Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin

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Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin is …
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scholarly articleQ13442814

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P356DOI10.1038/S41426-018-0176-0
P932PMC publication ID6220273
P698PubMed publication ID30405111

P2093author name stringJian Yu
Man Xu
Yimou Wu
Kang Zheng
Yumeng Li
Feijun Zhao
Tiebing Zeng
Yongjian Xiao
Yafeng Xie
Manyi Tan
Haodang Luo
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A conserved TLR5 binding and activation hot spot on flagellinQ28818682
The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host CellsQ30152722
Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response.Q31904771
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Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatmentQ70225612
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Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesionsQ72603802
The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic CellsQ73361348
Isolation and laboratory maintenance of Treponema pallidumQ81928458
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Enhanced immune response and protective efficacy of a Treponema pallidum Tp92 DNA vaccine vectored by chitosan nanoparticles and adjuvanted with IL-2Q84975810
Treponema pallidum induces systemic TH17 and TH1 cytokine responsesQ85642853
High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activationQ33591155
Immunogenic properties of the protein component of Treponema pallidumQ33665284
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Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemesQ34525427
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Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilisQ35105151
High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilisQ35133876
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Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon productionQ35783879
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Can population differences explain the contrasting results of the Mwanza, Rakai, and Masaka HIV/sexually transmitted disease intervention trials?: A modeling studyQ35985936
Antigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenisQ36214510
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A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidumQ37630333
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Lesions of primary and secondary syphilis contain activated cytolytic T cellsQ39824504
Evaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilisQ40274959
Treponema pallidum flagellins elicit proinflammatory cytokines from human monocytes via TLR5 signaling pathway.Q40356934
Multifaceted immune responses and protective efficacy elicited by a recombinant autolyzed Salmonella expressing FliC flagellar antigen of F18(+)Escherichia coli.Q40462170
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IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human MacrophagesQ42373352
The pattern and level of cytokines secreted by Th1 and Th2 lymphocytes of syphilitic patients correlate to the progression of the diseaseQ43484336
Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiationQ44952549
Syphilis control--a continuing challengeQ44973312
Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes.Q45756366
Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK/NF-κB signaling pathways in human epidermal keratinocytesQ47690982
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectNew ZealandQ664
virologyQ7215
infectious diseaseQ18123741
immunologyQ101929
parasitologyQ180502
immunizationQ1415366
drug discoveryQ1418791
Treponema pallidumQ156007
P304page(s)177
P577publication date2018-11-07
P1433published inEmerging Microbes & InfectionsQ27724513
P1476titleImmunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin
P478volume7

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cites work (P2860)
Q97545395Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus
Q92781569PCR detection for syphilis diagnosis: Status and prospects
Q93165396The N-terminal D1 domain of Treponema pallidum flagellin binding to TLR5 is required but not sufficient in activation of TLR5

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