Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair?

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Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FPHYS.2012.00424
P932PMC publication ID3493883
P698PubMed publication ID23162470
P5875ResearchGate publication ID233539656

P50authorAna A. BaburamaniQ38326231
P2093author name stringDavid W Walker
C Joakim Ek
Margie Castillo-Melendez
P2860cites workThe effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal ratsQ80313211
Expression of erythropoietin and its receptor in the brain of late-gestation fetal sheep, and responses to asphyxia caused by umbilical cord occlusionQ80941039
Angiogenic pathways in diabetic retinopathyQ81111901
Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal ratsQ81412185
[Value of magnetic resonance imaging in the early evaluation of prognosis for hypoxic-ischemic encephalopathy in full-term infants]Q81443742
VEGF protects brain against focal ischemia without increasing blood--brain permeability when administered intracerebroventricularlyQ81649097
Dexamethasone pre-treatment protects brain against hypoxic-ischemic injury partially through up-regulation of vascular endothelial growth factor A in neonatal ratsQ83322860
Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhereQ24298375
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesisQ24313372
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Pericytes are required for blood-brain barrier integrity during embryogenesisQ24627396
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrationQ24682572
Junctions between intimately apposed cell membranes in the vertebrate brainQ24682725
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
The role of pericytes in blood-vessel formation and maintenanceQ24683881
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesisQ24684263
Mechanisms of excitotoxicity in neurologic diseasesQ28187939
The JAM family of junctional adhesion moleculesQ28205895
Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family membersQ28209920
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alphaQ28259513
In vivo expression of mRNAs encoding hypoxia-inducible factor 1Q28286675
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesisQ28300359
Isolation of putative progenitor endothelial cells for angiogenesisQ28302884
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiationQ28510000
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1Q28513759
Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferationQ28575940
Binding of laminin to type IV collagen: a morphological studyQ28645694
Vascular endothelial growth factor is a secreted angiogenic mitogenQ28646475
Rapid disruption of an astrocyte interaction with the extracellular matrix mediated by integrin alpha 6 beta 4 during focal cerebral ischemia/reperfusionQ36853328
From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain.Q36886404
Apoptotic mechanisms in the immature brain: involvement of mitochondriaQ36907496
Induction of blood-brain barrier endothelial cell differentiationQ36951581
Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxiaQ36986801
Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)Q37080750
Blood brain barrier in hypoxic-ischemic conditionsQ37090115
HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model.Q37090306
Barriers in the brain: a renaissance?Q37159965
Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injuryQ37171406
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesisQ37271066
Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke.Q37320339
Vascular endothelial growth factor in central nervous system injuries - a vascular growth factor getting nervous?Q37320342
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.Q37361862
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
The role of hypoxia-inducible transcription factors in the hypoxic neonatal brainQ37461747
Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in miceQ37468643
Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infantsQ37475012
Periventricular white matter damage in the hypoxic neonatal brain: role of microglial cellsQ37476119
Implications of vascular endothelial growth factor for postischemic neurovascular remodeling.Q37572370
The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injuryQ37604526
Intraventricular hemorrhage in premature infants: mechanism of diseaseQ37611514
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and diseaseQ37781281
Neuronal death and oxidative stress in the developing brainQ37797501
Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular diseaseQ37818446
Stem cells and the vasculatureQ37953780
Barriers in the developing brain and NeurotoxicologyQ37971320
Changing pattern of perinatal brain injury in term infants in recent yearsQ37977572
Neuroprotective mechanisms of hypothermia in brain ischaemiaQ37986997
Antioxidant therapies: a potential role in perinatal medicine.Q37989302
Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?Q38011443
Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA.Q38355340
Intraventricular hemorrhage and brain injury in the premature infant. Neuropathology and pathogenesis.Q38657901
Nutrient transport and the blood-brain barrier in developing animals.Q39442737
Mechanisms of angiogenesisQ29547485
Angiogenesis in health and diseaseQ29614541
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivoQ29614729
Vascular-specific growth factors and blood vessel formationQ29614780
Structure and function of the blood-brain barrierQ29615699
The blood-brain barrier: an overview: structure, regulation, and clinical implicationsQ29616839
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectinQ29617865
Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouseQ30817739
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brainQ30936721
Hypoxic-ischemic brain injury in the term infant-current conceptsQ30971761
Brain injury in the term infantQ30982117
Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.Q31153090
VEGF localisation in diabetic retinopathyQ32035851
Effect of mild hypothermia on angiogenesis in rats with focal cerebral ischemiaQ33290786
Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brainQ33425965
Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheepQ33589149
Cellular mechanisms of hypoxic injury in the developing brainQ33608628
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptorsQ33615441
HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia.Q33646635
Dynamics of fetal circulatory responses to hypoxia and asphyxiaQ33700762
Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cellsQ33730124
Extracellular matrix degradation by metalloproteinases and central nervous system diseasesQ33737455
Vascular responses to hypoxia and ischemiaQ33739281
Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of strokeQ33757424
Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursorsQ33887795
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesisQ33900066
Mechanisms of perinatal brain injuryQ33913455
Do neurons in the vertebrate CNS migrate on laminin?Q33931210
Angiogenesis: new insights and therapeutic potentialQ33950625
Development of the blood-brain barrierQ33968144
Pericytes: pluripotent cells of the blood brain barrierQ34013140
Newborn rabbit blood-brain barrier is selectively permeable and differs substantially from the adultQ34057546
Effect of prenatal glucocorticoids on cerebral vasculature of the developing brainQ34059834
CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2.Q34063593
Pericytes in the microvasculatureQ34063666
Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.Q36736945
Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginineQ36817052
Understanding the biology of angiogenesis: review of the most important molecular mechanismsQ36842196
Hypoxic-ischemic injury in the immature brain--key vascular and cellular playersQ36843720
Immunolocalization of tight junction proteins in the adult and developing human brainQ47280497
Relationship between antenatal steroid administration and grades III and IV intracranial hemorrhage in low birth weight infants. The NICHD Neonatal Research NetworkQ47351310
Circulating CD34-positive cells provide an index of cerebrovascular functionQ47377874
A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouseQ47743059
Vascular endothelial growth factor in brains with periventricular leukomalaciaQ47772138
Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat.Q47772427
Brain injury and intrauterine deathQ47878732
Sustained hypoxia-ischemia results in reactive nitrogen and oxygen species production and injury in the premature fetal rabbit brainQ47964132
VEGF induces hyperpermeability by a direct action on endothelial cells.Q48014396
Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesisQ48117290
Biphasic edema after hypoxic-ischemic brain injury in neonatal rats reflects early neuronal and late glial damageQ48121122
Subcortical leukomalacia. Relationship to development of the cerebral sulcus and its vascular supplyQ48178222
Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infantsQ80055266
The role of vascular endothelial growth factor in blood vessel formationQ80120173
An integrated model for haemorrhagic and ischaemic lesions in the newborn brainQ48178713
Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarctQ48182992
Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation.Q48195666
Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat.Q48199790
VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway.Q48209449
Microangiography and vascular permeability of the subependymal matrix in the premature infantQ48213507
Angiogenic inhibition reduces germinal matrix hemorrhageQ48221437
Development of Cerebrovascular Architecture and Its Relationship to Periventricular LeukomalaciaQ48231451
Pathophysiological aspects of brain edemaQ48233218
Developmental characteristics of vessel density in the human fetal and infant brainsQ48244479
Characterization of microvascular basal lamina damage and blood-brain barrier dysfunction following subarachnoid hemorrhage in ratsQ48271908
Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia.Q48272602
The fine structure of blood vessels of the telencephalic germinal matrix in the human fetusQ48273844
Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus.Q48288349
Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced cerebral edemaQ48314568
Structural characteristics and barrier properties of the choroid plexuses in developing brain of the opossum (Monodelphis Domestica).Q48324045
Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat.Q48327255
VEGF expression is developmentally regulated during human brain angiogenesisQ48358455
Antenatal glucocorticoid, magnesium exposure, and the prevention of brain injury of prematurityQ48373812
Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesisQ48373846
Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat.Q48395559
Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellumQ48420604
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.Q48421828
Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in ratsQ48428464
Blood-brain barrier integrity and brain water and electrolytes during hypoxia/hypercapnia and hypotension in newborn pigletsQ48432242
Local blood-brain barrier in the newborn rabbit: postnatal changes in alpha-aminoisobutyric acid transfer within medulla, cortex, and selected brain areasQ48434924
Morphometric analysis of CNS microvascular endotheliumQ48473408
Developmental change in type VI collagen in human cerebral vesselsQ48483177
Hypoxic damage to the periventricular white matter in neonatal brain: role of vascular endothelial growth factor, nitric oxide and excitotoxicityQ48492190
Involvement of MMPs in delayed neuronal death after global ischemia.Q48498146
Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxiaQ48508330
Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytesQ48523881
Acute and chronic increases in excitability in rat hippocampal slices after perinatal hypoxia In vivoQ48531318
Effects of acute hyperosmolality on blood-brain barrier function in ovine fetuses and lambsQ48544012
Role of extracellular proteins in the dynamics of vasogenic brain edemaQ48553091
Gestational changes in the germinal matrix of the normal rhesus monkey fetusQ48557463
Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infantsQ48575398
Vulnerability to cerebral hypoxic-ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood-brain barrierQ48594689
The fate and fine structure of fragments of blood vessels in CNS tissue culturesQ48598052
Role of vascular endothelial growth factor in blood-brain barrier breakdown and angiogenesis in brain trauma.Q48650822
Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brainQ48705739
Fibronectin promotes brain capillary endothelial cell survival and proliferation through alpha5beta1 and alphavbeta3 integrins via MAP kinase signallingQ48707747
Endothelin-1 as a mediator of endothelial cell-pericyte interactions in bovine brain capillariesQ48738608
Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal strokeQ48764284
Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matterQ48765099
Imaging patterns of brain injury in term-birth asphyxiaQ48774169
Beagle pup germinal matrix maturation studiesQ48778810
Absence of neuronal damage after umbilical cord occlusion of 10, 15, and 20 minutes in midgestation fetal sheepQ48787555
Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adultsQ48843572
Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in ratsQ48852577
Vascular endothelial growth factor in neonates with perinatal asphyxia.Q48877688
Role of the CNS microvascular pericyte in the blood-brain barrierQ34067528
Histochemical study of the differentiation of microglial cells in the developing human cerebral hemispheres.Q34083012
Laminin–a glycoprotein from basement membranesQ34083862
Potential biomarkers for hypoxic-ischemic encephalopathyQ34091662
Functions of the VEGF/VEGF receptor system in the vascular system.Q34113202
Origin and timing of brain lesions in term infants with neonatal encephalopathy.Q34181815
Molecular architecture of basement membranesQ34205360
The Human Periventricular Arterial Blood Supply and the Anatomy of Cerebral InfarctionsQ34229070
Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain InjuryQ34457628
Reactive species mechanisms of cellular hypoxia-reoxygenation injuryQ34491567
Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disordersQ34611022
Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal strokeQ34673506
Lipid composition of the normal human brain: gray matter, white matter, and myelinQ34706165
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation.Q34957102
The injury response in the term newborn brain: can we neuroprotect?Q35088239
Cerebral blood flow heterogeneity in preterm sheep: lack of physiologic support for vascular boundary zones in fetal cerebral white matterQ35114683
Cerebral microvessel responses to focal ischemiaQ35193869
New roles for VEGF in nervous tissue--beyond blood vesselsQ35773796
Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemiaQ35809808
Trends in perinatal mortality and cerebral palsy in Western Australia, 1967 to 1985Q35822097
Determining the contribution of asphyxia to brain damage in the neonateQ35828170
The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death.Q35851325
Hypoxia-ischemia in the immature brainQ35857983
Erythropoietin and the hypoxic brainQ35858017
Reactive oxygen species in the cerebral circulation: physiological roles and therapeutic implications for hypertension and strokeQ35904817
Vascular endothelial growth factor and angiogenesisQ35985850
Mechanisms of hypoxic-ischemic injury in the term infantQ36031261
Effects of maternal treatment with corticosteroids on tight junction protein expression in the cerebral cortex of the ovine fetus with and without exposure to in utero brain ischemiaQ36072853
The neuroprotective function of vascular endothelial growth factor (VEGF).Q36097023
Magnetic resonance techniques in the assessment of myelin and myelinationQ36114797
Predictors of outcome in perinatal arterial stroke: a population-based studyQ36190656
Animal models of germinal matrix hemorrhageQ36562293
Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusionQ36670336
Maturation-dependent vulnerability of perinatal white matter in premature birthQ36721657
Endothelial cell-astrocyte interactions. A cellular model of the blood-brain barrierQ39653396
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemiaQ39774417
Maintaining blood-brain barrier integrity: pericytes perform better than astrocytes during prolonged oxygen deprivation.Q39915333
Dexamethasone coordinately regulates angiopoietin-1 and VEGF: a mechanism of glucocorticoid-induced stabilization of blood-brain barrierQ39981254
The structure and function of the blood-brain barrierQ40168102
Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficientsQ40330530
Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat.Q40644718
Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1.Q40762316
The origin and nature of ramified and amoeboid microglia: a historical review and current conceptsQ40870421
Angiopoietin-1 protects the adult vasculature against plasma leakage.Q40890338
Laminin is induced in astrocytes of adult brain by injuryQ41565808
HIF-1alpha versus HIF-2alpha in endothelial cells and vascular functions: is there a master in angiogenesis regulation?Q41884005
Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insultQ42018761
Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat.Q42048570
Immunohistochemical evidence for the intracellular formation of basement membrane collagen (type IV) in developing tissuesQ42447925
Vascular endothelial growth factor and its high-affinity receptor (VEGFR-2) are highly expressed in the human forebrain and cerebellum during development.Q42466026
A potential role for erythropoietin in focal permanent cerebral ischemia in mice.Q42473313
Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brainQ42482810
Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in ratsQ42490887
Early pericyte response to brain hypoxia in cats: an ultrastructural studyQ42522604
Over expression of vascular endothelial growth factor and its receptor during the development of estrogen-induced rat pituitary tumors may mediate estrogen-initiated tumor angiogenesisQ42548790
Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitroQ43017958
Unilateral neonatal cerebral infarction in full term infantsQ43098256
Localization of microglia in the human fetal cervical spinal cordQ43501933
VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assemblyQ43512732
Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusionQ43697776
Effects of fetal asphyxia on brain cell structure and function: limits of toleranceQ43790058
Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemiaQ43937474
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.Q44166149
Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.Q44270070
Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathyQ44458057
Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contactsQ44654588
Lipid peroxidation, caspase-3 immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical cord occlusionQ44757260
Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early developmentQ44785344
CSF-brain permeability in the immature sheep fetus: a CSF-brain barrierQ45012996
Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte lossQ45028397
Circulating endothelial progenitor cells during human pregnancyQ45178368
VEGF disrupts the neonatal blood-brain barrier and increases life span after non-ablative BMT in a murine model of congenital neurodegeneration caused by a lysosomal enzyme deficiency.Q45875946
Perinatal stroke in term infants with neonatal encephalopathy.Q45933802
Brain lipid peroxidation and antioxidant levels in fetal lambs 72 hours after asphyxia by partial umbilical cord occlusion.Q45942331
Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury.Q45981153
Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brainQ46324373
Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood strokeQ46352189
Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathwayQ46428340
Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model.Q46432477
The role of vascular endothelial growth factor in wound healingQ46468770
Erythropoietin improves functional and histological outcome in neonatal strokeQ46477576
Developmental regulation of beta1 integrins during angiogenesis in the central nervous systemQ46571780
Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brainQ46660996
Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusionQ46678688
Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasoneQ46794941
Paucity of pericytes in germinal matrix vasculature of premature infants.Q46918337
Occludin as a possible determinant of tight junction permeability in endothelial cellsQ46990767
Development of blood-brain barrier tight junctions in the rat cortexQ48887823
Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cellsQ48960902
Influence of gestational age on the type of brain injury and neuromotor outcome in high-risk neonatesQ49037608
Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in miceQ49144166
CNS microvascular pericytes exhibit multipotential stem cell activity.Q51285884
Contribution of HIF-1alpha or HIF-2alpha to erythropoietin expression: in vivo evidence based on chromatin immunoprecipitation.Q51578552
Perspectives on neonatal hypoxia/ischemia-induced edema formation.Q51894025
New insights into the pathogenesis of perinatal hypoxic‐ischemic brain injuryQ51895678
Immunohistochemical study of the vasculature in the developing brain.Q52052782
The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion.Q52177454
Infarcts in the vascular distribution of the middle cerebral artery in preterm and fullterm infants.Q52195325
Circulating endothelial progenitor cells in preterm infants with bronchopulmonary dysplasia.Q52594464
White matter injury in term newborns with neonatal encephalopathy.Q53394860
Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats.Q53534081
The cerebral hemodynamic response to asphyxia and hypoxia in the near-term fetal sheep as measured by near infrared spectroscopy.Q54112705
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.Q55476886
Gestational Hypoxia Induces White Matter Damage in Neonatal Rats: A New Model of Periventricular LeukomalaciaQ56545863
The effect of moderate hypothermia in acute ischemic stroke on pericyte migration: an ultrastructural studyQ57101754
Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilationQ57198951
Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial CellsQ57283471
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1αQ59066890
Immunocytochemically stained vasopressin binding sites on blood vessels in the rat brainQ59449827
The Increase of Circulating Endothelial Progenitor Cells After Acute Ischemic Stroke Is Associated With Good OutcomeQ60589474
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flowQ61516466
Endothelial Colony Forming Cells and Mesenchymal Stem Cells are Enriched at Different Gestational Ages in Human Umbilical Cord BloodQ62590333
VEGF-Induced BBB Permeability is Associated with an MMP-9 Activity Increase in Cerebral ischemia: Both Effects Decreased by ANG-1Q63966767
Development of the blood-brain barrierQ67660260
Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodiesQ69044653
Vascular permeability factor, an endothelial cell mitogen related to PDGFQ69116052
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infantsQ69203798
Quantitative analysis of cerebral vessels in the newborn puppy: the structure of germinal matrix vessels may predispose to hemorrhageQ69242472
Adrenergic receptors on cerebral microvessels: pericyte contributionQ69938478
Temporal relationships of neuropathologic conditions caused by perinatal asphyxiaQ69972766
An immunocytochemical study of the germinal layer vasculature in the developing fetal brain using Ulex europaeus 1 lectinQ70413448
Modulation of the blood-brain barrier permeability in neonatal cytotoxic brain edema: laboratory and morphological findings obtained on newborn piglets with experimental pneumothoraxQ70639907
Migrating fetal astrocytes do not intravasate since they are excluded from blood vessels by vital basement membraneQ71617798
Role of angiogenesis in patients with cerebral ischemic strokeQ71643306
Cerebral palsy: the courts catch up with sad realitiesQ72477776
Neonatal stroke involving the middle cerebral artery in term infants: clinical presentation, EEG and imaging studies, and outcomeQ72630105
Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous systemQ72658005
Hypoxia activates the human placental vascular endothelial growth factor system in vitro and in vivo: up-regulation of vascular endothelial growth factor in clinically relevant hypoxic ischemia in birth asphyxiaQ73015047
Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusionQ73500489
Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclinQ74093564
Initial stage of vascular bed development in telencephalon of human embryoQ74289425
Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletionQ77068020
Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditionsQ77352961
Endothelial precursor cells in the peripheral blood of pregnant womenQ78554794
P921main subjecthypoxiaQ105688
P304page(s)424
P577publication date2012-11-09
P1433published inFrontiers in PhysiologyQ2434141
P1476titleVulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair?
P478volume3

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cites work (P2860)
Q41093315Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study
Q27025854Barrier mechanisms in neonatal stroke
Q39431098Blood-brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow
Q30845498Brain Oxygenation During Thoracoscopic Repair of Long Gap Esophageal Atresia
Q40308270Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia.
Q30720485Brain development after neonatal intermittent hyperoxia-hypoxia in the rat studied by longitudinal MRI and immunohistochemistry
Q30616090Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species
Q38644558Bright AIE Nanoparticles with F127 Encapsulation for Deep-Tissue Three-Photon Intravital Brain Angiography
Q36269620Cerebral microbleeds in a neonatal rat model
Q38197506Cerebral vascular regulation and brain injury in preterm infants
Q38771082Cerebral versus Ocular Visual Impairment: The Impact on Developmental Neuroplasticity.
Q35059244Comparison of intelligence, weight and height in children after general anesthesia with and without perioperative desaturation in non-cardiac surgery: a historical and concurrent follow-up study
Q30537801Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
Q90271627Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestation
Q28305318Detection of alpha II-spectrin breakdown products in the serum of neonates with congenital heart disease*
Q38634561Differential Effects of Antiretroviral Drugs on Neurons In Vitro: Roles for Oxidative Stress and Integrated Stress Response.
Q48874357Effect of oxygen inhalation on cerebral blood flow velocity in premature neonates
Q30405663Effects of prenatal hypoxia on schizophrenia-related phenotypes in heterozygous reeler mice: a gene × environment interaction study
Q34747263Epigenetic programming of hypoxic-ischemic encephalopathy in response to fetal hypoxia
Q36378034Fetal and neonatal iron deficiency but not copper deficiency increases vascular complexity in the developing rat brain
Q33586199Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis
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