Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation

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Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...748370B
P356DOI10.1371/JOURNAL.PONE.0048370
P932PMC publication ID3511462
P698PubMed publication ID23226202
P5875ResearchGate publication ID233888807

P2093author name stringTianxia Wu
Daniel S Reich
Mika Komori
Bibiana Bielekova
Quangang Xu
P2860cites workRecommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosisQ22252943
Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesisQ24300326
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activityQ24306484
The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravisQ24308609
IL-12: the role of p40 versus p75Q28213086
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging studyQ28290823
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node developmentQ28585776
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulationQ28585797
The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis.Q33611768
The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS).Q33654152
Analysis of biomarker data: logs, odds ratios, and receiver operating characteristic curvesQ33729360
CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilisQ33907970
Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.Q34363246
Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor β1.Q35141375
The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseasesQ35166988
Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patientsQ35585366
Intrathecal effects of daclizumab treatment of multiple sclerosisQ35635127
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesionsQ36365596
IL-12p40: an inherently agonistic cytokineQ36663486
The relation between inflammation and neurodegeneration in multiple sclerosis brains.Q37181308
IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1.Q37348848
Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosisQ37354974
Diagnostic accuracy and receiver-operating characteristics curve analysis in surgical research and decision makingQ37835793
Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course.Q39808939
IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizureQ40357894
Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid.Q42772808
IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1.Q42833249
Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS.Q43227358
The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivityQ44916973
Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection.Q45772138
Reduced T helper 1 responses in IL-12 p40 transgenic mice.Q47829367
Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cordsQ48099284
Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research GroupQ48180007
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.Q48200750
Approach to discriminate subgroups in multiple sclerosis with cerebrospinal fluid (CSF) basic inflammation indices and TNF-alpha, IL-1beta, IL-6, IL-8.Q48230312
Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alphaQ48427106
Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphomaQ48462130
Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitmentQ48701331
Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS.Q50971930
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Detection of MCP-1 and IL-8 in the serum and cerebrospinal fluid of a child with Miller Fisher syndrome.Q51608143
Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: involvement of p38 and JNK kinase pathways.Q54422001
BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo.Q55034944
Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluidQ59543689
Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjögren's syndromeQ60548220
Systematic microanatomical analysis of CXCL13 and CCL21in situ production and progressive lymphoid organization in rheumatoid synovitisQ60810884
IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. Possible involvement of IFN-gammaQ71555542
The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimerQ71782113
Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cellsQ71968307
Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patientsQ73311968
IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuriesQ75372669
Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndromeQ77179303
CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disordersQ80316283
Characterization of CXCL13+ neoplastic t cells in cutaneous lesions of angioimmunoblastic T-cell lymphoma (AITL)Q80528624
B-Cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13)Q81021721
Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albuminQ81355283
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosisQ81470272
Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluidQ82230939
Cerebrospinal fluid levels of CXCL13 are elevated in neuromyelitis opticaQ82254306
The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effectsQ82305649
Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70Q82661826
IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosisQ83900243
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcerebrospinal fluidQ54196
biomarkerQ864574
P304page(s)e48370
P577publication date2012-11-30
P1433published inPLOS OneQ564954
P1476titleCerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation
P478volume7

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cites work (P2860)
Q36894072Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients
Q55052878Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines.
Q47117780Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis.
Q47094091Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies
Q93209819Autism spectrum disorder and severe social impairment associated with elevated plasma interleukin-8
Q41236543Autologous Bone Marrow Transplantation in Multiple Sclerosis: Biomarker Relevance for Patient Recruitment and Follow up.
Q35364112Biomarkers of inflammation and axonal degeneration/damage in patients with newly diagnosed multiple sclerosis: contributions of the soluble CD163 CSF/serum ratio to a biomarker panel
Q35078327Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future
Q37271834CXCL13, CXCL10 and CXCL8 as Potential Biomarkers for the Diagnosis of Neurosyphilis Patients
Q47356888Cerebrospinal Fluid Cytokine Expression Profile in Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy.
Q34422726Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics
Q48737760Cerebrospinal fluid inflammatory markers in patients with multiple sclerosis: a pilot study.
Q49900631Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation
Q64957483Clinical utility of a molecular signature in inflammatory demyelinating disease.
Q24273331Comprehensive immunophenotyping of cerebrospinal fluid cells in patients with neuroimmunological diseases
Q57167230Delayed treatment of MS is associated with high CSF levels of IL-6 and IL-8 and worse future disease course
Q35848490Immune and Epstein-Barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis
Q34718044Intense inflammation and nerve damage in early multiple sclerosis subsides at older age: a reflection by cerebrospinal fluid biomarkers.
Q38774697Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids
Q47615874Molecular-based diagnosis of multiple sclerosis and its progressive stage
Q26753174Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease
Q61449501Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis
Q40962441Pharmacodynamic effects of daclizumab in the intrathecal compartment
Q38258595Point-of-care diagnostics, a major opportunity for change in traditional diagnostic approaches: potential and limitations
Q36188305Radiologically isolated syndrome: watchful waiting vs. active treatment
Q26852859Stage-specific immune dysregulation in multiple sclerosis
Q28255460Subclinical central inflammation is risk for RIS and CIS conversion to MS
Q38819421The cerebrospinal fluid in multiple sclerosis: far beyond the bands
Q92251928Utility of chemokines CCL2, CXCL8, 10 and 13 and interleukin 6 in the pediatric cohort for the recognition of neuroinflammation and in the context of traditional cerebrospinal fluid neuroinflammatory biomarkers

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