How flagellin and toll-like receptor 5 contribute to enteric infection

scientific article published on 21 November 2006

How flagellin and toll-like receptor 5 contribute to enteric infection is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1128/IAI.01506-06
P932PMC publication ID1828527
P698PubMed publication ID17118981

P50authorTheodore S SteinerQ56477374
P2860cites workFlagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cellsQ24805624
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunityQ25257710
Structure of the bacterial flagellar protofilament and implications for a switch for supercoilingQ27630815
Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cellsQ28179206
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motilityQ28185475
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expressionQ28211358
Evasion of Toll-like receptor 5 by flagellated bacteriaQ28256503
Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory responseQ28345391
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via IpafQ28506503
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesQ28594887
Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells.Q30305779
Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5.Q30309845
Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathwaysQ30436048
Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells.Q30471492
Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell lineQ32105902
High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activationQ33591155
Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes.Q33877245
Potent immunoregulatory effects of Salmonella typhi flagella on antigenic stimulation of human peripheral blood mononuclear cellsQ34000655
Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolQ34008981
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.Q34015833
A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunityQ34301259
Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulenceQ34507198
Flagellin-independent regulation of chemokine host defense in Campylobacter jejuni-infected intestinal epitheliumQ34681201
Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated miceQ34757086
Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cellsQ34853145
Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and hostQ34935646
Toll-like receptor-5 and the innate immune response to bacterial flagellin.Q35017544
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infectionQ35060264
The attenuated phenotype of a Salmonella typhimurium flgM mutant is related to expression of FliC flagellinQ35607546
Flagella help Salmonella typhimurium survive within murine macrophagesQ37043118
Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infectionQ37521688
Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitisQ39391975
Structural study of binding of flagellin by Toll-like receptor 5.Q39787971
Salmonella typhimurium coordinately regulates FliC location and reduces dendritic cell activation and antigen presentation to CD4+ T cellsQ40236117
Roles of specific amino acids in the N terminus of Pseudomonas aeruginosa flagellin and of flagellin glycosylation in the innate immune responseQ40379918
Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to toll-like receptor 5.Q40474807
Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathwayQ40499553
In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strainQ40526966
Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5.Q40608367
Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitroQ40614205
Pseudomonas aeruginosa Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5Q40618435
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexesQ40641430
Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the proteinQ40764434
Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitisQ41785768
The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.Q45232038
Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8.Q46809881
Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunityQ47661604
Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellinQ47810062
Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophilaQ48269403
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.Q50079058
Activation, cytokine production, and intracellular survival of bacteria in Salmonella-infected human monocyte-derived macrophages and dendritic cellsQ50088601
Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1.Q50096687
Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative FlagellinQ50104203
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.Q53944716
Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli.Q54638065
Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory CellsQ57447880
Plants have a sensitive perception system for the most conserved domain of bacterial flagellinQ77908621
Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellinQ81544572
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P1104number of pages8
P304page(s)545-552
P577publication date2006-11-21
P1433published inInfection and ImmunityQ6029193
P1476titleHow flagellin and toll-like receptor 5 contribute to enteric infection
P478volume75

Reverse relations

cites work (P2860)
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