fine structural analysis of intercellular junctions in the mouse liverQ24682661
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A domain-specific marker for the hepatocyte plasma membrane. III. Isolation of bile canalicular membrane by immunoadsorptionQ30494580
Transepithelial transport in cell cultureQ34997137
Identification and organization of the components in the isolated microvillus cytoskeletonQ36201009
Occluding junctions and cytoskeletal components in a cultured transporting epitheliumQ36202080
Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domainsQ36206553
Isolation of rat hepatocyte plasma membranes. II. Identification of membrane-associated cytoskeletal proteinsQ36206585
Preparation, characterization, and localization of antisera against bovine MP26, an integral protein from lens fiber plasma membraneQ36207126
Participation of plasma membrane proteins in the formation of tight junctions by cultured epithelial cells.Q36207161
A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domainQ36207387
Establishment of plasma membrane domains in hepatocytes. I. Characterization and localization to the bile canaliculus of three antigens externally oriented in the plasma membraneQ36208575
Reactivation of intestinal epithelial cell brush border motility: ATP-dependent contraction via a terminal web contractile ringQ36209328
Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liverQ36210152
Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterizationQ36210591
A domain-specific marker for the hepatocyte plasma membrane. II. Ultrastructural localization of leucine aminopeptidase to the bile canalicular domain of isolated rat liver plasma membranesQ36210623
Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies.Q36212870
Endogenous and exogenous domain markers of the rat hepatocyte plasma membraneQ36212958
Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulinQ36213628
Immunoelectron microscope studies of membrane-microfilament interactions: distributions of alpha-actinin, tropomyosin, and vinculin in intestinal epithelial brush border and chicken gizzard smooth muscle cellsQ36630569
The membrane skeleton of human erythrocytes and its implications for more complex cellsQ39614643
Cell adhesion and the molecular processes of morphogenesisQ39826658
On tight-junction structureQ40264285
Polarized monolayers formed by epithelial cells on a permeable and translucent supportQ41233493
Tight junctions in the choroid plexus epithelium. A freeze-fracture study including complementary replicasQ41249770
Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cellsQ41468891
A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptideQ41498808
Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice.Q44094636
Ankyrin and synapsin: spectrin-binding proteins associated with brain membranesQ48582079
Further observations on the fine structure of freeze-cleaved tight junctions.Q53816155
Occluding junctions in MDCK cells: modulation of transepithelial permeability by the cytoskeleton.Q54525307
Occluding junctions in cultured epithelial monolayers.Q54538173
Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins.Q54548198
Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody.Q55062706
Determination of protein: A modification of the lowry method that gives a linear photometric responseQ56680361
Evidence for the lipidic nature of tight junction strandsQ59087871
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)755-66
P577publication date1986-09-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleIdentification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia
P478volume103

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Q49705802Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway
Q33703894Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1.
Q36685450Gap junctions and cell polarity: Connexin32 and connexin43 expressed in polarized thyroid epithelial cells assemble into separate gap junctions, which are located in distinct regions of the lateral plasma membrane domain
Q34236239Gap junctions in development—a perspective
Q34520959Gastrointestinal mucosal barrier function and diseases.
Q35333767Ginseng total saponin improves podocyte hyperpermeability induced by high glucose and advanced glycosylation endproducts
Q33620691Glomerular changes and alterations of zonula occludens-1 in the kidneys of Plasmodium falciparum malaria patients
Q46077153Glucocorticoid down-regulation of RhoA is required for the steroid-induced organization of the junctional complex and tight junction formation in rat mammary epithelial tumor cells
Q41608249Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells
Q37221402Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro
Q40627232Glucocorticoids Control β-Catenin Protein Expression and Localization through Distinct Pathways that Can Be Uncoupled by Disruption of Signaling Events Required for Tight Junction Formation in Rat Mammary Epithelial Tumor Cells
Q40035379Glutathione-S-transferase protects against oxidative injury of endothelial cell tight junctions
Q38141958Glycoconjugates and cell surface interactions in pre- and peri-implantation mammalian embryonic development
Q35671844Harvest and primary culture of the murine aldosterone-sensitive distal nephron
Q38995137Helicobacter pylori dwelling on the apical surface of gastrointestinal epithelium damages the mucosal barrier through direct contact
Q35816803Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis
Q46348536Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers
Q40621023Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity
Q84434171Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1
Q48142418Heterogeneous vascular permeability and alternative diffusion barrier in sensory circumventricular organs of adult mouse brain
Q28565629High-glucose and advanced glycosylation end products increased podocyte permeability via PI3-K/Akt signaling
Q41890457Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells
Q34211271Histamine, ZO-1 and increased blood-retinal barrier permeability in diabetic retinopathy
Q36046422Histidine Prevents Cu-Induced Oxidative Stress and the Associated Decreases in mRNA from Encoding Tight Junction Proteins in the Intestine of Grass Carp (Ctenopharyngodon idella).
Q51230885Histochemical analyses of living mouse liver under different hemodynamic conditions by "in vivo cryotechnique".
Q33715804Homeostasis of the gut barrier and potential biomarkers
Q36232809Hormonal regulation of the polarized function and distribution of Na/H exchange and Na/HCO3 cotransport in cultured mammary epithelial cells
Q36267888Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue
Q41648049Human airway epithelial tight junctions
Q24290426Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly
Q43116931Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells
Q37527202Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice
Q54360931Hypertonic stress promotes the upregulation and phosphorylation of zonula occludens 1.
Q39206409Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System
Q41844055IFITM1 is a tight junction protein that inhibits hepatitis C virus entry
Q45233841ILDR1 is important for paracellular water transport and urine concentration mechanism.
Q24307775Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1
Q35747176Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus
Q58994624Identification of PDZ Domain Containing Proteins Interacting with 1.2 and PMCA4b
Q37487429Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.
Q36218624Identification of a basic protein of Mr 75,000 as an accessory desmosomal plaque protein in stratified and complex epithelia.
Q36255868Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver
Q28283564Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells
Q44551575Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro
Q38331954Identification of the region of alpha-catenin that plays an essential role in cadherin-mediated cell adhesion
Q38521778Immortalization of rat eustachian tube epithelial cells by adenovirus 12-simian virus 40 hybrid virus
Q40823957Immortalization of rat middle ear epithelial cells by adeno 12-SV40 hybrid virus
Q64982692Implications of AMPK in the Formation of Epithelial Tight Junctions.
Q33827550In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.
Q33992629In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC).
Q46085888Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease.
Q92092623Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
Q41018428Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia
Q39628237Increasing of Blood-tumor Barrier Permeability through Paracellular Pathway by Low-frequency Ultrasound Irradiation In Vitro
Q47162035Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
Q36951581Induction of blood-brain barrier endothelial cell differentiation
Q41687320Influence of PMA and a low extracellular Ca2+ concentration on the development of the Na+-dependent hexose carrier in LLC-PK1 cells
Q41626078Influence of metabolic inhibitors on the degradation of tight junctions in HT29 cells
Q40809595Influence of retinoic acid on human gingival epithelial barriers
Q28238713Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc
Q41612546Interendothelial junctions: structure, signalling and functional roles.
Q35323742Intermediate filaments in Sertoli cells
Q35942675Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier
Q42072156Intracellular Golgi Complex organization reveals tissue specific polarity during zebrafish embryogenesis
Q28571227Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells
Q24678389Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments
Q36523471Involvement of cell junctions in hepatocyte culture functionality
Q30157022Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells
Q38688723Is RPMI 2650 a Suitable In Vitro Nasal Model for Drug Transport Studies?
Q46471778Ischemia-reperfusion injury stimulates gelatinase expression and activity in kidney glomeruli
Q33557175Isolation and characterization of the apical surface of polarized Madin-Darby canine kidney epithelial cells
Q53781951Isolation, culture and characterization of primary mouse RPE cells.
Q28591650JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin
Q24296715JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration
Q28208782JEAP, a novel component of tight junctions in exocrine cells
Q28771500JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet
Q47771280Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development.
Q24669667Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
Q22254323Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1
Q24682572Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
Q39578831Junctional communication and cellular differentiation.
Q35046911Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation
Q30384261Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity.
Q39646701K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development
Q73120648Keratin subunit expression in human cultured melanocytes and mouse neural crest cells without formation of filamentous structures
Q36218695Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. I. Biochemical analysis
Q48819440Krüppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5.
Q34450832L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets
Q35694999Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury
Q42725230Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress
Q24679811Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
Q37965865Lipids in gap junction assembly and function
Q28591972Lipolysis-stimulated lipoprotein receptor: a novel membrane protein of tricellular tight junctions
Q28251678Localization and differential expression of two isoforms of the tight junction protein ZO-1
Q34345365Localization and expression of zonula occludins-1 in the rabbit corneal epithelium following exposure to benzalkonium chloride
Q36221082Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells
Q35239339Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome
Q44814259Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions
Q46068846Lower expression of tight junction protein 1 gene and increased FOXP3 expression in the small bowel mucosa in coeliac disease and associated type 1 diabetes mellitus
Q46697366MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin
Q28771389MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density
Q37565430MT2-MMP induces proteolysis and leads to EMT in carcinomas
Q46196382Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions
Q36970865Making and breaking contacts: the cellular biology of cadherin regulation
Q24683327Manner of interaction of heterogeneous claudin species within and between tight junction strands
Q34017761Mechanisms of gap junction traffic in health and disease
Q41245385Microtubule dynamic turnover is suppressed during polarization and stimulated in hepatocyte growth factor scattered Madin-Darby canine kidney epithelial cells
Q64097325Modulation of microbial communities and mucosal gene expression in chicken intestines after galactooligosaccharides delivery In Ovo
Q50423780Molecular Regulation of Sprouting Angiogenesis
Q73489985Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view
Q41307210Molecular and cellular mechanisms of pneumococcal meningitis
Q77110276Molecular and cellular permeability control at the blood-brain barrier
Q26864785Molecular aspects of tight junction barrier function
Q33685399Molecular basis of the core structure of tight junctions
Q36233880Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein
Q28510848Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
Q40896655Molecular decipherment of Rho effector pathways regulating tight-junction permeability
Q41402732Molecular environment of ZO-1 in epithelial and non-epithelial cells
Q36232347Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.
Q38139823Monocyte chemoattractant protein-1 and the blood-brain barrier
Q46068032Morphological observations of rat corneal endothelial cells after exposure to ozonated solution
Q37810004Morphology and Properties of Brain Endothelial Cells
Q36951564Morphology of glial blood-brain barriers
Q28203316Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule
Q28210051Multifunctional strands in tight junctions
Q36529343Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras
Q33734527Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin
Q30513859Myosin-X functions in polarized epithelial cells
Q90067893N-Glycosylation of the voltage-gated sodium channel β2 subunit is required for efficient trafficking of NaV1.5/β2 to the plasma membrane
Q34023780N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells.
Q40181305NHE-RF1 protein rescues DeltaF508-CFTR function.
Q81630691Na+/K+ -ATPase regulates tight junction formation and function during mouse preimplantation development
Q59806591Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
Q35653077Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Q37791921New aspects of the molecular constituents of tissue barriers
Q89533672New insight into podocyte slit diaphragm, a therapeutic target of proteinuria
Q35548957Nitric Oxide/Nitric Oxide Synthase, Spermatogenesis, and Tight Junction Dynamics1
Q28508837Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein
Q24680419OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes
Q35132145Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
Q77403435Occludin and the functions of tight junctions
Q28202259Occludin expression in microvessels of neoplastic and non-neoplastic human brain
Q34043395Occludin is required for cytokine-induced regulation of tight junction barriers
Q31146058Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2.
Q36289162Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
Q24657666Occludin: a novel integral membrane protein localizing at tight junctions
Q84589578Ocular irritancy assessment of cosmetics formulations and ingredients: fluorescein leakage test
Q52185052Oogenetic and zygotic gene expression directing early bovine embryogenesis: a review.
Q40941485Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cells
Q64265564Oral Mucosal Epithelial Cells
Q33515113Oral administration of mesalazine protects against mucosal injury and permeation in dextran sulfate sodium-induced colitis in rats
Q37118549Organization of multiprotein complexes at cell-cell junctions
Q36178225Organotypic liver culture models: meeting current challenges in toxicity testing
Q35411064Osmotic pressure-adaptive responses in the eye tissues of rainbow smelt (Osmerus mordax).
Q41517696Oxidative stress causes a protein kinase C-independent increase of paracellular permeability in an in vitro epithelial model
Q46570774Oxidative stress-induced disruption of epithelial and endothelial tight junctions.
Q21136176PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin
Q37159206PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
Q28279500Paracellular drug absorption enhancement through tight junction modulation
Q92126517Parental centrioles are dispensable for deuterosome formation and function during basal body amplification
Q48535215Pattern of glucose transporter (Glut 1) expression in embryonic brains is related to maturation of blood-brain barrier tightness
Q41988859Pcbs and tight junction expression
Q38089668Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier
Q68440358Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vitro
Q42804010Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance
Q24291796Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells
Q35970328Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation
Q35965590Plugging the leaks
Q41561344Polarized distribution of gamma interferon-stimulated MHC antigens and transferrin receptors in a clonal cell line isolated from Fisher rat thyroid (FRT cells).
Q30897208Poly-L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro
Q46592570Polychlorinated biphenyls impair blood-brain barrier integrity via disruption of tight junction proteins in cerebrum, cerebellum and hippocampus of female Wistar rats: neuropotential role of quercetin
Q42436788Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells
Q41104367Possible involvement of phosphorylation of occludin in tight junction formation
Q36281798Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein
Q46459829Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9.
Q42546612Primary culture of porcine nonpigmented ciliary epithelium.
Q33309955Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Q47584454Process of tight junction recovery in the injured vocal fold epithelium: Morphological and paracellular permeability analysis.
Q41626064Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines
Q38911426Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions
Q34027222Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption.
Q53399282Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells.
Q36869590Protein Sorting in Polarized Epithelial Cells
Q34081941Protein kinase C activation has distinct effects on the localization, phosphorylation and detergent solubility of the claudin protein family in tight and leaky epithelial cells
Q41631117Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells
Q36382782Protein zero, a nervous system adhesion molecule, triggers epithelial reversion in host carcinoma cells
Q28544676Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks
Q39738806Protocadherin of the liver, kidney, and colon associates with detergent-resistant membranes during cellular differentiation.
Q92785707R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing
Q24311646Rab13 mediates the continuous endocytic recycling of occludin to the cell surface
Q24673790Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
Q24557505RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity
Q41687919Rapid aggregation and tight junction formation in single cell suspensions of tumor cells after very low dose trypsin treatment
Q28396273Reactive oxygen species in inflammation and tissue injury
Q38190079Recent progress in tight junction modulation for improving bioavailability
Q39788136Recombinant human elafin protects airway epithelium integrity during inflammation
Q33827829Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells
Q38978743Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals
Q51557204Regeneration of tracheal epithelium using mouse induced pluripotent stem cells.
Q36118459Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate
Q27304819Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis
Q38021500Regulation of epithelial proliferation by tight junction proteins
Q54107083Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone.
Q33306608Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2
Q40832397Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms
Q35544541Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct
Q39734201Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization
Q40607486Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis
Q34690508Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells
Q36091834Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures.
Q30900798Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene
Q52652372RhoA/rho kinase signaling reduces connexin43 expression in high glucose-treated glomerular mesangial cells with zonula occludens-1 involvement.
Q40883470Role of ATP7B in biliary copper excretion in a human hepatoma cell line and normal rat hepatocytes
Q92155709Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy
Q71686845Role of F-actin in the activation of Na(+)-K(+)-Cl- cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells
Q40620534Role of dentilisin in Treponema denticola epithelial cell layer penetration
Q38076279Role of the blood-brain barrier in the formation of brain metastases
Q46766045Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption
Q26863721Roles of adaptor proteins in podocyte biology
Q34340040Roles of cytoskeletal and junctional plaque proteins in nuclear signaling
Q33878942S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.
Q99624181SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis
Q44896653Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage
Q39407147Scaffolding proteins in the development and maintenance of the epidermal permeability barrier
Q39339775Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
Q39253834Schwann cell-derived desert hedgehog signals nerve sheath formation
Q36221176Selective anchoring in the specific plasma membrane domain: a role in epithelial cell polarity
Q36752066Sequential decrease in tight junctions as revealed by 7H6 tight junction-associated protein during rat hepatocarcinogenesis
Q35073616Sertoli cell tight junction dynamics: their regulation during spermatogenesis
Q28139380Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells
Q42528269Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions
Q42367534Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells.
Q40828152Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells
Q84590065Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neu
Q90439535Stem Cell-Derived Retinal Pigment Epithelial Layer Model from Adult Human Globes Donated for Corneal Transplants
Q94069687Sticking it out with tight junctions
Q36642527Stimulus-induced reorganization of tight junction structure: the role of membrane traffic
Q33771789Stress signaling in Drosophila
Q33562320Stretch and Shear Interactions Affect Intercellular Junction Protein Expression and Turnover in Endothelial Cells
Q33744924Structural and signalling molecules come together at tight junctions
Q27659196Structural basis for spectrin recognition by ankyrin
Q33914550Structural correlates of the transepithelial water transport
Q35242635Structure, regulation, and pathophysiology of tight junctions in the gastrointestinal tract
Q27653418Structures of the spectrin-ankyrin interaction binding domains
Q104289620Study on the Influencing Factors of Hypoglycemic Effect of Folate Targeted Polymersomes Encapsulating Insulin
Q47926576Study on the formation of specialized inter-Sertoli cell junctions in vitro
Q40941846Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells
Q92924119Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open Questions
Q51779617Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets.
Q24317634Symplekin, a novel type of tight junction plaque protein
Q27310572Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturation
Q53507564Syndecan-1 Acts in Synergy with Tight Junction Through Stat3 Signaling to Maintain Intestinal Mucosal Barrier and Prevent Bacterial Translocation.
Q34746651Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis-like intestinal injury
Q37994622Taking inflammatory bowel disease up a Notch
Q35855634Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery
Q40826335Targeting of an apical endosomal protein to endosomes in Madin-Darby canine kidney cells requires two sorting motifs
Q28088708Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury
Q36531120Temporal changes in the expression and distribution of adhesion molecules during liver development and regeneration
Q24336066The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy
Q37810007The Blood-Retinal Barrier: Structure and Functional Significance
Q34769606The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage
Q89552148The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium
Q36734066The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis
Q36832696The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks
Q38692787The Outflow Pathway: A Tissue With Morphological and Functional Unity.
Q39001731The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in Spheroid Screening Assays.
Q30176715The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain
Q28589887The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation
Q40039422The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane
Q92911291The Ussing chamber system for measuring intestinal permeability in health and disease
Q36322940The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
Q38480496The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells
Q28316929The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1
Q33619070The apical junctional complex in respiratory diseases
Q36273826The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells
Q24316289The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members
Q86905010The blood-brain barrier
Q41931942The calcium ionophore A23187 increases the tight-junctional permeability in rat liver
Q40869408The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
Q47935591The complete mouse nebulin gene sequence and the identification of cardiac nebulin
Q35629419The connexin43 carboxyl terminus and cardiac gap junction organization
Q24291966The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Q41069175The cytoplasmic juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant
Q42456422The discovery of epidermal tight junctions.
Q37708020The dual role of zonula occludens (ZO) proteins
Q41523151The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions
Q91910512The effectiveness of traditional Japanese medicine Goshajinkigan in irradiation-induced aspermatogenesis in mice
Q39546381The epithelial tight junction: structure, function and preliminary biochemical characterization
Q37564410The gap junction family: structure, function and chemistry
Q30159960The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB.
Q39376508The inner blood-retinal barrier: Cellular basis and development
Q28567260The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain
Q37295472The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.
Q40903764The molecular organization of tight junctions
Q39071909The mucosal barrier at a glance.
Q34103481The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis
Q41033973The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin
Q34745959The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components
Q82263885The role of EFA6, exchange factor for Arf6, for tight junction assembly, functions, and interaction with the actin cytoskeleton
Q33619118The role of nuclear factor I-C in tooth and bone development.
Q28289033The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex
Q38537520The roles of signaling pathways in epithelial-to-mesenchymal transition of PVR.
Q43743715The second PDZ domain of zonula occludens-1 is dispensable for targeting to connexin 43 gap junctions
Q30654463The spatial organization of apical junctional complex-associated proteins in feline and human corneal endothelium
Q40926839The structural and functional polarity of the hepatic human/rat hybrid WIF-B is a stable and dominant trait
Q36222150The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium
Q30409921The surprising dynamics of scaffolding proteins.
Q33786878The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice
Q30175138The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression
Q36223791The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium
Q24316928The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions
Q28211466The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B
Q36660697The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state
Q35777543The tight junction: a multifunctional complex
Q28255715The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation
Q28202664The tumor suppressor protein TSLC1 is involved in cell-cell adhesion
Q36667280The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing
Q36211521Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology
Q39560784Three-dimensional culture of an ovine pulmonary adenocarcinoma-derived cell line results in re-expression of surfactant proteins and Jaagsiekte sheep retrovirus
Q67956104Three-dimensional model of tight junction fibrils based on freeze-fracture images
Q36305755Tight Junction Pore and Leak Pathways: A Dynamic Duo
Q92354281Tight Junctions of the Outer Blood Retina Barrier
Q36015680Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells
Q52088623Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Q34813431Tight junction proteins in the canine epidermis: a pilot study on their distribution in normal and in high IgE-producing canines
Q58098084Tight junction proteins1This review is dedicated to the memory of Thomas Kreis.1
Q37118065Tight junction proteins: from barrier to tumorigenesis.
Q36221153Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance
Q28203688Tight junction-related protein expression and distribution in human corneal epithelium
Q44478801Tight junctions and mucin mRNA in BEAS-2B cells
Q37139446Tight junctions and the modulation of barrier function in disease
Q38058856Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation
Q33674271Tight junctions in salivary epithelium
Q35096872Tight junctions in the skin
Q28145432Tight junctions of the blood-brain barrier
Q24292730Tight junctions of the blood-brain barrier: development, composition and regulation
Q38879992Tight junctions: from simple barriers to multifunctional molecular gates
Q36400271Tight junctions: molecular architecture and function
Q40953854Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney
Q53516856Tissue heme oxygenase-1 exerts anti-inflammatory effects on LPS-induced pulmonary inflammation.
Q42495862Tissue-Specific stem cell differentiation in an in vitro airway model
Q28581494Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands
Q26863424Tonic regulation of vascular permeability
Q36219769Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions
Q41092749Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations
Q38734561Trafficking and localisation to the plasma membrane of Nav 1.5 promoted by the β2 subunit is defective due to a β2 mutation associated with Brugada syndrome.
Q34790810Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation
Q41136241Transforming growth factor beta1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis
Q41900830Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes
Q38342639Transmembrane assemblage of the photoreceptor connecting cilium and motile cilium transition zone contain a common immunologic epitope
Q27690256Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?
Q38482451Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology
Q40597861Tumor necrosis factor alpha disrupts tight junction assembly
Q44364560Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes
Q24321386Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain
Q40262405Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.
Q36219888Type I collagen gel induces Madin-Darby canine kidney cells to become fusiform in shape and lose apical-basal polarity
Q35087817Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion
Q46009466Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.
Q36236381V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift
Q43512732VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly
Q37997013Vascular disruption and the role of angiogenic proteins after spinal cord injury
Q37534948Vascular dysfunction in the diabetic placenta: causes and consequences.
Q36435638Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
Q40874328Virus infection of polarized epithelial cells
Q47839616Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula
Q36385735Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair?
Q24657706WIF-B cells: an in vitro model for studies of hepatocyte polarity
Q26995346Xin proteins and intercalated disc maturation, signaling and diseases
Q34070506ZO proteins redundantly regulate the transcription factor DbpA/ZONAB
Q33721589ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells
Q46013923ZO-1 and the spatial organization of gap junctions and glutamate receptors in the outer plexiform layer of the mammalian retina.
Q90641015ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells
Q34600431ZO-1 determines adherens and gap junction localization at intercalated disks
Q38734544ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.
Q27314931ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape
Q35879377ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells
Q37132493ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions
Q30157199ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
Q30483283ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens
Q24683294ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
Q40383439Zonula occludens-1 (ZO-1) redistribution is involved in the regulation of cell dissociation in pancreatic cancer cells.
Q34148181Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion
Q37524262Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
Q40240304aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion
Q38761856alpha-catenin-independent recruitment of ZO-1 to nectin-based cell-cell adhesion sites through afadin
Q30168747hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions
Q28235003hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
Q36518967p38 MAPK mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cells

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