The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota

scientific article

The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1128/CMR.19.2.315-337.2006
P932PMC publication ID1471992
P698PubMed publication ID16614252
P5875ResearchGate publication ID7166490

P2093author name stringAlain L Servin
Vanessa Liévin-Le Moal
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Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucinQ22010623
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Microflora of the gastrointestinal tract: a review.Q34322227
Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cellsQ34360382
Molecular architecture of adherens junctionsQ34360617
Lactobacillus acidophilus LA 1 binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteriaQ34378895
Human enteric defensins. Gene structure and developmental expressionQ34379039
Adhesion of human enterotoxigenic Escherichia coli to human mucus secreting HT-29 cell subpopulations in cultureQ34379824
Mucins in the gastrointestinal tract in health and diseaseQ34386379
Structural organization and classification of the human mucin genesQ34386462
Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationshipsQ34397281
Genomics at work: the global gene response to enteric bacteriaQ34400960
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cellsQ34407161
The indigenous gastrointestinal microfloraQ34409976
A molecular view of the intestinal ecosystem.Q34440247
Paneth cells and innate immunity in the crypt microenvironmentQ34444506
Molecular structure and assembly of the tight junction.Q34455527
Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunityQ34469853
The intestinal epithelial stem cellQ34488153
The multifaceted Paneth cellQ34531936
Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathwaysQ34532741
Cathelicidins--a family of multifunctional antimicrobial peptides.Q34534231
Probiotics reduce enterohemorrhagic Escherichia coli O157:H7- and enteropathogenic E. coli O127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangementsQ34559453
How the gut senses its content.Q34565124
Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunityQ34574499
How do bacteria resist human antimicrobial peptides?Q34575973
Regulation of flagellar assemblyQ34588853
The bifidobacterial and Lactobacillus microflora of humansQ34665483
Epithelial antimicrobial peptides and proteins: their role in host defence and inflammationQ34674304
How host-microbial interactions shape the nutrient environment of the mammalian intestineQ34675981
Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expressionQ34716119
Antagonistic activity exerted in vitro and in vivo by Lactobacillus casei (strain GG) against Salmonella typhimurium C5 infectionQ34737893
Interactions between the microbiota and the intestinal mucosaQ34763464
Adherens junctions: new insight into assembly, modulation and functionQ34811538
Intestinal flora during the first months of life: new perspectives.Q34820480
Antagonistic activity of Lactobacillus acidophilus LB against intracellular Salmonella enterica serovar Typhimurium infecting human enterocyte-like Caco-2/TC-7 cellsQ33986792
Antibiotic resistance in Salmonella enterica serovar Typhimurium exposed to microcin-producing Escherichia coliQ33990128
Class II antimicrobial peptides from lactic acid bacteriaQ33994632
Quorum sensing is a global regulatory mechanism in enterohemorrhagic Escherichia coli O157:H7Q33996772
Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune systemQ34000988
Protective effect of Lactobacillus casei strain Shirota on Shiga toxin-producing Escherichia coli O157:H7 infection in infant rabbitsQ34006082
Epithelia: not just physical barriersQ34017925
Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal diseaseQ34032146
Tight junction, a platform for trafficking and signaling protein complexesQ34086502
Ultrastructure of Paneth cells in the intestine of various mammalsQ34088289
A Lactobacillus acidophilus strain of human gastrointestinal microbiota origin elicits killing of enterovirulent Salmonella enterica Serovar Typhimurium by triggering lethal bacterial membrane damageQ34097875
pH-, Lactic acid-, and non-lactic acid-dependent activities of probiotic Lactobacilli against Salmonella enterica Serovar TyphimuriumQ34098013
MUC17, a novel membrane-tethered mucin.Q34115097
Paneth cell trypsin is the processing enzyme for human defensin-5.Q34129474
Molecular assessment of intestinal microfloraQ34130926
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to surviveQ34137381
Structure and function of Toll-like receptor proteinsQ34146916
Human MUC1 mucin: a multifaceted glycoprotein.Q34147898
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathwaysQ34155054
The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiotaQ34156291
Paneth cell defensins and innate immunity of the small bowelQ34171943
Signalling to and from tight junctionsQ34180670
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensinQ34186394
How Bacteria Assemble FlagellaQ34194719
NODs: intracellular proteins involved in inflammation and apoptosisQ34199862
Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37.Q34200002
Lantibiotics: structure, biosynthesis and mode of actionQ34248859
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer.Q34274121
Bacterial colonization leads to the colonic secretion of RELMβ/FIZZ2, a novel goblet cell-specific proteinQ34274465
Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis.Q34292705
Trypsin mediates growth phase-dependent transcriptional tegulation of genes involved in biosynthesis of ruminococcin A, a lantibiotic produced by a Ruminococcus gnavus strain from a human intestinal microbiotaQ34304204
MEF up-regulates human beta-defensin 2 expression in epithelial cells.Q34304777
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
Antimicrobial peptides (AMPs): peptide structure and mode of actionQ36275702
Bacterial exposure induces and activates matrilysin in mucosal epithelial cellsQ36326278
A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystemQ36436689
Quorum sensing in Escherichia coli and Salmonella typhimurium.Q36507025
Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coliQ36783792
Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ.Q36852656
Structure, function and gene expression of epithelial mucins.Q36878241
Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides.Q36899142
Invasion by Salmonella typhimurium is affected by the direction of flagellar rotationQ36946395
Salmonella typhimurium mutants lacking flagella or motility remain virulent in BALB/c miceQ36975775
Cholera enterotoxin-induced mucus secretion and increase in the mucus blanket of the rabbit ileum in vivoQ37000648
Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activityQ37368468
Large-scale population structure of human commensal Escherichia coli isolatesQ37553049
Intestinal defensin gene expression in human populations.Q38971813
Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cellsQ39318238
Antibacterial activity evaluation of microcin J25 against diarrheagenic Escherichia coliQ39488077
Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide.Q39512909
Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiologyQ39523461
Antibiotic-induced lipopolysaccharide (LPS) release from Salmonella typhi: delay between killing by ceftazidime and imipenem and release of LPS.Q39557331
Helicobacter pylori-mediated transcriptional regulation of the human beta-defensin 2 gene requires NF-kappaB.Q39567005
Listeria monocytogenes stimulates mucus exocytosis in cultured human polarized mucosecreting intestinal cells through action of listeriolysin O.Q39572243
Mucin exocytosis: a major target for Helicobacter pyloriQ39610750
Helicobacter pylori uses motility for initial colonization and to attain robust infectionQ39654398
Quorum-sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli.Q39655068
The Afa/Dr adhesins of diffusely adhering Escherichia coli stimulate interleukin-8 secretion, activate mitogen-activated protein kinases, and promote polymorphonuclear transepithelial migration in T84 polarized epithelial cellsQ39730178
PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistanceQ39843622
Microcin 15m from Escherichia coli: mechanism of antibiotic actionQ39856613
Canonical Wnt signals are essential for homeostasis of the intestinal epitheliumQ39895829
Mucin degradation mechanisms by distinct Pseudomonas aeruginosa isolates in vitro.Q39912942
Microcin 25, a novel antimicrobial peptide produced by Escherichia coliQ39939774
Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 CellsQ39955901
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.Q40017434
Binding of Yersinia enterocolitica to rabbit intestinal brush border membranes, mucus, and mucinQ40159854
Novel effects of the prototype translocating Escherichia coli, strain C25 on intestinal epithelial structure and barrier functionQ40347391
Mucin gene structure and expression: protection vs. adhesionQ40377654
The increase in mucin exocytosis and the upregulation of MUC genes encoding for membrane-bound mucins induced by the thiol-activated exotoxin listeriolysin O is a host cell defence response that inhibits the cell-entry of Listeria monocytogenesQ40410400
Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive Escherichia coli isolated from Crohn's disease patients to adhere to and to invade intestinal epithelial cellsQ40414006
Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domainQ40432691
Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escherichia coli-infected T84 cells.Q40450359
Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cellsQ41011699
Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria.Q41033205
Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAsQ41066090
Neurotensin and neuromedin N stimulate mucin output from human goblet cells (Cl.16E) via neurotensin receptorsQ41083074
Purinergic agonists, but not cAMP, stimulate coupled granule fusion and Cl- conductance in HT29-Cl.16E.Q41088569
Early functional effects of Clostridium difficile toxin A on human colonocytesQ41108206
The trefoil peptide familyQ41117683
Differential stimulation of intestinal mucin secretion by cholera toxin and carbacholQ41125651
Recent aspects of the regulation of intestinal mucus secretionQ41131954
Paneth cell defensins: endogenous peptide components of intestinal host defenseQ41135366
Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membraneQ41180211
Differentiation-associated antimicrobial functions in human colon adenocarcinoma cell linesQ41185478
Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT29-C1.16E).Q41231557
Ca2+ and cAMP activate different K+ conductances in the human intestinal goblet cell line HT29-Cl.16EQ41340947
Cyclic AMP-induced mucin exocytosis is independent of Cl- movements in human colonic epithelial cells (HT29-Cl.16E).Q41410834
Role of calcium in carbachol- and neurotensin-induced mucin exocytosis in a human colonic goblet cell line and cross-talk with the cyclic AMP pathwayQ41473745
ATP-stimulated electrolyte and mucin secretion in the human intestinal goblet cell line HT29-Cl.16E.Q41501275
Adhering heat-killed human Lactobacillus acidophilus, strain LB, inhibits the process of pathogenicity of diarrhoeagenic bacteria in cultured human intestinal cellsQ41501382
Inhibition of adhesion of enteroinvasive pathogens to human intestinal Caco-2 cells by Lactobacillus acidophilus strain LB decreases bacterial invasionQ41502745
Competitive exclusion of diarrheagenic Escherichia coli (ETEC) from human enterocyte-like Caco-2 cells by heat-killed LactobacillusQ41634513
A 450-kb contig of defensin genes on human chromosome 8p23.Q41673770
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.Q41705704
Molecular architecture of tight junctionsQ41748256
Interaction of cholera toxin with cloned human goblet cells in monolayer cultureQ41753254
Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-culturesQ42018332
Histochemistry of the surface mucous gel layer of the human colonQ42130607
Paneth cells and antibacterial host defense in neonatal small intestineQ42148628
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activityQ42158764
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.Q42161372
Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitroQ42282244
The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia proteinQ42465603
Functional VIP receptors in the human mucus-secreting colonic epithelial cell line CL.16E.Q42492689
Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensinsQ42522378
A model of host-microbial interactions in an open mammalian ecosystemQ42634168
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.Q42673580
Human beta-defensin-1: A urinary peptide present in variant molecular forms and its putative functional implicationQ42827761
Respiratory mucins: identification of core proteins and glycoformsQ42982717
H pylori colocalises with MUC5AC in the human stomachQ43086435
Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's diseaseQ43566703
Bacterial modification of LPS and resistance to antimicrobial peptidesQ43718689
Antagonistic activity of Lactobacillus casei strain shirota against gastrointestinal Listeria monocytogenes infection in ratsQ43910008
Lactobacillus plantarum 299v inhibits Escherichia coli-induced intestinal permeabilityQ43930057
beta-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidimeQ44218603
Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides.Q44254786
Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genesQ44536629
Antimicrobial peptides are among the antagonistic metabolites produced by Bifidobacterium against Helicobacter pyloriQ44596850
H. pylori decreases gastric mucin synthesis via inhibition of galactosyltransferaseQ44627335
Effects of microcin 24-producing Escherichia coli on shedding and multiple-antimicrobial resistance of Salmonella enterica serotype typhimurium in pigsQ45210691
Murine intestinal mucins inhibit rotavirus infection.Q46038651
Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens.Q46266208
Maternal adaptive immunity influences the intestinal microflora of suckling miceQ46336227
Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pyloriQ46571686
Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8.Q46809881
Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37.Q47275919
Inhibition of Salmonella enterica serovars by microcin J25.Q47304615
Transcriptional control of the antimicrobial peptide resistance ugtL gene by the Salmonella PhoP and SlyA regulatory proteinsQ47316351
Induction of protective IgA by intestinal dendritic cells carrying commensal bacteriaQ47962035
Use of bacteriocin promoters for gene expression in Lactobacillus plantarum C11.Q47973273
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistanceQ48038471
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.Q50091911
Flagella-mediated bacterial motility accelerates but is not required for Salmonella serotype Enteritidis invasion of differentiated Caco-2 cellsQ50094605
Ruminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human fecesQ31004928
Resistance to host antimicrobial peptides is necessary for Salmonella virulenceQ31030619
PhoP-regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B.Q31085117
Microcin E492 antibacterial activity: evidence for a TonB-dependent inner membrane permeabilization on Escherichia coliQ31151217
Does Helicobacter pylori affect gastric mucin expression? Relationship between gastric antral mucin expression and H. pylori colonizationQ32010545
Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte-like cellsQ32109047
Development of the human gastrointestinal tract: twenty years of progressQ33535761
Developmental microbial ecology of the neonatal gastrointestinal tractQ33610632
Influences of microbiota on intestinal immune system developmentQ33610638
Antimicrobial peptides as mediators of epithelial host defenseQ33657838
M cells as ports of entry for enteroinvasive pathogens: mechanisms of interaction, consequences for the disease processQ33669591
IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier.Q33709901
Comprehensive study of the intestinal stage of listeriosis in a rat ligated ileal loop system.Q33750545
The structure and assembly of secreted mucinsQ33763293
Defensins and innate host defence of the gastrointestinal tractQ33774141
Analyzing the molecular foundations of commensalism in the mouse intestineQ33840574
Stem cells: the intestinal stem cell as a paradigm.Q33846215
Bacterial regulation of intestinal immune responsesQ33930753
Gut instincts: thoughts on intestinal epithelial stem cellsQ33936387
Glycans as legislators of host-microbial interactions: spanning the spectrum from symbiosis to pathogenicityQ33941416
Collaboration of epithelial cells with organized mucosal lymphoid tissues.Q33955758
Structure and biology of cathelicidinsQ33970134
AnoikisQ33978500
Antimicrobial activity of intraurethrally administered probiotic Lactobacillus casei in a murine model of Escherichia coli urinary tract infectionQ33982279
Distribution of bifidobacterial species in human intestinal microflora examined with 16S rRNA-gene-targeted species-specific primersQ33985774
Commensal host-bacterial relationships in the gutQ28188763
Antimicrobial and Protease Inhibitory Functions of the Human Cathelicidin (hCAP18/LL-37) ProsequenceQ28201013
Defensins: antimicrobial peptides of innate immunityQ28204453
Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattractionQ28204611
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteriaQ28204776
Cathelicidins, multifunctional peptides of the innate immunityQ28205494
Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural proteinQ28208128
Multifunctional strands in tight junctionsQ28210051
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expressionQ28211358
Cathelicidins: a family of endogenous antimicrobial peptidesQ28213120
Anoikis mechanismsQ28215553
Mucins in cancer: protection and control of the cell surfaceQ28235006
A peptide antibiotic from human skinQ28242199
The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestryQ28247017
Antimicrobial polypeptides of the human colonic epitheliumQ28250179
MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesisQ28291183
hBD-1: a novel beta-defensin from human plasmaQ28294850
Innate immunity and the normal microfloraQ28373296
Increased diversity of intestinal antimicrobial peptides by covalent dimer formationQ28505962
Extracellular regulated kinase (ERK)-dependent regulation of sialomucin complex/rat Muc4 in mammary epithelial cellsQ28564603
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tractQ28587612
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4Q28592260
Wnt signalling induces maturation of Paneth cells in intestinal cryptsQ28593773
Defensins: endogenous antibiotic peptides from human leukocytesQ28612115
Molecular analysis of commensal host-microbial relationships in the intestineQ29614776
Toll-like receptors and innate immunityQ29615458
Interactions between commensal intestinal bacteria and the immune systemQ29617039
Linking colorectal cancer to Wnt signalingQ29619810
The MUC family: an obituary.Q30329963
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cellsQ30476839
The Lactobacillus and Bifidobacterium microflora of the human intestine: composition and successionQ30666032
Focus on modified microcins: structural features and mechanisms of actionQ30869207
Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activityQ30873433
Germ-free and colonized mice generate the same products from enteric prodefensinsQ30931828
In vitro adherence properties of Lactobacillus rhamnosus DR20 and Bifidobacterium lactis DR10 strains and their antagonistic activity against an enterotoxigenic Escherichia coliQ31004513
Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxinsQ35737867
Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune systemQ35742370
Defensin-mediated innate immunity in the small intestineQ35762898
The tight junction: a multifunctional complexQ35777543
Towards an understanding of the role of NOD2/CARD15 in the pathogenesis of Crohn's diseaseQ35781073
Signalling mechanisms of anoikisQ35787408
The role of Paneth cells and their antimicrobial peptides in innate host defense.Q35847082
Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesisQ35890674
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogensQ35890738
The role of Toll-like receptors and Nod proteins in bacterial infectionQ35914426
Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactionsQ35962003
Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung diseaseQ35967062
Adherence of diarrheagenic Escherichia coli strains to epithelial cells.Q35993185
Membrane interactions of host-defense peptides studied in model systems.Q36002916
Who's talking to whom? Epithelial-bacterial pathogen interactions.Q36015003
Defensins and mucosal protection.Q36019624
Compartmentalization of the mucosal immune responses to commensal intestinal bacteriaQ36024753
Cell and molecular biology of the small intestine: new insights into differentiation, growth and repair.Q36036420
The Paneth cell and the innate immune responseQ36036656
Recent findings in the cell and molecular biology of the small intestineQ36041921
Defence molecules in intestinal innate immunity against bacterial infectionsQ36041934
Wnt, stem cells and cancer in the intestineQ36044404
Organization of vesicular trafficking in epitheliaQ36058478
Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis.Q36077370
Human defensinsQ36094398
Intestinal microbiotaQ36095198
Bacterial modulation of mucosal innate immunityQ36097463
Innate immune defence in the human gastrointestinal tract.Q36097469
Immune responses that adapt the intestinal mucosa to commensal intestinal bacteriaQ36122642
Defensins and other antimicrobial peptides: a historical perspective and an updateQ36126577
Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibioticsQ36126588
Commensal gut bacteria: mechanisms of immune modulationQ36143433
Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathwaysQ36253626
Microbial ecology of the gastrointestinal tractQ22255628
Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibioticQ24290539
Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cellsQ24291012
Angiogenins: a new class of microbicidal proteins involved in innate immunityQ24293270
Antimicrobial peptides in the first line defence of human colon mucosaQ24308002
Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia proteinQ24310252
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsQ24314491
Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretionQ24322937
Intracellular vs extracellular recognition of pathogens--common concepts in mammals and fliesQ24498417
Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat arrayQ24530913
Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epitheliumQ24537181
Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917Q24561803
Defensins. Natural peptide antibiotics of human neutrophilsQ24563852
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lungQ24564556
Toll-like receptor signallingQ24570126
Mucins and inflammatory bowel diseaseQ24669634
Escherichia coli strains colonising the gastrointestinal tract protect germfree mice against Salmonella typhimurium infectionQ24669669
Localization of human intestinal defensin 5 in Paneth cell granulesQ24674859
Antimicrobial substance from a human Lactobacillus strainQ24676914
Toll-like receptor downstream signalingQ24799256
Innate immune recognitionQ27860721
Notch signaling: cell fate control and signal integration in developmentQ27861061
Human beta-defensin-2Q28139532
Epithelial M cells: differentiation and functionQ28141133
Antimicrobial peptides of lactic acid bacteria: mode of action, genetics and biosynthesisQ28141541
Abundant human beta-defensin-1 expression in milk and mammary gland epitheliumQ28142157
Toll-like receptors in the induction of the innate immune responseQ28144797
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defenseQ28145389
Intestinal microflora in early infancy: composition and developmentQ28181875
Mucin and Toll-like receptors in host defense against intestinal parasitesQ28186441
Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells.Q40500121
In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strainQ40526966
Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activationQ40532416
Signal transduction, packaging and secretion of mucinsQ40543271
Epithelial mucin genesQ40543275
Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transportQ40557124
The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogensQ40574865
Induction of plantaricin production in Lactobacillus plantarum NC8 after coculture with specific gram-positive bacteria is mediated by an autoinduction mechanismQ40584967
Membrane ruffling and invasion of human and avian cell lines is reduced for aflagellate mutants of Salmonella enterica serotype EnteritidisQ40632610
LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cellsQ40648497
CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cellsQ40659073
Human serum amyloid A3 peptide enhances intestinal MUC3 expression and inhibits EPEC adherence.Q40680713
Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpressionQ40682731
Activation of mucin exocytosis and upregulation of MUC genes in polarized human intestinal mucin-secreting cells by the thiol-activated exotoxin listeriolysin O.Q40711330
Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis.Q40711507
The structure and regulation of tight junctionsQ40780311
Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells.Q40797367
A heat labile soluble factor from Bacteroides thetaiotaomicron VPI-5482 specifically increases the galactosylation pattern of HT29-MTX cellsQ40813269
Listeriolysin O-induced stimulation of mucin exocytosis in polarized intestinal mucin-secreting cells: evidence for toxin recognition of membrane-associated lipids and subsequent toxin internalization through caveolaeQ40826465
Genetics of bacteriocins produced by lactic acid bacteriaQ40858745
Tight junctions are membrane microdomainsQ40886204
Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretionsQ40892367
Induction of human beta-defensin-2 mRNA expression by Helicobacter pylori in human gastric cell line MKN45 cells on cag pathogenicity islandQ40924698
Fimbriae- and flagella-mediated association with and invasion of cultured epithelial cells by Salmonella enteritidisQ40946895
Purinergic and cholinergic agonists induce exocytosis from the same granule pool in HT29-Cl.16E monolayers.Q40961386
Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression.Q40961532
Human mucin glycoproteins: varied structures predict diverse properties and specific functionsQ41001407
Regulation of mucin exocytosis from intestinal goblet cellsQ41001426
Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cellsQ34853145
Bacteriocin diversity: ecological and evolutionary perspectivesQ34992663
The regulation of microcin B, C and J operons.Q34992710
Cell to cell communication by autoinducing peptides in gram-positive bacteriaQ35007700
Cell signaling through membrane mucinsQ35036941
The functions of mucosal T cells in containing the indigenous commensal flora of the intestineQ35060048
Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimuriumQ35107765
Microbial pathogenesis and cytoskeletal function.Q35109715
Intestinal M cells and their role in bacterial infectionQ35130619
Antibacterial effect of the adhering human Lactobacillus acidophilus strain LBQ35136011
Functional analysis of tight junctionsQ35150365
Quorum sensing and expression of virulence in Escherichia coli O157:H7.Q35156090
Pathological interactions of bacteria and toxins with the gastrointestinal epithelial tight junctions and/or the zonula adherens: an update.Q35168453
Molecular analysis of the composition of the bifidobacterial and lactobacillus microflora of humans.Q35196131
The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivoQ35202986
Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activityQ35361878
Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel diseaseQ35362664
Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: antibacterial effect of hBD-2 against Helicobacter pyloriQ35365183
Mucin gene expression in intestinal epithelial cells in Crohn's diseaseQ35365318
Intestinal microflora and homeostasis of the mucosal immune response: implications for probiotic bacteria?Q35540646
Bacteroides thetaiotaomicron: a dynamic, niche‐adapted human symbiontQ35541301
Bacterial pathogenesis: exploiting cellular adherenceQ35547387
Broad-spectrum antimicrobial activity of human intestinal defensin 5.Q35549706
Role of Toll-like receptors in pathogen recognition.Q35558810
α-Defensins in the gastrointestinal tractQ35563987
Cathelicidin family of antimicrobial peptides: proteolytic processing and protease resistanceQ35582184
Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological featuresQ35586790
Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour?Q35634287
The differentiating intestinal epithelial cell: establishment and maintenance of functions through interactions between cellular structuresQ35651713
Trypsin-dependent production of an antibacterial substance by a human Peptostreptococcus strain in gnotobiotic rats and in vitroQ35681748
Mucins and mucin binding proteins in colorectal cancerQ35682100
Innate immunity via Toll-like receptors and Nod proteinsQ35702964
Cell-to-cell signaling in intestinal pathogens.Q35728492
Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF miceQ50101740
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA.Q50101913
Displacement of bacterial pathogens from mucus and Caco-2 cell surface by lactobacilli.Q50102772
Lack of flagella disadvantages Salmonella enterica serovar Enteritidis during the early stages of infection in the rat.Q50106162
Contribution of flagella and invasion proteins to pathogenesis of Salmonella enterica serovar enteritidis in chicksQ50112117
The antibacterial action of microcin J25: evidence for disruption of cytoplasmic membrane energization in Salmonella newportQ50112123
Salmonella enteritidis FliC (flagella filament protein) induces human beta-defensin-2 mRNA production by Caco-2 cellsQ50115124
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
Adhesion of Salmonella enterica var Enteritidis strains lacking fimbriae and flagella to rat ileal explants cultured at the air interface or submerged in tissue culture mediumQ50119948
Inactivation of the flagellin gene of Salmonella enterica serotype enteritidis strongly reduces invasion into differentiated Caco-2 cellsQ50121609
Intestinal mucins: the binding sites for Salmonella typhimuriumQ50122010
Inhibition of pathogenic Salmonella enteritidis growth mediated by Escherichia coli microcin J25 producing strainsQ50122214
Purification and primary structure of murine cryptdin-1, a Paneth cell defensinQ50176329
Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine.Q51569667
Neural mediation of cholera toxin-induced mucin secretion in the rat small intestine.Q51648604
Intestinal epithelial-mesenchymal cell interactions.Q52179995
Variation in human intestinal microbiota with age.Q53953828
Identification of a Clostridium cocleatum strain involved in an anti-Clostridium difficile barrier effect and determination of its mucin-degrading enzymes.Q54240074
Taxonomic Lactobacillus Composition of Feces from Human Newborns during the First Few DaysQ54306254
[Transfer of the cecal flora of the hamster to the germfree C3H mouse: use of this model to study the flora of the anti-Clostridium difficile barrier]Q54433308
Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model system.Q54474693
Penetration and interactions of the antimicrobial peptide, microcin J25, into uncharged phospholipid monolayers.Q54488890
Inhibitory effect of probiotic Escherichia coli strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent-invasive E. coli strains isolated from patients with Crohn's disease.Q54522199
Bifidobacterium cell wall proteins induced beta-defensin 2 mRNA expression in human intestinal epithelial cellsQ54568547
Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli.Q54638065
Effect of antibiotic class and concentration on the release of lipopolysaccharide from Escherichia coli.Q54656237
A New Monoclonal Antibody Demonstrates That Muc4, the Intramembrane Ligand for Erbb2/Her2/Neu, Is Overexpressed in Multiple Carcinomas.Q55436393
Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulatorQ57940216
Tight junction proteins1This review is dedicated to the memory of Thomas Kreis.1Q58098084
The Essential Role of the Intestinal Microbiota in Facilitating Acute Inflammatory ResponsesQ58227634
MUC1 mucin mRNA expression in stage I lung adenocarcinoma and its association with early recurrenceQ58454736
Notch signals control the fate of immature progenitor cells in the intestineQ59048442
Pro-inflammatory Cytokines Up-regulate MUC1 Gene Expression in Oral Epithelial CellsQ59790040
Crowd control: quorum sensing in pathogenic E. coliQ60584791
SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7Q61857106
Epithelial inflammation response induced by Shigella flexneri depends on mucin gene expressionQ62660208
Separation of cholera enterotoxin-induced mucus secretion from electrolyte secretion in rabbit ileum by acetazolamide, colchicine, cycloheximide, cytochalasin B and indomethacinQ71067315
Human mucin genes: genomic organization and expression of MUC4, MUC5AC and MUC5BQ71130718
Bacteriocins of gram-positive bacteriaQ71852767
Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitisQ78766823
The MUC5AC Glycoprotein is the Primary Receptor for Helicobacter pylori in the Human StomachQ79137100
Host anti-microbial response to Helicobacter pylori infectionQ79185625
Cholera-induced mucin secretion from rat intestine: lack of effect of cAMP, cycloheximide, VIP, and colchicineQ72388101
Microflora modulates endocrine cells in the gastrointestinal mucosa of the ratQ72718175
Protein kinase-A-mediated secretion of mucin from human colonic epithelial cellsQ73134393
[In vitro antibacterial activity of faropenem, a novel oral penem antibiotic, against enterohemorrhagic Escherichia coli O157 strains]Q73249368
Antimicrobial activity of a 14-residue peptide against Escherichia coli O157:H7Q73265313
Colonic mucin discharge by a cholinergic agonist, prostaglandins, and peptide YY in the isolated vascularly perfused rat colonQ73325652
Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosaQ73335460
Food supplementation with milk fermented by Lactobacillus casei DN-114 001 protects suckling rats from rotavirus-associated diarrheaQ73513787
Inhibition of gastric mucin synthesis by Helicobacter pyloriQ73838428
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteriaQ73919528
Action of antimicrobial peptides: two-state modelQ74061744
Binding of enterotoxigenic Escherichia coli to isolated enterocytes and intestinal mucusQ74088224
Identification of genes involved in mucosal defense and inflammation associated with normal enteric bacteriaQ74227983
Antibiotic-induced release of endotoxin: in-vitro comparison of meropenem and other antibioticsQ74418719
Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritisQ74428266
Binding of Shigella to rat and human intestinal mucinQ74453058
Inhibition of in vitro growth of Shiga toxin-producing Escherichia coli O157:H7 by probiotic Lactobacillus strains due to production of lactic acidQ74483659
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel diseaseQ74593708
Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystemQ74626882
Microbial-host interactions specifically control the glycosylation pattern in intestinal mouse mucosaQ74634379
Colonization of microflora in mice: mucosal defense against luminal bacteriaQ77329043
Studying M cells and their role in infectionQ77432410
[Physiology of microflora in the digestive tract]Q77654426
Nitric oxide: a regulator of mucosal defense and injuryQ77683588
The intestinal microflora regulates cytokine production positively in spleen-derived macrophages but negatively in bone marrow-derived macrophagesQ78224116
Lactobacillus plantarum reduces the in vitro secretory response of intestinal epithelial cells to enteropathogenic Escherichia coli infectionQ78293150
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectantimicrobial peptideQ1201508
P304page(s)315-337
P577publication date2006-04-01
P1433published inClinical Microbiology ReviewsQ5133777
P1476titleThe front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota
P478volume19

Reverse relations

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Q36780412Urinary proteome analysis of irritable bowel syndrome (IBS) symptom subgroups
Q36375028Using unfixed, frozen tissues to study natural mucin distribution
Q63213123Vaccination Against Fungal Diseases: Lessons from Candida albicans
Q28483996Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus
Q42218324Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation.
Q34361733Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans
Q38219180Yacon (Smallanthus sonchifolius): a food with multiple functions

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