Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice

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Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...996165H
P356DOI10.1371/JOURNAL.PONE.0096165
P932PMC publication ID4039429
P698PubMed publication ID24879439
P5875ResearchGate publication ID262785067

P50authorEdmund K WallerQ59682183
Andrew T GewirtzQ100427123
P2093author name stringMohammad S Hossain
Sampath Ramachandiran
P2860cites workStructural basis of TLR5-flagellin recognition and signalingQ24628830
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionQ24633526
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Up on the tightrope: natural killer cell activation and inhibitionQ29619175
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host diseaseQ34304622
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate modelsQ34769152
Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in miceQ35094493
Development of murine hepatic NK cells during ontogeny: comparison with spleen NK cellsQ35606439
Cytokine dysregulation and acute graft-versus-host diseaseQ35607602
Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunityQ35691842
Effects of flagellin on innate and adaptive immunityQ36240129
Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/betaQ36370726
Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients.Q36709854
Murine cytomegalovirus regulation of NKG2D ligands.Q37079834
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.Q37671627
The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responsesQ37887501
All is fair in virus-host interactions: NK cells and cytomegalovirus.Q37919670
NAIPs: building an innate immune barrier against bacterial pathogens. NAIPs function as sensors that initiate innate immunity by detection of bacterial proteins in the host cell cytosolQ38003578
IFN-gamma production and degranulation are differentially regulated in response to stimulation in murine natural killer cellsQ40047510
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Immunotherapy of CMV infections.Q41117411
Activation and function of natural killer cell responses during viral infectionsQ41353152
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactionsQ42812093
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CD107a as a functional marker for the identification of natural killer cell activity.Q44415685
Specific and nonspecific NK cell activation during virus infectionQ44496692
Transplantation-related complications predicted by cytokine gene expression in the mixed lymphocyte culture in allogeneic bone marrow transplantsQ45116846
NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulationQ45304748
Flagellin delays spontaneous human neutrophil apoptosisQ50049660
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
Maturation of mouse NK cells is a 4-stage developmental program.Q50602171
Reduced p38 mitogen-activated protein kinase in donor grafts accelerates acute intestinal graft-versus-host disease in mice.Q50764045
CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells.Q51869989
Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease.Q51994114
In vivo developmental stages in murine natural killer cell maturation.Q52120129
The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activationQ56966801
Natural killer function following allogeneic bone marrow transplantation. Very early reemergence but strong dependence of cytomegalovirus infectionQ59194490
Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysisQ60556931
The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicityQ61911900
Cytomegalovirus pneumonitis occurring after allogeneic bone marrow transplantation: a study of 106 recipientsQ68080505
An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infectionsQ70890745
Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infectionQ71120565
Function and Regulation of Natural Killer (NK) Cells during Viral Infections: Characterization of Responses in VivoQ71544772
Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infectionQ73964596
Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infectionsQ77502609
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)e96165
P577publication date2014-05-30
P1433published inPLOS OneQ564954
P1476titleRecombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice
P478volume9

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cites work (P2860)
Q38733975Advances in Antiviral Therapies Targeting Toll-like Receptors
Q37702300Characterization of IFNγ-producing natural killer cells induced by cytomegalovirus reactivation after haploidentical hematopoietic stem cell transplantation
Q28075204Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives
Q55285439Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models.
Q38460376Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
Q38610456Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades
Q36771989The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism
Q64063113Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia
Q40302307Toll-like receptor 5 signaling restrains T-cell/natural killer T-cell activation and protects against concanavalin A-induced hepatic injury
Q36607439Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis

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