Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction

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Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.166.2.1248
P698PubMed publication ID11145708
P5875ResearchGate publication ID12183056

P2093author name stringA L Salzman
C Szabó
G Ross
L Virág
F G Soriano
L Liaudet
T Eaves-Pyles
K Murthy
P2860cites workDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
systemic inflammationQ7663815
circulatory systemQ11068
P304page(s)1248-1260
P577publication date2001-01-01
P1433published inJournal of ImmunologyQ3521441
P1476titleFlagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction
P478volume166

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cites work (P2860)
Q36371497A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease
Q34301259A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity
Q37478775A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity
Q35783945A live Salmonella enterica serovar Enteritidis vaccine allows serological differentiation between vaccinated and infected animals
Q91623453A multiepitopic theoretical fusion construct based on in-silico epitope screening of known vaccine candidates for protection against wide range of enterobacterial pathogens
Q39988803A universal epitope-based influenza vaccine and its efficacy against H5N1.
Q40525045Adjuvant role of Pseudomonas flagellin for Acinetobacter baumannii biofilm associated protein
Q46762426Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression
Q54638065Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli.
Q40215456Altered postnatal lung development in C3H/HeJ mice
Q34769152An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
Q42792380An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
Q43764532Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages
Q34153380Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice.
Q43807014Bacterial flagellin inhibits T cell receptor-mediated activation of T cells by inducing suppressor of cytokine signalling-1 (SOCS-1).
Q33609732Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Q28573976Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction
Q38634734Bacterial flagellin-a potent immunomodulatory agent.
Q43751490Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice
Q39392310Bordetella bronchiseptica flagellin is a proinflammatory determinant for airway epithelial cells
Q41996760Burkholderia mallei and Burkholderia pseudomallei stimulate differential inflammatory responses from human alveolar type II cells (ATII) and macrophages
Q43216096Candidate genes for resistance to Salmonella enteritidis colonization in chickens as detected in a novel genetic cross
Q40697264Cdc42 and Rac1 regulate late events in Salmonella typhimurium-induced interleukin-8 secretion from polarized epithelial cells
Q47218735Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity
Q36619670Circulating Biomarkers of Gut Barrier Function: Correlates and Nonresponse to Calcium Supplementation among Colon Adenoma Patients
Q37216534Cloning, Expression, and Purification of Pseudomonas aeruginosa Flagellin, and Characterization of the Elicited Anti-Flagellin Antibody.
Q34116277Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide
Q30434266Contribution of Burkholderia cenocepacia flagella to infectivity and inflammation
Q37521688Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection
Q42043676Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia.
Q22242645Defects in mucosal immunity leading to Crohn's disease
Q58838230Demodex-associated bacterial proteins induce neutrophil activation
Q34723287Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome
Q50105130Development of a mucosal complex vaccine against oral Salmonella infection in mice
Q34085571Diesel exhaust particles override natural injury-limiting pathways in the lung.
Q42112729Differential utilization of nuclear factor-kappaB signaling pathways for gingival epithelial cell responses to oral commensal and pathogenic bacteria
Q36071679Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5
Q40046693During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems
Q36240129Effects of flagellin on innate and adaptive immunity
Q33597094Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium
Q54332206Escherichia coli flagellin stimulates pro-inflammatory immune response.
Q36333189Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
Q64448327Fimbrial Protein FimH Is Involved in Expression of Proinflammatory Cytokines in a Toll-Like Receptor 4-Dependent Manner
Q37987493Flagella and bacterial pathogenicity
Q34757086Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice
Q34532966Flagella from five Cronobacter species induce pro-inflammatory cytokines in macrophage derivatives from human monocytes
Q40633168Flagellin Is the Major Proinflammatory Determinant of Enteropathogenic Salmonella
Q35057556Flagellin as carrier and adjuvant in cocaine vaccine development
Q42812093Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions
Q40763973Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses
Q34853145Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cells
Q34671311Flagellin perception: a paradigm for innate immunity
Q33949995Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells.
Q34681201Flagellin-independent regulation of chemokine host defense in Campylobacter jejuni-infected intestinal epithelium
Q40202304Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells.
Q37671627Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
Q64987920Functional expression of TLR5 of different vertebrate species and diversification in intestinal pathogen recognition.
Q39318238Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells
Q37426304Host and bacterial factors affecting induction of immune responses to flagellin expressed by attenuated Salmonella vaccine strains
Q36659908How flagellin and toll-like receptor 5 contribute to enteric infection
Q64127832IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells
Q44489945Identification and characterization of a novel Bacillus subtilis strain with potent antifungal activity of a flagellin-like protein
Q40614205Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro
Q33799493Identification of immunoreactive secretory proteins from the stationary phase culture of Burkholderia pseudomallei.
Q33846572Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses
Q36447409Immune-neural connections: how the immune system's response to infectious agents influences behavior
Q40388090Immunogenicity and anti-Burkholderia pseudomallei activity in Balb/c mice immunized with plasmid DNA encoding flagellin
Q58594624Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin
Q40271313Immunological characterization of recombinant Salmonella enterica serovar Typhi FliC protein expressed in Escherichia coli
Q39537395In Silico and In Vitro Studies of Truncated Forms of Flagellin (FliC) of Enteroaggregative Escherichia coli (EAEC).
Q41761349Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin.
Q53851473Induction of protective immunity by Legionella pneumophila flagellum in an A/J mouse model.
Q33631244Innate immune recognition of flagellin limits systemic persistence of Brucella
Q46915077Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin
Q35794610Intestinal epithelial cell regulation of mucosal inflammation
Q35065323Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
Q36209694Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury
Q33496572Involvement of SPI-2-encoded SpiC in flagellum synthesis in Salmonella enterica serovar Typhimurium
Q35033757Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
Q44493184Involvement of intestinal inducible nitric oxide synthase (iNOS) in the early stages of murine salmonellosis
Q91838920Lactic acid bacteria decrease Salmonella enterica Javiana virulence and modulate host inflammation during infection of an intestinal epithelial cell line
Q41977863Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro.
Q83499106Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice
Q34031547Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism
Q50081378Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella
Q33511278Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines
Q37582895Mucosal administration of flagellin induces innate immunity in the mouse lung
Q45021651Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice
Q37099478Mycoplasma genitalium-encoded MG309 activates NF-kappaB via Toll-like receptors 2 and 6 to elicit proinflammatory cytokine secretion from human genital epithelial cells
Q37264192Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines
Q35121965Pathogenic strains of Acanthamoeba are recognized by TLR4 and initiated inflammatory responses in the cornea.
Q36426836Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines
Q33340438Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma
Q64092770Physical Extraction and Fast Protein Liquid Chromatography for Purifying Flagella Filament From Uropathogenic for Immune Assay
Q35783003Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells
Q44617376Pretreatment with anti-flagellin serum delays acute lung injury in rats with sepsis
Q37353574Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production
Q40096795Protective role of Hemidesmus indicus R. Br. root extract against Salmonella typhimurium-induced cytotoxicity in Int 407 cell line
Q89093433Proteus spp. as Putative Gastrointestinal Pathogens
Q40618435Pseudomonas aeruginosa Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5
Q35176918Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice
Q39817421Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis.
Q37713228Repression of flagella is a common trait in field isolates of Salmonella enterica serovar Dublin and is associated with invasive human infections
Q46809881Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8.
Q34368121Roles of Toll-like receptors in innate immune responses
Q40379918Roles of specific amino acids in the N terminus of Pseudomonas aeruginosa flagellin and of flagellin glycosylation in the innate immune response
Q36867496Salmonella-induced enteritis: molecular pathogenesis and therapeutic implications
Q42466865Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss).
Q33963113Shiga toxin 2 and flagellin from shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activation
Q40433354Signal transduction in Campylobacter jejuni-induced cytokine production
Q38583148Small Wonders-The Use of Nanoparticles for Delivering Antigen
Q24628830Structural basis of TLR5-flagellin recognition and signaling
Q40625136Synthetic Cystic Fibrosis Sputum Medium Regulates Flagellar Biosynthesis through the flhF Gene in Burkholderia cenocepacia
Q41128427TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice
Q28240172TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
Q34139977Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development
Q40753377The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells
Q42155219The essential protein for bacterial flagella formation FlgJ functions as a β-N-acetylglucosaminidase
Q34647328The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota
Q33658800The hemorrhagic coli pilus (HCP) of Escherichia coli O157:H7 is an inducer of proinflammatory cytokine secretion in intestinal epithelial cells
Q29622909The immunopathogenesis of sepsis
Q35166988The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases
Q34636651The role of flagella and chemotaxis genes in host pathogen interaction of the host adapted Salmonella enterica serovar Dublin compared to the broad host range serovar S. Typhimurium.
Q41997378The role of major virulence factors of AIEC involved in inflammatory bowl disease-a mini-review.
Q34980255The standardized herbal formula, PM014, ameliorated cigarette smoke-induced lung inflammation in a murine model of chronic obstructive pulmonary disease.
Q50081086Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice
Q36764359Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis
Q34740026Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis.
Q36483050Toll-like receptors and corneal innate immunity
Q82973353Toll-like receptors and the eye
Q37564607Toll-like receptors and their role in gastrointestinal disease.
Q28209227Toll-like receptors as adjuvant receptors
Q29615190Toll-like receptors: critical proteins linking innate and acquired immunity
Q34493051Toll-like receptors: key mediators of microbe detection.
Q49021488Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection
Q30309845Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5.
Q44787283Within-species flagellin polymorphism in Xanthomonas campestris pv campestris and its impact on elicitation of Arabidopsis FLAGELLIN SENSING2-dependent defenses

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