Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

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Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.148.4.791
P932PMC publication ID2169369
P698PubMed publication ID10684259
P5875ResearchGate publication ID12631759

P2093author name stringD Li
R J Mrsny
P2860cites workRho protein regulates tight junctions and perijunctional actin organization in polarized epitheliaQ24563849
Occludin: a novel integral membrane protein localizing at tight junctionsQ24657666
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctionsQ24672971
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
Mammalian occludin in epithelial cells: its expression and subcellular distributionQ28245297
Genetic alterations during colorectal-tumor developmentQ28281200
The complexity of Raf-1 regulationQ28305850
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryosQ29041617
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinaseQ30450248
E-cadherin downregulation in cancer: fuel on the fire?Q33594178
Transmembrane proteins in the tight junction barrier.Q33653833
Occludin and claudins in tight-junction strands: leading or supporting players?Q33659718
Modulation of tight junction structure in blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytesQ34059665
A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrierQ34064091
Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculinQ36255361
Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPasesQ36256190
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctionsQ36289162
Connexin-occludin chimeras containing the ZO-binding domain of occludin localize at MDCK tight junctions and NRK cell contactsQ36293286
Multilayering and loss of apical polarity in MDCK cells transformed with viral K-rasQ36529343
Occludin is a functional component of the tight junction.Q36828867
Cellular junctions in a spectrum of human malignant tumorsQ39523592
Chemical carcinogenesis: from animal models to molecular models in one decadeQ39643987
The mitogen-activated protein kinases, ERK1 and ERK2.Q40558045
Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cellsQ40734122
Cadherins in cancer: implications for invasion and metastasisQ40780329
A dominant mutant of occludin disrupts tight junction structure and functionQ40952254
Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealingQ40962620
Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletionQ41010393
Role of gap junctions in lung neoplasiaQ41026611
Phosphorylation of occludin correlates with occludin localization and function at the tight junctionQ41070997
Oncogenic raf-1 induces the expression of non-histone chromosomal architectural protein HMGI-C via a p44/p42 mitogen-activated protein kinase-dependent pathway in salivary epithelial cellsQ41089150
Ras effectorsQ41099716
Effects of Epidermal Growth Factor versus Phorbol Ester on Kidney Epithelial (LLC-PK1) Tight Junction Permeability and Cell DivisionQ41540294
Regulation of the movement of solutes across tight junctionsQ41748263
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsQ42796669
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinaseQ42820729
Direct staining and visualization of endothelial monolayers cultured on synthetic polycarbonate filtersQ43841478
Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins.Q48010453
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutationsQ48396942
Disruption of circumferential actin filament causes disappearance of occludin from the cell borders of rat hepatocytes in primary culture without distinct changes of tight junction strands.Q52535251
Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-alpha.Q53437872
E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma.Q55068058
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)791-800
P577publication date2000-02-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleOncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin
P478volume148

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cites work (P2860)
Q35992219A novel Peptide to treat oral mucositis blocks endothelial and epithelial cell apoptosis
Q40156970A novel monoclonal antibody against the second extracellular loop of occludin disrupts epithelial cell polarity
Q39980778A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion
Q33286983A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells
Q39625147A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions
Q44737204Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression
Q40561982Annexin A2 heterotetramer: role in tight junction assembly
Q33584151Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells
Q33509293Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.
Q91723199Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
Q59351142Cellular and Molecular Events in the Airway Epithelium Defining the Interaction Between House Dust Mite Group 1 Allergens and Innate Defences
Q36482218Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: regulatory role of heat shock factor-1.
Q39527898Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer
Q42488651Claudins regulate the intestinal barrier in response to immune mediators
Q39676905Co-culture based blood-brain barrier in vitro model, a tissue engineering approach using immortalized cell lines for drug transport study
Q39270897Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells
Q34781594Complex phenotype of mice lacking occludin, a component of tight junction strands.
Q35627444Contrasting effects of ERK on tight junction integrity in differentiated and under-differentiated Caco-2 cell monolayers
Q40715731Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program
Q38825519Current trends in salivary gland tight junctions.
Q39348423Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway
Q45717757Detection of claudin-4 in salivary gland neoplasms (a study utilizing RT-PCR and immunohistochemistry).
Q54682146Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas.
Q35849118Endosomal regulation of contact inhibition through the AMOT:YAP pathway.
Q52580604Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells.
Q36827092Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice
Q39438592Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer.
Q34783580Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins
Q40030315Expression of junctional proteins in choroid plexus epithelial cell lines: a comparative study
Q35150365Functional analysis of tight junctions
Q40490783HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion
Q46437339HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation
Q42814410Identification and characterization of JRAB/MICAL-L2, a junctional Rab13-binding protein
Q24293163Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family
Q101403199In vitro protective effects of Paeonia mascula subsp. hellenica callus extract on human keratinocytes
Q39540274Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway
Q95841490Intestinal Barrier Integrity in Heat-Stressed Modern Broilers and Their Ancestor Wild Jungle Fowl
Q45249905Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.
Q37259782LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.
Q44176141Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection
Q41964987MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide
Q34517760MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer
Q38685179MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients
Q24338226MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival
Q37047074MicroRNA regulation of intestinal epithelial tight junction permeability
Q46531979Modulation of extracellular conditions prevents the multilayering of the simple epithelium.
Q37982360Modulation of tight junction structure and function by kinases and phosphatases targeting occludin
Q38974315Molecular Mechanism for Various Pharmacological Activities of NSAIDS
Q37058221Molecular analysis of neural crest migration
Q28210051Multifunctional strands in tight junctions
Q24515257Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells
Q24680419OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes
Q37341757Occludin expression in brain tumors and its relevance to peritumoral edema and survival
Q36217272Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1)
Q34718156Organogenesis: molecular mechanisms of tubulogenesis
Q33952894Ouabain modulates epithelial cell tight junction.
Q46570774Oxidative stress-induced disruption of epithelial and endothelial tight junctions.
Q40216411Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
Q33757305Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription
Q37591643Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis
Q45251310Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells
Q37162399Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function
Q25257006Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma modulate epithelial barrier function in Madin-Darby canine kidney cells through mitogen activated protein kinase signaling
Q39737951Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels
Q42500061Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium.
Q80149165Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug
Q40444996Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells
Q39847326Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes.
Q91994983Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor
Q24548016Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA
Q33863571Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.
Q38021500Regulation of epithelial proliferation by tight junction proteins
Q59795352Replacement of grains with soybean hulls ameliorates SARA-induced impairment of the colonic epithelium barrier function of goats
Q37409822Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells
Q40607486Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis
Q40788021Selective control of basolateral membrane protein polarity by cdc42.
Q34180670Signalling to and from tight junctions
Q36734066The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis
Q23915639The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src
Q36322940The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
Q34157263The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium
Q40869408The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
Q35875599The role of altered cell-cell communication in melanoma progression
Q40439617The second loop of occludin is required for suppression of Raf1-induced tumor growth
Q36660697The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state
Q35777543The tight junction: a multifunctional complex
Q36337194Tight junction biology and kidney dysfunction
Q37118065Tight junction proteins: from barrier to tumorigenesis.
Q34086502Tight junction, a platform for trafficking and signaling protein complexes
Q33674271Tight junctions in salivary epithelium
Q38879992Tight junctions: from simple barriers to multifunctional molecular gates
Q36400271Tight junctions: molecular architecture and function
Q47600589Transepithelial leak in Barrett's esophagus
Q51698147Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids.
Q36711812Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration
Q44364560Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes
Q34070506ZO proteins redundantly regulate the transcription factor DbpA/ZONAB
Q38734544ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture.
Q58573957Zinc Ameliorates Intestinal Barrier Dysfunctions in Shigellosis by Reinstating Claudin-2 and -4 on the Membranes
Q35401854Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands with Sjögren's syndrome
Q36336583c-Yes response to growth factor activation

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