Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury

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Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1166770G
P356DOI10.1371/JOURNAL.PONE.0166770
P932PMC publication ID5131931
P698PubMed publication ID27907005

P50authorRichard B PylesQ59688774
Tonyia Eaves-PylesQ114751016
P2093author name stringCsaba Szabo
Aaron L Miller
Gabor Olah
Allie Doyle
Logan Grimes
Sarah Hoskins
P2860cites workGut-derived mesenteric lymph: a link between burn and lung injury.Q50515235
Gut failure and translocation following burn and sepsis.Q54199908
Granulocyte colony-stimulating factor enhances killing of translocated bacteria but does not affect barrier function in a burn mouse model.Q54576171
Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's diseaseQ57307944
Distribution and survival of Escherichia coli translocating from the intestine after thermal injuryQ70166805
Intestinal permeability after severe trauma and hemorrhagic shock is increased without relation to septic complicationsQ70621186
Active Crohn's disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal floraQ80123941
Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patientsQ81768488
Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptorsQ24629037
Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cellsQ24805624
Gut inflammation and immunity: what is the role of the human gut virome?Q26822006
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
The causes of intestinal dysbiosis: a reviewQ28272103
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall componentsQ28511151
Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunctionQ28573976
Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in miceQ28743887
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasisQ29547656
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
Pathophysiologic response to severe burn injuryQ33369410
Microbes, the gut and ankylosing spondylitisQ33765449
Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanismQ34031547
Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharideQ34116277
Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice.Q34153380
Role of the gut lymphatic system in multiple organ failureQ34261847
Resident viruses and their interactions with the immune systemQ34351768
Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5.Q34519757
Dynamics of gut microbiota in autoimmune lupusQ34595444
Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activationQ34726793
Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts.Q35045292
Role of flagellin in the pathogenesis of shock and acute respiratory distress syndrome: therapeutic opportunitiesQ35052406
The gut microbiota and inflammatory bowel diseaseQ35446516
Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signalingQ35677449
Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial TranslocationQ35685953
Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epitheliumQ35788690
Role of primary human alveolar epithelial cells in host defense against Francisella tularensis infectionQ35949657
Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a reviewQ36251015
Burns, bacterial translocation, gut barrier function, and failureQ36252921
Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in miceQ36473188
Temporal cytokine profiles in severely burned patients: a comparison of adults and childrenQ36714067
Noninvasive measurement of intestinal inflammation after burn injuryQ36948314
Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarizationQ37484450
New Serologic Markers for Inflammatory Bowel Disease DiagnosisQ37798392
Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cellsQ40075088
Antibodies raised against N'-terminal Pseudomonas aeruginosa flagellin prevent mortality in lethal murine models of infection.Q40412459
A thermal injury-induced circulating factor(s) compromises intestinal cell morphology, proliferation, and migrationQ40941557
Suppression of Clostridium difficile in the gastrointestinal tracts of germfree mice inoculated with a murine isolate from the family LachnospiraceaeQ41585242
Brief Report: Intestinal Dysbiosis in Ankylosing SpondylitisQ41652119
The process of microbial translocationQ42481884
Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategyQ43050101
The time course of cardiac NF-kappaB activation and TNF-alpha secretion by cardiac myocytes after burn injury: contribution to burn-related cardiac contractile dysfunctionQ43960162
Flagellin treatment protects against chemicals, bacteria, viruses, and radiationQ50061502
Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsisQ50105381
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectsystemic inflammationQ7663815
dysbiosisQ269334
P304page(s)e0166770
P577publication date2016-12-01
P1433published inPLOS OneQ564954
P1476titleIntraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury
P478volume11

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cites work (P2860)
Q42329673Correction: Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury
Q91909936Edaravone reduces oxidative stress and intestinal cell apoptosis after burn through up-regulating miR-320 expression
Q53174825MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5.
Q39421565The influence of the commensal microbiota on distal tumor-promoting inflammation.

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