Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells. (scientific article published on 30 November 2006)

Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells

Q24805624

Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin

Q28201436

Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide

Q28207950

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

Q28211358

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

Q28345391

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

Q28611075

Negative regulation of toll-like receptor-mediated immune responses

Q29619019

Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors

Q33885735

Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome

Q33892692

Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue

Q34221026

The epithelial cell cytoskeleton and intracellular trafficking. V. Polarized compartmentalization of antigen processing and Toll-like receptor signaling in intestinal epithelial cells

Q34838371

PI3K and negative regulation of TLR signaling.

Q35177702

Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?

Q35565556

Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease

Q35594445

Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium

Q35788690

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

Q36363455

Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells

Q36370326

Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils

Q36383341

Bacterial flagellin is a dominant antigen in Crohn disease.

Q37698878

Structure, biochemistry, and assembly of epithelial tight junctions

Q39688977

Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression.

Q40366293

A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells.

Q40466482

In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain

Q40526966

Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein

Q40534456

Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells

Q40571187

Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk

Q40609296

TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism

Q40654277

Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components

Q40681768

Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5.

Q40738252

The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells

Q40753377

Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling

Q40836924

Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells

Q40879729

Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression

Q42488328

Elevated flagellin-specific immunoglobulins in Crohn's disease

Q50096591

A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways

Q50108850

Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction

Q50117610

P433

issue

P921

main subject

toll-like receptor

Q408004

P304

page(s)

G767-78

P577

publication date

2006-11-30

P1433

published in

American Journal of Physiology - Gastrointestinal and Liver Physiology

Q15765756

P1476

title

Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells

P478

volume

292

Reverse relations

cites work (P2860)

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