The tight junction: a multifunctional complex

scientific article published on June 2004

The tight junction: a multifunctional complex is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPCELL.00558.2003
P698PubMed publication ID15151915

P2093author name stringEveline E Schneeberger
Robert D Lynch
P2860cites workInsulin and C-peptide secretion and kinetics in humans: direct and model-based measurements during OGTT.Q43762939
Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula OccludensQ43798217
Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulinQ43970551
Involvement of nectin in the localization of junctional adhesion molecule at tight junctionsQ44194178
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.Q44357555
Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight JunctionsQ58323630
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarizationQ58323641
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorptionQ22010191
Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctionsQ22010607
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseQ22253438
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cellsQ22253974
huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctionsQ22254287
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42Q22254751
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junctionQ24291966
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs LostQ24293049
Direct interaction of two polarity complexes implicated in epithelial tight junction assemblyQ24293221
The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cellsQ24299510
Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell PolarityQ24300954
Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escapeQ24307684
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor proteinQ36233880
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPasesQ36256190
The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cellsQ36276564
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctionsQ36289162
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cellsQ36316586
The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell densityQ36322940
Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeabilityQ36324231
The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.Q37295472
Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.Q37487429
Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1.Q39535911
The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus.Q39561321
NZO-3 expression causes global changes to actin cytoskeleton in Madin-Darby canine kidney cells: linking a tight junction protein to Rho GTPasesQ39788587
Paracellular ion channel at the tight junctionQ40231113
Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.Q40643877
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeationQ40666802
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressorsQ40680001
PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.Q40782848
Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanismsQ40832397
Exogenous expression of the amino-terminal half of the tight junction protein ZO-3 perturbs junctional complex assemblyQ40842719
A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarityQ40862977
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junctionQ40869408
The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signalingQ40891329
Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludinQ40898868
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.Q40925316
Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cellsQ40941485
Possible involvement of phosphorylation of occludin in tight junction formationQ41104367
A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptideQ41498808
Molecular architecture of tight junctionsQ41748256
Distribution of Glut1 in detergent-resistant membranes (DRMs) and non-DRM domains: effect of treatment with azideQ42439535
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsQ42796669
The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced regionQ24309039
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctionsQ24316928
Symplekin, a novel type of tight junction plaque proteinQ24317634
The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 proteinQ24324462
The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopyQ24336066
A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cellsQ24336878
Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cellsQ24515257
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteinsQ24527216
The extended protein kinase C superfamilyQ24530820
Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2Q24535830
Complex protein interactions within the human polyadenylation machinery identify a novel componentQ24554306
PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membraneQ24563377
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsQ24622878
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctionsQ24669667
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosinQ24670442
Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologuesQ24671949
Expression and polarized targeting of a rab3 isoform in epithelial cellsQ24673448
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complexQ24673684
Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin FilamentsQ24678389
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigrationQ24682572
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3Q24682973
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinQ24683294
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motifQ27634027
Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha cateninQ28137655
Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3Q28138745
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludinQ28139702
Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cellsQ28140550
Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane proteinQ28141954
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cellsQ28143877
A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactionsQ28143886
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by SnailQ28187811
Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptorQ28190701
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architectureQ28191564
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion moleculeQ28203316
Junction adhesion molecule is a receptor for reovirusQ28203704
Size-selective loosening of the blood-brain barrier in claudin-5-deficient miceQ28203769
Multifunctional strands in tight junctionsQ28210051
The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-BQ28211466
Protein kinase C regulates the phosphorylation and cellular localization of occludinQ28212556
Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alphaQ28212968
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cellsQ28214827
The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itchQ28215086
The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctionsQ28218429
Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cellsQ28273946
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epitheliaQ28299935
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeabilityQ28365900
JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1Q28506613
CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null miceQ28512612
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient miceQ28513737
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasionQ29616467
Junctional complexes in various epitheliaQ29620435
Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cellsQ30165410
The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expressionQ30175138
The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domainQ30176715
Dynamic behavior of paired claudin strands within apposing plasma membranesQ30477728
Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4.Q30882635
Isolation and purification of gap junction channelsQ33237452
Symplekin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytesQ33787860
Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB.Q33800833
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctionsQ33853393
Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29.Q33932144
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cellsQ33953411
Fracture faces of zonulae occludentes from "tight" and "leaky" epitheliaQ34051800
A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrierQ34064091
Claudins create charge-selective channels in the paracellular pathway between epithelial cellsQ34132571
Signalling to and from tight junctionsQ34180670
Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteinsQ34181110
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretionQ34507324
Occludin 1B, a variant of the tight junction protein occludinQ34684155
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cellsQ34690508
Complex phenotype of mice lacking occludin, a component of tight junction strands.Q34781594
Cell polarity: Par6, aPKC and cytoskeletal crosstalkQ35041103
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammationQ35065323
Epithelial cell adhesion and the regulation of gene expressionQ35147365
Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cellsQ36221082
Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistanceQ36221153
Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.Q36232347
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)C1213-28
P577publication date2004-06-01
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleThe tight junction: a multifunctional complex
P478volume286

Reverse relations

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Q35000704Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front
Q40383109Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
Q39505682Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells
Q35068853Downsloping high-frequency hearing loss due to inner ear tricellular tight junction disruption by a novel ILDR1 mutation in the Ig-like domain
Q33748517Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.
Q27023960Ductal barriers in mammary epithelium
Q28585735E-cadherin is required for intestinal morphogenesis in the mouse
Q37031749EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype
Q41904224EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium
Q64231849Early Porcine Sapovirus Infection Disrupts Tight Junctions and Uses Occludin as a Coreceptor
Q33792946Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution
Q35979795Effect of the synthetic NC-1059 peptide on diffusion of riboflavin across an intact corneal epithelium.
Q54245376Effects of Lactobacillus acidophilus on the growth performance and intestinal health of broilers challenged with Clostridium perfringens.
Q90452153Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats
Q61808743Effects of menthol-flavored substances at the cellular level on oral mucosal sites
Q33879992Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization
Q52608238Effects of simulated weightlessness on tight junction protein occludin and Zonula Occluden-1 expression levels in the intestinal mucosa of rats.
Q89287303Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens
Q34997041Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells
Q34113582Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients
Q37427968Emerging roles of Semaphorins in the regulation of epithelial and endothelial junctions
Q37175096Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome
Q37125689Endothelial signaling in paracellular and transcellular leukocyte transmigration
Q30734754Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis
Q39658552Enteroaggregative Escherichia coli Disrupts Epithelial Cell Tight Junctions
Q42988754Enteropathogenic Escherichia coli type III effectors EspG and EspG2 alter epithelial paracellular permeability
Q39356689Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines
Q37808213Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids
Q40352387Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8.
Q34663672Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation
Q39991114Epithelial barrier modulation by a channel forming peptide
Q37866083Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment
Q37241585Epithelial junctions and polarity: complexes and kinases
Q34752092Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis
Q37035966Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins
Q42406563EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability.
Q36326189Establishment and evaluation of an experimental rat model for high-altitude intestinal barrier injury
Q57112408Evaluation of Probiotic Properties and Safety of Isolated From Artisanal Tunisian Meat "Dried Ossban"
Q42271585Exacerbation of DSS-induced colitis in mice lacking kinin B(1) receptors through compensatory up-regulation of kinin B(2) receptors: the role of tight junctions and intestinal homeostasis
Q35578478Examination of the restoration of epithelial barrier function following superficial keratectomy.
Q54692519Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
Q54701927Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.
Q47846345Expression of claudin-11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ.
Q42464910Expression of claudin-4 and -7 in porcine gingival junctional epithelium
Q36095370Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues
Q34745325Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro
Q34742874Expression patterns of tight junction components induced by CD24 in an oral epithelial cell-culture model correlated to affected periodontal tissues
Q42037705Extracellular matrix influences alveolar epithelial claudin expression and barrier function
Q52730962Ezrin as a complementary marker in ocular toxicity assessment using a three-dimensional reconstructed human corneal-like epithelium model, EpiOcular™.
Q34971246FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes
Q37058180Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions.
Q27487550Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production
Q35109357Fibroblast growth factor-peptide improves barrier function and proliferation in human keratinocytes after radiation
Q64902988Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage-Animal, Experimental Study.
Q37225152Flavonoids from Orostachys japonicus A. Berger inhibit the invasion of LnCaP prostate carcinoma cells by inactivating Akt and modulating tight junctions
Q40054817Formation of aberrant TJ strands by overexpression of claudin-15 in MDCK II cells
Q39880913Freeze-fracture electron microscopic study of tight junction strands in HEK293 cells and MDCK II cells expressing claudin-1 mutants in the second extracellular loop
Q38911743Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.
Q35547719Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery
Q35805066Gastrointestinal Tract Commensal Bacteria and Probiotics: Influence on End-Organ Physiology
Q35154231Genetic analysis of genes related to tight junction function in the Korean population with non-syndromic hearing loss
Q30540948Germ cell migration across Sertoli cell tight junctions
Q24642680Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
Q36311041Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy
Q38223273Glutamine and intestinal barrier function
Q41665259Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets
Q40035379Glutathione-S-transferase protects against oxidative injury of endothelial cell tight junctions
Q38782324Glycine Regulates Expression and Distribution of Claudin-7 and ZO-3 Proteins in Intestinal Porcine Epithelial Cells
Q37843684Good fences make good neighbors: Gastrointestinal mucosal structure
Q36517183Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.
Q40600045Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
Q90468267Guanylate binding protein-1-mediated epithelial barrier in human salivary gland duct epithelium
Q36811569H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR.
Q39417456HIV-1 Tat triggers nuclear localization of ZO-1 via Rho signaling and cAMP response element-binding protein activation
Q47802370HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis
Q37890903Health of farmed fish: its relation to fish welfare and its utility as welfare indicator.
Q34533642Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota
Q34194569Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability
Q84434171Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1
Q34694228Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
Q39297334Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions
Q38791937High glucose induces dysfunction of airway epithelial barrier through down-regulation of connexin 43.
Q38945111Human retinal pigment epithelium cells as functional models for the RPE in vivo.
Q36949030Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cells
Q55360126Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2α mediated changes in the expression of occludin and ZO-1.
Q46886564IFN-alpha induces barrier destabilization and apoptosis in renal proximal tubular epithelium
Q37217121IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway
Q30413622ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42.
Q42814410Identification and characterization of JRAB/MICAL-L2, a junctional Rab13-binding protein
Q42513671Identification and subcellular localization of paracellin-1 (claudin-16) in human salivary glands
Q24293163Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family
Q28114962Identification of ZASP, a novel protein associated to Zona occludens-2
Q33557833Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin
Q92618333Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma
Q92208628Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma
Q35799174Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model.
Q42042176Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK.
Q40234173Impact of gluten consumption in patients with functional dyspepsia: a case-control study
Q42738693Impact of lentiviral vector-mediated transduction on the tightness of a polarized model of airway epithelium and effect of cationic polymer polyethylenimine
Q33326016Impaired barrier function by dietary fructo-oligosaccharides (FOS) in rats is accompanied by increased colonic mitochondrial gene expression
Q64982692Implications of AMPK in the Formation of Epithelial Tight Junctions.
Q47995162In ovo feeding of l-arginine regulates intestinal barrier functions of posthatch broilers by activating the mTOR signaling pathway.
Q26829514In vitro and in vivo models for the study of oral delivery of nanoparticles
Q36909324In vitro models for processes involved in intestinal absorption
Q38853152In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome
Q47927827Indocyanine green concentrations used in chromovitrectomy cause a reversible functional alteration in the outer blood-retinal barrier.
Q39433226Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells.
Q38295076Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression
Q92934682Inflammation and Endotyping in Chronic Rhinosinusitis-A Paradigm Shift
Q44800688Inflammatory mediators weaken the amniotic membrane barrier through disruption of tight junctions
Q37291210Inhibiting invasion into human bladder carcinoma 5637 cells with diallyl trisulfide by inhibiting matrix metalloproteinase activities and tightening tight junctions
Q39006131Inhibition of JNK in HaCaT cells induced tight junction formation with decreased expression of cytokeratin 5, cytokeratin 17 and desmoglein 3.
Q39824870Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression
Q39379865Inhibition of matrix metalloproteinase activities and tightening of tight junctions by diallyl disulfide in AGS human gastric carcinoma cells
Q39506558Inhibition of protein kinase C attenuates Pseudomonas aeruginosa elastase-induced epithelial barrier disruption
Q52646632Insulin protects against damage to pulmonary endothelial tight junctions after thermal injury: relationship with zonula occludens-1, F-actin, and AKT activity.
Q46184003Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland
Q35646965Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex
Q53153713Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.
Q39217461Interplay between tight junctions & adherens junctions.
Q35942675Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier
Q41036794Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications
Q92356819Intestinal barrier dysfunction in severe burn injury
Q28250081Intestinal barrier function: molecular regulation and disease pathogenesis
Q36285527Intestinal fluid absorption in anadromous salmonids: importance of tight junctions and aquaporins
Q38481730Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection
Q90205918Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation
Q42732184Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice
Q46240085Invasion of enteropathogenic Escherichia coli into host cells through epithelial tight junctions
Q39562918Involvement of HIF-1α in MLCK-dependent endothelial barrier dysfunction in hypoxia
Q24309562Involvement of actinin-4 in the recruitment of JRAB/MICAL-L2 to cell-cell junctions and the formation of functional tight junctions
Q36523471Involvement of cell junctions in hepatocyte culture functionality
Q46784809Irsogladine maleate counters the interleukin-1 beta-induced suppression in gap-junctional intercellular communication but does not affect the interleukin-1 beta-induced zonula occludens protein-1 levels in human gingival epithelial cells.
Q41503343Irsogladine maleate regulates gap junctional intercellular communication-dependent epithelial barrier in human nasal epithelial cells
Q34421669JNK is a novel regulator of intercellular adhesion
Q24306920JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin
Q40299061Japanese encephalitis virus disrupts blood-brain barrier and modulates apoptosis proteins in THBMEC cells
Q37042534Japanese encephalitis virus disrupts cell-cell junctions and affects the epithelial permeability barrier functions
Q36854925JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function
Q40108852Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells
Q34426070Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells
Q24301628Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease
Q45249905Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.
Q39904783Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells
Q38838095L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells
Q42172913Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD.
Q26745659Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome
Q33562329Lactobacillus plantarum inhibits intestinal epithelial barrier dysfunction induced by unconjugated bilirubin
Q40460208Lanthanum effect on the dynamics of tight junction opening and closing.
Q54592882Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4.
Q39500680Lipid raft-dependent adhesion of Giardia intestinalis trophozoites to a cultured human enterocyte-like Caco-2/TC7 cell monolayer leads to cytoskeleton-dependent functional injuries
Q34692863Lipopolysaccharide disrupts the milk-blood barrier by modulating claudins in mammary alveolar tight junctions
Q36572670Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins
Q35420561Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4
Q28576532Loss of claudin-1 in lipopolysaccharide-treated periodontal epithelium
Q28588532Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice
Q35924189Low claudin-6 expression correlates with poor prognosis in patients with non-small cell lung cancer
Q37565430MT2-MMP induces proteolysis and leads to EMT in carcinomas
Q36111266Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium
Q30475585Manipulating CD4+ T cells by optical tweezers for the initiation of cell-cell transfer of HIV-1.
Q40396180Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins
Q39120017Mathematical classification of tight junction protein images
Q35097182Matriptase deletion initiates a Sjögren's syndrome-like disease in mice
Q34198280Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
Q28235057Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
Q37665595Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.
Q38126941Mechanisms of absorption and elimination of drugs administered by inhalation
Q33804105Mechanisms of the epithelial-mesenchymal transition by TGF-beta
Q42513194Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receptor-dependent pathway in rats in vivo
Q44900972Melatonin inhibits alcohol-induced increases in duodenal mucosal permeability in rats in vivo
Q30914511Melatonin receptor expression in Xenopus laevis surface corneal epithelium: diurnal rhythm of lateral membrane localization.
Q92733028Metformin as Potential Therapy for High-Grade Glioma
Q33676881Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse
Q57374799Methyl-β-Cyclodextrin Increases Permeability of Caco-2 Cell Monolayers by Displacing Specific Claudins from Cholesterol Rich Domains Associated with Tight Junctions
Q34477522MicroRNA-495 induces breast cancer cell migration by targeting JAM-A.
Q35119983MicroRNA-dependent regulation of transcription in non-small cell lung cancer
Q38814829Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides
Q34422518Minireview: Steroid/nuclear receptor-regulated dynamics of occluding and anchoring junctions
Q48252141Modelling the structure of a ceRNA-theoretical, bipartite microRNA-mRNA interaction network regulating intestinal epithelial cellular pathways using R programming
Q48253457Molecular and Physiological Effects on the Small Intestine of Weaner Pigs Following Feeding with Deoxynivalenol-Contaminated Feed
Q35919870Molecular and cellular mechanisms of tight junction dysfunction in the irritable bowel syndrome
Q42436993Molecular composition of tight and adherens junctions in the rat olfactory epithelium and fila
Q36032680Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss
Q35579440Monosodium L-glutamate and dietary fat exert opposite effects on the proximal and distal intestinal health in growing pigs
Q28078199Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy
Q52647636Mycophenolic acid mediated disruption of the intestinal epithelial tight junctions.
Q36676237Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells
Q30513859Myosin-X functions in polarized epithelial cells
Q27004163Myosins in cell junctions
Q39281815NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.
Q81630691Na+/K+ -ATPase regulates tight junction formation and function during mouse preimplantation development
Q40234364Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells
Q46242347Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight junction protein degradation
Q36235912Necrotizing enterocolitis in a mouse model leads to widespread renal inflammation, acute kidney injury, and disruption of renal tight junction proteins
Q59806591Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
Q33670796Neuron-glial interactions in blood-brain barrier formation.
Q37791921New aspects of the molecular constituents of tissue barriers
Q49733749New insights into the mechanisms of pulmonary edema in acute lung injury
Q41835158Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability
Q37273510Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis
Q37044600Noncanonical TGF-β signaling during mammary tumorigenesis
Q48933269Noncoding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn's Disease
Q40287112Novel effects of azithromycin on tight junction proteins in human airway epithelia
Q46278001Novel role of zonula occludens-1: A tight junction protein closely associated with the odontoblast differentiation of human dental pulp cells
Q33916905Novel strategies to enforce an epithelial phenotype in mesenchymal cells
Q33812424Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner
Q41117734Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer
Q52648199Occludin induces microvillus formation via phosphorylation of ezrin in a mouse hepatic cell line.
Q34580003Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis
Q37580203Occludin is overexpressed in Alzheimer's disease and vascular dementia
Q34043395Occludin is required for cytokine-induced regulation of tight junction barriers
Q38936936Olive oil bioactive compounds increase body weight, and improve gut health and integrity in gilthead sea bream (Sparus aurata).
Q40145744Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions
Q37898569Osmoregulation and epithelial water transport: lessons from the intestine of marine teleost fish
Q93186070Osmoregulation in Barnacles: An Evolutionary Perspective of Potential Mechanisms and Future Research Directions
Q35582711Overexpression of Claudin-1 is Associated with Advanced Clinical Stage and Invasive Pathologic Characteristics of Oral Squamous Cell Carcinoma
Q51125382Overexpression of junctional adhesion molecule-A and EphB2 predicts poor survival in lung adenocarcinoma patients.
Q38836349Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin
Q94474115PETER-assay: Combined Impedimetric Detection of Permeability (PE) and Resistance (TER) of Barrier-Forming Cell Layers
Q34863027PPARgamma-regulated tight junction development during human urothelial cytodifferentiation
Q37327571Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules
Q26741215Pancreatic cancer stem cell markers and exosomes - the incentive push
Q40216411Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
Q37571326Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension
Q24643377Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
Q33329537Parallels between pathogens and gluten peptides in celiac sprue
Q38749105Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts
Q26852773Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers
Q47590591Peptides and Drug Delivery
Q35575592Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier.
Q58698072Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components
Q35753059Perorally active nanomicellar formulation of quercetin in the treatment of lung cancer
Q24318390Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells
Q43210831Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions
Q24302552Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells
Q36082365Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells
Q93065706Physiological Effects of Dietary Amino Acids on Gut Health and Functions of Swine
Q28270069Physiology and function of the tight junction
Q40305235Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal
Q42864321Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells
Q37162399Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function
Q89924353Porcine circovirus type 2 exploits JNK-mediated disruption of tight junctions to facilitate Streptococcus suis translocation across the tracheal epithelium
Q37167611Pores in the epidermis: aquaporins and tight junctions
Q38218137Potential contribution of type I alveolar epithelial cells to chronic neonatal lung disease
Q23919977Potential in vitro model for testing the effect of exposure to nanoparticles on the lung alveolar epithelial barrier
Q91936784Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens
Q92328671Preventive Effects of Pyungwi-san against Dextran Sulfate Sodium- and Clostridium difficile-Induced Inflammatory Bowel Disease in Mice
Q47584454Process of tight junction recovery in the injured vocal fold epithelium: Morphological and paracellular permeability analysis.
Q39753169Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity
Q36815936Progress in absorption enhancers based on tight junction
Q25257006Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling
Q38021496Proof of concept for claudin-targeted drug development
Q35168052Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions
Q28505004Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor
Q36110095Protective Effects of Bifidobacterium on Intestinal Barrier Function in LPS-Induced Enterocyte Barrier Injury of Caco-2 Monolayers and in a Rat NEC Model
Q42499191Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide
Q35220875Protective effects of carbon monoxide-releasing molecule-2 on the barrier function of intestinal epithelial cells
Q35538397Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity
Q39069181Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability
Q39429708Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Q43109201Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules
Q41982297Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells
Q41166000Pseudomonas fluorescens alters epithelial permeability and translocates across Caco-2/TC7 intestinal cells
Q37095009Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol
Q26865861Pulmonary epithelial barrier function: some new players and mechanisms
Q23909818Pulmonary toxicity and fibrogenic response of carbon nanotubes
Q49308998RETRACTED: Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa
Q30439491RNA interference techniques to study epithelial cell adhesion and polarity
Q39647501Rab5a-mediated localization of claudin-1 is regulated by proteasomes in endothelial cells
Q40084486Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
Q34713252Recombinant Treponema pallidum protein Tp0965 activates endothelial cells and increases the permeability of endothelial cell monolayer
Q38978743Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals
Q37423257Regulation and roles for claudin-family tight junction proteins
Q91994983Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor
Q24548016Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA
Q55020558Regulation of defensive function on gingival epithelial cells can prevent periodontal disease.
Q38989676Regulation of epithelial cell tight junctions by protease-activated receptor 2.
Q52597922Regulation of intestinal epithelial barrier function by lncRNA uc.173 through interaction with miR-29b.
Q37903873Regulation of small GTPases at epithelial cell-cell junctions
Q28534173Regulation of the Epithelial-Mesenchymal Transition by Claudin-3 and Claudin-4
Q33306608Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2
Q46897794Regulation of tight junction proteins occludin and claudin 5 in the primate ovary during the ovulatory cycle and after inhibition of vascular endothelial growth factor
Q39336324Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells
Q38091094Regulation of tight junctions in upper airway epithelium
Q37438622Remodeling of the tight junction during recovery from exposure to hydrogen peroxide in kidney epithelial cells
Q35544541Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct
Q33589127Renal salt wasting and chronic dehydration in claudin-7-deficient mice
Q40120136Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function
Q34253519Review article: coeliac disease, new approaches to therapy.
Q41037462Rhinovirus disrupts the barrier function of polarized airway epithelial cells
Q37687727Rho signaling and tight junction functions
Q92155709Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy
Q39604565Role of MnSOD in propofol protection of human umbilical vein endothelial cells injured by heat stress.
Q43358546Role of TNF-alpha in ileum tight junction alteration in mouse model of restraint stress
Q34888133Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens
Q47102832Role of matrix metalloproteinase-2/9 (MMP2/9) in lead-induced changes in an in vitro blood-brain barrier model
Q36944609Role of mitochondrial respiratory chain complex III in high glucose peritoneal dialysate-induced hyperpermeability of HPMCs
Q43369504Role of peroxisome proliferator-activated receptor-alpha in ileum tight junction alteration in mouse model of restraint stress
Q38594976Role of tight junctions in signal transduction: an update.
Q36034293Roles for claudins in alveolar epithelial barrier function.
Q46766045Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption
Q37127816Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters
Q53369999Sequential keratinocytic differentiation and maturation in a three-dimensional model of human artificial oral mucosa.
Q28507821Serum response factor is essential for the proper development of skin epithelium
Q87903755Severe Intestinal Inflammation in the Small Intestine of Mice Induced by Controllable Deletion of Claudin-7
Q35683125Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells
Q36083770Signaling the junctions in gut epithelium
Q37305578Signaling to the apical membrane and to the paracellular pathway: changes in the cytosolic proteome of Aedes Malpighian tubules
Q38745016Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome.
Q58701856Staphylococcus aureus colonization and non-influenza respiratory viruses: Interactions and synergism mechanisms
Q33749178Streptolysin S Contributes to Group A Streptococcal Translocation across an Epithelial Barrier
Q38510131Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability
Q36417189Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant
Q37587896Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating
Q38110756Structure and function of the thin limbs of the loop of Henle
Q34746651Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis-like intestinal injury
Q28271194Systems Proteomics View of the Endogenous Human Claudin Protein Family
Q36167575TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury
Q38026601Targeting claudin-4 in human pancreatic cancer
Q38242808Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
Q34544987Telocytes in pleura: two- and three-dimensional imaging by transmission electron microscopy
Q37019181The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis
Q34007920The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control.
Q28088573The Mammalian Blood-Testis Barrier: Its Biology and Regulation
Q39794504The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain
Q34313436The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis.
Q46220466The antimicrobial protein S100A7/psoriasin enhances the expression of keratinocyte differentiation markers and strengthens the skin's tight junction barrier
Q41971348The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector
Q38899745The blood-brain barrier in Alzheimer's disease.
Q47744737The brain-gut axis of fish: Rainbow trout with low and high cortisol response show innate differences in intestinal integrity and brain gene expression
Q39044859The choroid plexus as a sex hormone target: Functional implications
Q37302556The claudin family of proteins in human malignancy: a clinical perspective
Q47606483The effect of fluoride on the structure, function, and proteome of intestinal epithelia.
Q51423431The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells.
Q23921939The effects of carbon nanotubes on lung and dermal cellular behaviors
Q35145246The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues
Q34647328The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota
Q41913798The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction
Q98178641The impact of exogenous dietary nucleotides in ameliorating Clostridium perfringens infection and improving intestinal barriers gene expression in broiler chicken
Q38866280The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities
Q28277155The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins
Q89763104The multifarious regulation of the apical junctional complex
Q30439653The primary defect in experimental ileitis originates from a nonhematopoietic source
Q35128247The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model.
Q38021497The protein C pathway in intestinal barrier function: challenging the hemostasis paradigm
Q82263885The role of EFA6, exchange factor for Arf6, for tight junction assembly, functions, and interaction with the actin cytoskeleton
Q38004034The role of glia in retinal vascular disease
Q37327736The role of histamine in opening blood-tumor barrier
Q28289667The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease
Q36499221The status of intercellular junctions in established lens epithelial cell lines.
Q35763162The suprabasal layer of corneal epithelial cells represents the major barrier site to the passive movement of small molecules and trafficking leukocytes
Q30159513The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties
Q54446299Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.
Q37038324Tight junction composition is altered in the epithelium of polycystic kidneys
Q36343793Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases
Q46522622Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
Q46285157Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells
Q38077200Tight junction-related human diseases
Q52889385Tight junctions and differentiation--a chicken or the egg question?
Q41851522Tight junctions and enteropathogenic E. coli
Q37139446Tight junctions and the modulation of barrier function in disease
Q51973279Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos.
Q46779417Tight junctions in Gerbil von Ebner's gland: horseradish peroxidase and freeze-fracture studies
Q28592632Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice
Q27012318Tight junctions in human pancreatic duct epithelial cells
Q36950607Tight junctions on the move: molecular mechanisms for epithelial barrier regulation
Q42553611Tight junctions, but not too tight: fine control of lung permeability by claudins
Q27697986Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
Q37420725Tight junctions: a barrier to the initiation and progression of breast cancer?
Q36400271Tight junctions: molecular architecture and function
Q33817720Tissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective
Q35071781Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation
Q37800529Toward managing chronic rejection after lung transplant: The fate and effects of inhaled cyclosporine in a complex environment
Q48288788Toxicity of antimony, copper, cobalt, manganese, titanium and zinc oxide nanoparticles for the alveolar and intestinal epithelial barrier cells in vitro.
Q30529634Transcription factor AP-2γ is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis.
Q40046453Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells
Q34033442Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells
Q39580311Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells
Q28261649Transcriptional regulators of claudins in epithelial tight junctions
Q30486105Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia
Q57491188Transepithelial transport across the blood–testis barrier
Q42135913Transport of Aflatoxin M(1) in Human Intestinal Caco-2/TC7 Cells.
Q33589265Transporters beyond transport. Focus on "Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels"
Q41674652Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis
Q26747766Tricellular Tight Junctions in the Inner Ear
Q24679401Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
Q28511757Tricellulin deficiency affects tight junction architecture and cochlear hair cells.
Q30491701Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability
Q28505155Tricellulin is expressed in autotypic tight junctions of peripheral myelinating Schwann cells
Q39607481Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses.
Q34602194Uremia and chronic kidney disease: the role of the gut microflora and therapies with pro- and prebiotics
Q38130285Uriniferous tubule: structural and functional organization
Q89063384VCAM-1 induces signals that stimulate ZO-1 serine phosphorylation and reduces ZO-1 localization at lung endothelial cell junctions
Q40072183VEGF modulation of retinal pigment epithelium resistance
Q85574642Value of PAX8, PAX2, claudin-4, and h-caldesmon immunostaining in distinguishing peritoneal epithelioid mesotheliomas from serous carcinomas
Q37534948Vascular dysfunction in the diabetic placenta: causes and consequences.
Q48925865Vascular endothelium and the blood-brain barrier
Q49411040Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells
Q36520330Vitamin D/VDR signaling attenuates lipopolysaccharide‑induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier
Q36619404White matter rafting--membrane microdomains in myelin
Q57118452Xylanase supplementation to a wheat-based diet alleviated the intestinal mucosal barrier impairment of broiler chickens challenged by Clostridium perfringens
Q90641015ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells
Q30157199ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
Q37524262Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
Q83275613Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers
Q37239701[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- κ B/Snail Signal Transduction Pathway
Q55440555[Bioinformatic screening of key genes controlling the development and progression of lung cancer].
Q54391705[Cytoprotective and antiangiogenic effects of the multikinase inhibitor sorafenib on human retinal pigmentepithelium].
Q55449139[Expression and significance of Snail and Claudin-3 in non-small cell lung cancer].
Q39695461c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells
Q36336583c-Yes response to growth factor activation
Q40101277cAMP-dependent activation of protein kinase A attenuates respiratory syncytial virus-induced human airway epithelial barrier disruption.
Q24306134hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells
Q38958450miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.
Q39125547p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes

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