A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity

scientific article published on 14 January 2014

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...985587L
P356DOI10.1371/JOURNAL.PONE.0085587
P932PMC publication ID3891810
P698PubMed publication ID24454895
P5875ResearchGate publication ID259879546

P50authorAndrei V. GudkovQ52356947
P2093author name stringHong Liu
Guanglin Bian
Lyudmila G Burdelya
Nicholas D Leigh
Semra Aygun-Sunar
Xilai Ding
Xuefang Cao
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Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growthQ24620395
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonistQ24623979
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
Tolerance, danger, and the extended familyQ29547532
Toll-like receptors: critical proteins linking innate and acquired immunityQ29615190
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host diseaseQ34304622
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestisQ34334406
Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.Q53549440
Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivoQ56904232
Bacterial lipopolysaccharide, TNF-alpha, and calcium ionophore under serum-free conditions promote rapid dendritic cell-like differentiation in CD14+ monocytes through distinct pathways that activate NK-kappa BQ73084717
Real-time imaging of ligand-induced IKK activation in intact cells and in living miceQ81045070
Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flowQ82964586
NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivoQ83853093
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate modelsQ34769152
In vivo natural killer cell activities revealed by natural killer cell-deficient miceQ35080152
Role of Toll-like receptors in costimulating cytotoxic T cell responsesQ35141926
Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cellsQ36346159
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' DiseaseQ36371497
An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneumQ36401729
Signals required for programming effector and memory development by CD8+ T cellsQ36528952
Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88.Q37095534
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Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responsesQ39398295
Quantifying nuclear p65 as a parameter for NF-κB activation: Correlation between ImageStream cytometry, microscopy, and Western blotQ39552773
Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effectQ39683136
Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo.Q40065376
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearanceQ40071336
The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4.Q40172870
Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA.Q40225124
Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumorsQ40244018
Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancerQ40278179
Toll-like receptors mediate proliferation and survival of multiple myeloma cellsQ40291993
Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activityQ40524997
Intratumor CpG-Oligodeoxynucleotide Injection Induces Protective Antitumor T Cell ImmunityQ40628602
Establishment and characterization of BALB/c lymphoma lines with B cell propertiesQ40701007
MHC class I expression on tumor targets inhibits natural killer cell-mediated cytotoxicity without interfering with target recognitionQ41573185
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactionsQ42812093
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.Q43845859
Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type responseQ47578800
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.Q50079058
Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionQ50117610
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectlymphocyteQ715347
cytotoxicityQ246181
toll-like receptorQ408004
P304page(s)e85587
P577publication date2014-01-14
P1433published inPLOS OneQ564954
P1476titleA flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity
P478volume9

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cites work (P2860)
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