The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases

scientific article

The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00430-003-0186-X
P698PubMed publication ID12836019
P5875ResearchGate publication ID10682634

P50authorChristoph HölscherQ91743109
P2860cites workHost defense mechanisms triggered by microbial lipoproteins through toll-like receptorsQ22010442
Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12Q22254620
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12Q24290619
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cellsQ24295111
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RQ24297906
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activityQ24306484
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12Q24306559
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytesQ24315666
Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunitQ24316432
Regulation of virus-induced IL-12 and IL-23 expression in human macrophagesQ24317251
Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genesQ24317746
Cloning and characterization of a novel class I cytokine receptorQ24319055
Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130Q24319312
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patientsQ24320044
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunitsQ24323368
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cellsQ24338229
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cellsQ24338274
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factorQ24338518
Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejectionQ24630780
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areasQ24652833
Selective expression of an interleukin-12 receptor component by human T helper 1 cellsQ24670175
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cellsQ24678409
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha productionQ24679477
Direct interaction of STAT4 with the IL-12 receptorQ28140322
Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5Q28183804
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature deathQ28199430
A unique role for IL-23 in promoting cellular immunityQ28202873
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cellsQ28214882
Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiencyQ28218735
Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunitQ28274546
Cloning of a new cytokine that induces IFN-gamma production by T cellsQ28283928
Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptorQ28290291
Identification of a STAT4 binding site in the interleukin-12 receptor required for signalingQ28294067
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesQ28295404
Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinasesQ28303959
Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonistQ28306642
Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cellsQ28344650
Development of Th1-type immune responses requires the type I cytokine receptor TCCRQ28591931
STATs and gene regulationQ29547796
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathwaysQ29616209
Functional diversity of helper T lymphocytesQ29619415
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunityQ29619700
Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient miceQ33597343
IL-12 receptor. II. Distribution and regulation of receptor expressionQ41624128
Molecular characterization of interleukin 12Q41633083
Cytokines induce the development of functionally heterogeneous T helper cell subsetsQ41732572
Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathologyQ41835746
Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situQ42491827
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signalQ42834238
Defective NK cell activity and Th1 response in IL-18-deficient miceQ43595287
Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signalingQ44092276
Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is presentQ44197418
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cellsQ44217456
Mice lacking IL-12 develop polarized Th1 cells during viral infectionQ44244442
Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosisQ44281901
Selective suppression of IL-12 production by chemoattractantsQ44963436
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingQ45069275
A protective and agonistic function of IL-12p40 in mycobacterial infection.Q46435226
Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice.Q47936535
Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genesQ48063953
IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidisQ50112612
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
In vivo production and function of IL-12 p40 homodimers.Q50134634
Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers.Q50335934
The role of Stat4 in species-specific regulation of Th cell development by type I IFNs.Q52181256
IL-12-deficient mice are defective but not devoid of type 1 cytokine responses.Q52199362
Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.Q52520769
IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.Q52539822
NEMO/IKK gamma-deficient mice model incontinentia pigmenti.Q52540121
IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18.Q53994536
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.Q54195040
IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic CellsQ62589132
Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1)Q62589133
IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytesQ64380945
Sequence similarity between NKSF and the IL-6/G-CSF familyQ67535195
Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformansQ39573339
In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.Q39654574
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient miceQ40442637
Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytesQ40651348
C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages.Q40739719
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent eventQ40818385
Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligationQ40820410
Biosynthesis and posttranslational regulation of human IL-12.Q40884157
JNK2 and IKKbeta are required for activating the innate response to viral infectionQ40907787
Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcriptionQ40907803
The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasisQ41019227
Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells.Q41025204
Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells.Q41034502
Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.Q41052237
Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.Q41115495
Molecular cloning and characterization of murine IL-12 genes.Q41236121
Innate immunity: impact on the adaptive immune responseQ41353080
Signaling and transcription in T helper developmentQ33932729
The role of interleukin-13 in infectious diseases and allergyQ33957353
Lineage commitment in the immune system: the T helper lymphocyte grows up.Q33970744
The Stat family in cytokine signalingQ34180677
Regulation of interleukin-12 production by G-protein-coupled receptorsQ34184407
Cloning and expression of murine IL-12Q34242875
Immune responses to intracellular bacteria.Q34332652
The instructive role of innate immunity in the acquired immune responseQ34375203
IFN-gamma production by antigen-presenting cells: mechanisms emerge.Q34382913
Regulation of interleukin-12 production in antigen-presenting cellsQ34419549
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient miceQ34430392
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosisQ34431001
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiencyQ34469625
Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10.Q34473047
Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shockQ35558615
Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblastsQ35788425
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytesQ36356764
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cellsQ36362214
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4Q36364774
Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infectionQ36368062
Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cellsQ36368860
c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.Q36369604
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.Q36370082
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondiiQ36377044
Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4.Q36401302
Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase responseQ36559345
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteinsQ36570254
Cloning and characterization of a mouse IL-12 receptor-beta componentQ36685546
The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challengeQ37227569
Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient miceQ37696753
Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2).Q38297725
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophagesQ38299607
IL-12 expression in AIDS-related lymphoma B cell lines.Q38361706
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthaseQ39570411
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNAQ68033053
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cellsQ70801399
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responsesQ71079171
The interleukin-12 beta subunit (p40) maps to mouse chromosome 11Q71140988
Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3Q71140991
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infectionQ71727838
Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivoQ71871092
Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cellsQ71968307
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cellsQ72191659
Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cellsQ72672991
Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiencyQ73022187
Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cellsQ73043254
IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sitesQ73209269
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathwayQ73330320
Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptideQ73330390
Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptorQ73588565
IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathologyQ73603855
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responsesQ73630439
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cellsQ74145377
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cellsQ74285101
Alloantigen-reactive Th1 development in IL-12-deficient miceQ74506164
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infectionQ74840049
IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenesQ77378930
Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infectionQ77399380
Requirement for type 2 NO synthase for IL-12 signaling in innate immunityQ77730607
IL-12 is not required for induction of type 1 cytokine responses in viral infectionsQ77899649
IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout miceQ78025445
Unresponsiveness of MyD88-deficient mice to endotoxinQ78093558
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)1-17
P577publication date2003-06-27
P1433published inMedical Microbiology and ImmunologyQ15760239
P1476titleThe power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases
P478volume193

Reverse relations

cites work (P2860)
Q33727236A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression
Q42540105Assessment of interleukin-12, gamma interferon, and tumor necrosis factor alpha secretion in sera from mice fed with dietary lipids during different stages of Listeria monocytogenes infection
Q64264328Association of IL-12 and TNF-α Polymorphisms with Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Q24796992Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27
Q39150741Burkholderia pseudomallei induces IL-23 production in primary human monocytes.
Q34504952Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation
Q41939112Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics
Q44655310EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation
Q37616351Early changes in cytokine expression in peste des petits ruminants disease
Q34240279Elevated levels of serum IL-12 and IL-18 are associated with lower frequencies of CD4(+)CD25 (high)FOXP3 (+) regulatory t cells in young patients with type 1 diabetes
Q34896078Epstein-Barr virus and rheumatoid arthritis: is there a link?
Q44059434Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus.
Q54513849High expression of Foxp3, IL-23p19 and survivin mRNA in colorectal carcinoma.
Q34279908Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23
Q39255947IL-12B and IL-10 gene polymorphisms in the development of Hashimoto's thyroiditis.
Q37777456IL-23: A Promising Therapeutic Target for Systemic Lupus Erythematosus
Q36784915IL27: its roles in the induction and inhibition of inflammation
Q81849214Immunostimulatory DNA activates production of type I interferons and interleukin-6 in equine peripheral blood mononuclear cells in vitro
Q45330845Increased T-cell activation and Th1 cytokine concentrations prior to the diagnosis of B-cell lymphoma in HIV infected patients
Q35914958Induction of RNA interference in dendritic cells
Q57735511Interleukin 27 is up-regulated in patients with active inflammatory bowel disease
Q35830335Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells
Q41769162Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner
Q41844885Macrophages isolated from chickens genetically resistant or susceptible to systemic salmonellosis show magnitudinal and temporal differential expression of cytokines and chemokines following Salmonella enterica challenge
Q45063970Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus
Q53263504Monocytes expression of IL-12 related and IL-10 genes in association with development of colorectal cancer.
Q42238460Phenotypic and functional maturation of murine dendritic cells induced by 18 alpha- and beta-glycyrrhetinic acid
Q35279724Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35
Q34248435Role of CD40 ligation in dendritic cell semimaturation
Q61758860Taq-I polymorphism in 3′UTR of the IL-12B and association with IL-12p40 production from human PBMC
Q34623345The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: a pilot study
Q54736608The influence of JNK and P38 MAPK inhibition on IL-12P40 and IL-23 production depending on IL12B promoter polymorphism.
Q33707467Trypanosomiasis-induced Th17-like immune responses in carp.

Search more.