Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression

scientific article

Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0002-9440(10)62264-X
P3181OpenCitations bibliographic resource ID2986564
P932PMC publication ID1237049
P698PubMed publication ID15681825

P50authorW Vallen GrahamQ73205624
P2093author name stringJerrold R Turner
Yingmin Wang
Fengjun Wang
Brad T Schwarz
Edwina D Witkowski
P2860cites workSulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expressionQ28347747
Permeability of human HT-29/B6 colonic epithelium as a function of apoptosisQ28348796
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa BQ28379350
IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine bindingQ30467607
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's diseaseQ34145454
Effect of cytokines on the epithelial function of the human colon carcinoma cell line HT29 cl 19AQ34376559
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayersQ34567309
Loosening tight junctions. Lessons from the intestineQ34569725
Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctionsQ34786600
T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.Q34816745
A porous defense: the leaky epithelial barrier in intestinal disease.Q35651435
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.Q37208648
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanismsQ40614064
Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanismsQ40685684
Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial riskQ40735088
Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier functionQ40811303
Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cellsQ40838088
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and betaQ40845763
Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma.Q40880588
Tight junctions are membrane microdomainsQ40886204
Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actinQ40954070
Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6.Q40990210
Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeabilityQ41077484
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeabilityQ41151632
Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextransQ41387016
Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeabilityQ41597813
CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeabilityQ41663928
Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeabilityQ41738669
Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase productsQ42190722
Tumour Necrosis factor-α induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayersQ42479137
Long-term effects of tumor necrosis factor on LLC-PK1 transepithelial resistanceQ42503264
Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in miceQ42797638
Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3.Q43509902
Efficacy of use of colonoscopy in dextran sulfate sodium induced ulcerative colitis in rats: the evaluation of the effects of antioxidant by colonoscopyQ43679522
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drugQ43756729
Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransportQ43797549
An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanismQ43812071
Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymesQ44265345
TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activationQ44758263
Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha.Q51525902
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.Q53965794
PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase.Q54079243
Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis.Q54102357
The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusionQ63407202
INFLIXIMAB DOWNREGULATES INTERFERON-γ PRODUCTION IN ACTIVATED GUT T-LYMPHOCYTES FROM PATIENTS WITH CROHN'S DISEASEQ63727345
Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host diseaseQ64381640
Intestinal permeability and the prediction of relapse in Crohn's diseaseQ72220492
Antioxidant properties of aminosalicylatesQ72377087
Effect of FR167653 on small bowel ischemia-reperfusion injury in dogsQ73208385
Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransportQ73533349
Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shockQ73644807
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylationQ73847660
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)409-419
P577publication date2005-02-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleInterferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
P478volume166

Reverse relations

cites work (P2860)
Q406275741,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway
Q64267911A Role of Exopolysaccharide Produced by in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis
Q91473782A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function
Q27335631A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease
Q37459893AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function
Q35183535Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.
Q28472412Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
Q39292091Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1.
Q30476106Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis
Q46877467Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells
Q39782336Adherent-invasive Escherichia coli target the epithelial barrier
Q34813646Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase
Q26778947Alcohol and the Intestine
Q37037647Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
Q35895662Altered expression levels of occludin, claudin-1 and myosin light chain kinase in the common bile duct of pediatric patients with pancreaticobiliary maljunction
Q28487645Amelioration of IFN-γ and TNF-α-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway
Q92527296Anemia induces gut inflammation and injury in an animal model of preterm infants
Q50327258Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity
Q33780207Association of MYO9B gene polymorphisms with inflammatory bowel disease in Chinese Han population
Q37968876Bacteria and host interactions in the gut epithelial barrier
Q47110338Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium.
Q37116525Bacterial particle endocytosis by epithelial cells is selective and enhanced by tumor necrosis factor receptor ligands.
Q37018335Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad
Q33552613Balsalazine decreases intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice
Q36698786Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport
Q43117359Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism
Q38838522Bowel Radiation Injury: Complexity of the Pathophysiology and Promises of Cell and Tissue Engineering
Q34078011Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety
Q88994185Buckwheat and buckwheat enriched products exert an anti-inflammatory effect on the myofibroblasts of colon CCD-18Co
Q92668105Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis
Q41027551Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway
Q34582338CD137 signaling enhances tight junction resistance in intestinal epithelial cells
Q33788423Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
Q39308269Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease
Q36113266Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome.
Q37398298Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity
Q42492832Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression
Q38051015Chemotherapy-induced gut toxicity: are alterations to intestinal tight junctions pivotal?
Q36699701Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism
Q36026933Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome
Q92582586Cilostazol against 2,4,6-trinitrobenzene sulfonic acid-induced colitis: Effect on tight junction, inflammation, and apoptosis
Q28066092ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target
Q91971705Claudin Family Participates in the Pathogenesis of Inflammatory Bowel Diseases and Colitis-Associated Colorectal Cancer
Q36982054Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
Q39212748Claudin-2 regulates colorectal inflammation via myosin light chain kinase-dependent signaling.
Q38809387Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target.
Q64102152Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFNγ Production From Human Colonic ILC3s via Multiple Mechanisms
Q54400370Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity.
Q26861369Conceptual barriers to understanding physical barriers
Q89578153Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis
Q35052412Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
Q36704497Coupling between apical and paracellular transport processes
Q28079482Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability
Q34555811Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3.
Q101567971Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity
Q38666232Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-α related mechanism
Q37308566Cytokine regulation of tight junctions
Q41418721DT-13 Ameliorates TNF-α-Induced Vascular Endothelial Hyperpermeability via Non-Muscle Myosin IIA and the Src/PI3K/Akt Signaling Pathway
Q38834628Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation
Q89861763Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD
Q40495815Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state
Q91725417Dietary Chitin Particles Called Mimetic Fungi Ameliorate Colitis in Toll-Like Receptor 2/CD14- and Sex-Dependent Manners
Q99562875Dietary Supplementation with Spray-Dried Porcine Plasma Attenuates Colon Inflammation in a Genetic Mouse Model of Inflammatory Bowel Disease
Q39866527Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats
Q53539472Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis.
Q54346274Differential effects of nutritional and non-nutritional therapies on intestinal barrier function in an in vitro model.
Q42199563Differential partial activation phenotype and production of tumour necrosis factor-α by conventional dendritic cells in response to lipopolysaccharide in HIV+ viraemic subjects and HIV+ controllers
Q40186985Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
Q44001914Does endotoxaemia contribute to osteoarthritis in obese patients?
Q47806206Dynamic modeling of the tight junction pore pathway
Q43121604Dynamic properties of the tight junction barrier
Q46765488Dynamics of enterocyte tight junctions: effect of experimental colitis and two different anti-TNF strategies
Q27324323Early mucosal sensing of SIV infection by paneth cells induces IL-1β production and initiates gut epithelial disruption
Q46304503Effect of polyunsaturated fatty acids on tight junctions in a model of the human intestinal epithelium under normal and inflammatory conditions
Q43494464Effects of berberine on rat jejunal motility
Q38080687Effects of enteral nutrition on Crohn's disease: clues to the impact of diet on disease pathogenesis
Q57279542Enhanced Gastrointestinal Passive Paracellular Permeability Contributes to the Obesity-associated Hyperoxaluria
Q50092863Enteral Nutrition in the Management of Crohn's Disease: Reviewing Mechanisms of Actions and Highlighting Potential Venues for Enhancing the Efficacy
Q39139171Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens.
Q35836695Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
Q53845870Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Q33899677Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier function
Q35156930Epigenetic control of intestinal barrier function and inflammation in zebrafish
Q58580902Epigenetics, DNA Organization, and Inflammatory Bowel Disease
Q33556277Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation
Q47795925Epithelial Organization: The Gut and Beyond
Q33782512Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
Q82215769Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
Q34014510Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
Q92237386Escherichia coli Nissle 1917 Protects Intestinal Barrier Function by Inhibiting NF-κB-Mediated Activation of the MLCK-P-MLC Signaling Pathway
Q36741674Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol
Q38118340Ethanol metabolism and its effects on the intestinal epithelial barrier
Q88142508Evolving insights in the pathophysiology of complications of cirrhosis: The farnesoid X receptor (FXR) to the rescue?
Q34978849Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction
Q35649797Fast disease progression in simian HIV-infected female macaque is accompanied by a robust local inflammatory innate immune and microbial response
Q37080684Fetal cholinergic anti-inflammatory pathway and necrotizing enterocolitis: the brain-gut connection begins in utero
Q37393706FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation
Q39376100From clinical uncertainties to precision medicine: the emerging role of the gut barrier and microbiome in small bowel functional diseases
Q34420883From intestinal permeability to dysmotility: the biobreeding rat as a model for functional gastrointestinal disorders
Q39877230GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability
Q34520959Gastrointestinal mucosal barrier function and diseases.
Q35847556Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses
Q45743243Glucocorticoids regulate barrier function and claudin expression in intestinal epithelial cells via MKP-1.
Q37559869Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression
Q64229900Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Q37808740Gut permeability and food allergies
Q39102508Gut permeability and mucosal inflammation: bad, good or context dependent.
Q42207253HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.
Q30665173Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
Q36618950Higher expression of phosphorylated myosin regulatory light chain in the common bile duct in pancreaticobiliary maljunction accompanied by bile duct dilatation in children: a post-mortem observational study
Q36363577How stress induces intestinal hypersensitivity
Q39277299Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function
Q40270359IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1.
Q35215366IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
Q37047096IL-1beta causes an increase in intestinal epithelial tight junction permeability
Q34254423IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
Q64259788Identification of Serum Biomarkers for Intestinal Integrity in a Broiler Chicken Malabsorption Model
Q92738445Impaired intestinal barrier function in a mouse model of hyperuricemia
Q58588861In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability
Q36522913In Vivo and In Vitro Antinociceptive Effect of Fagopyrum cymosum (Trev.) Meisn Extracts: A Possible Action by Recovering Intestinal Barrier Dysfunction
Q38902578Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
Q42288030Inflammatory bowel disease therapies and gut function in a colitis mouse model.
Q35761217Inflammatory bowel disease: is it really just another break in the wall?
Q46592696Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Q36309506Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury
Q37045757Innate and adaptive mechanisms to control [corrected] pathological intestinal inflammation
Q37578039Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis
Q37594928Interferon-Alpha Promotes Th1 Response and Epithelial Apoptosis via Inflammasome Activation in Human Intestinal Mucosa
Q33808592Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways
Q39592093Interferon-γ-induced increases in intestinal epithelial macromolecular permeability requires the Src kinase Fyn.
Q39853564Interleukin-1β Mediates β-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells
Q38417912Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
Q89886066Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development
Q92356819Intestinal barrier dysfunction in severe burn injury
Q38584691Intestinal epithelial barrier function and tight junction proteins with heat and exercise
Q58556455Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis
Q35953647Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.
Q29618086Intestinal mucosal barrier function in health and disease
Q26859272Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases
Q92767987Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
Q38117175Investigational cytokine-targeted therapies for ulcerative colitis.
Q39562918Involvement of HIF-1α in MLCK-dependent endothelial barrier dysfunction in hypoxia
Q37591476Irinotecan disrupts tight junction proteins within the gut : implications for chemotherapy-induced gut toxicity.
Q37914788Is metabolic stress a common denominator in inflammatory bowel disease?
Q38199343JAM-related proteins in mucosal homeostasis and inflammation
Q36854925JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function
Q37259782LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.
Q36071733Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2
Q28568715Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
Q33816018Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
Q47413203Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis
Q47313771MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells.
Q38301696MMPs contribute to TNF-alpha-induced alteration of the blood-cerebrospinal fluid barrier in vitro
Q24317362Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability
Q37047106Mechanism of cytokine modulation of epithelial tight junction barrier
Q37047083Mechanism of glucocorticoid regulation of the intestinal tight junction barrier
Q37629444Mechanisms and functional implications of intestinal barrier defects
Q37594944Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli.
Q26774688Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection
Q38099727Mechanisms of action of anti-tumor necrosis factor α agents in Crohn's disease
Q34464682Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
Q58774497Mechanisms regulating intestinal barrier integrity and its pathological implications
Q64103290Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation
Q28077783Metabiotics: One Step ahead of Probiotics; an Insight into Mechanisms Involved in Anticancerous Effect in Colorectal Cancer
Q28555167Metformin Improves Ileal Epithelial Barrier Function in Interleukin-10 Deficient Mice
Q41483056Modulation by thyroid hormone of myosin light chain phosphorylation and aquaporin 5 protein expression in intact lung.
Q36421582Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen
Q34789106Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous system
Q52609696Molecular Pathophysiology of Epithelial Barrier Dysfunction in Inflammatory Bowel Diseases.
Q35984123Molecular and cellular mechanisms of food allergy and food tolerance.
Q26864785Molecular aspects of tight junction barrier function
Q35569905Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application
Q38953543Molecular pathways driving disease-specific alterations of intestinal epithelial cells
Q36439020Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants
Q38293774Mucosal healing in the era of biologic agents in treatment of inflammatory bowel disease
Q38810529Mucosal pathobiology and molecular signature of epithelial barrier dysfunction in the small intestine in irritable bowel syndrome.
Q34110996Multiple facets of intestinal permeability and epithelial handling of dietary antigens
Q41982611Murine guanylate cyclase C regulates colonic injury and inflammation
Q52647636Mycophenolic acid mediated disruption of the intestinal epithelial tight junctions.
Q35092790Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis
Q46830240Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro.
Q43474062Myosin light chain kinase inhibitor inhibits dextran sulfate sodium-induced colitis in mice
Q35085249Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats.
Q31057409Myosin light chain kinase mediates intestinal barrier disruption following burn injury
Q38739653Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury.
Q36062835Myosin light chain kinase: pulling the strings of epithelial tight junction function
Q80809479NF-kappaB p50 and p65 subunits control intestinal homeostasis
Q38683067Natural Nuclear Factor Kappa Beta Inhibitors: Safe Therapeutic Options for Inflammatory Bowel Disease
Q35664929Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses
Q42082089No static at all.
Q90168292Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis
Q99593443Non-lethal Plasmodium yoelii infection drives complex patterns of Th2-type host immunity and mast cell-dependent bacteremia
Q42811392Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migration
Q37197950Novel mechanism of cytokine-induced disruption of epithelial barriers: Janus kinase and protein kinase D-dependent downregulation of junction protein expression
Q47221249Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development
Q30009590Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux
Q34918139Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
Q36323908Olive oil bioactives protect pigs against experimentally-induced chronic inflammation independently of alterations in gut microbiota
Q26738728Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
Q51614351Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition.
Q55245208Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models.
Q64058580Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
Q85948686Osteoprotegerin exerts its pro-inflammatory effects through nuclear factor-κB activation
Q28507355Overexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in mice
Q35235187Oxymatrine improves intestinal epithelial barrier function involving NF-κB-mediated signaling pathway in CCl4-induced cirrhotic rats
Q42471534Paracellular permeability is increased by basal lipopolysaccharide in a primary culture of colonic epithelial cells; an effect prevented by an activator of Toll-like receptor-2.
Q35689533Pathogenic potential of Campylobacter ureolyticus
Q36943034Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall
Q36996000Plasma and mucosal HIV viral loads are associated with genital tract inflammation in HIV-infected women
Q38211365Pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation
Q39578562Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation
Q89685652Presence of Inflammatory Group I and III Innate Lymphoid Cells in the Colon of SIV-infected Rhesus Macaques
Q33309955Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Q30425823Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism
Q37387991Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression
Q34166824Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins
Q46889906Proinflammatory effect of trivalent arsenical species in a co-culture of Caco-2 cells and peripheral blood mononuclear cells
Q42877924Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD.
Q37994635Proteases and the gut barrier.
Q37396622Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications
Q38265533Protein kinases are potential targets to treat inflammatory bowel disease
Q41378914Pseudomonas fluorescens alters the intestinal barrier function by modulating IL-1β expression through hematopoietic NOD2 signaling.
Q28078842Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals
Q50922715Real-time monitoring of trans-epithelial electrical resistance in cultured intestinal epithelial cells: the barrier protection of water-soluble dietary fiber.
Q39336319Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
Q34287155Regulation of intestinal epithelial permeability by tight junctions.
Q33491056Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: a novel model for studying the pathomechanisms of inflammatory bowel disease cytokines
Q28246127Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues
Q38141920Regulation of paracellular permeability: factors and mechanisms.
Q90705632Regulation of the intestinal barrier by nutrients: The role of tight junctions
Q36291601Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction.
Q33559181Role of myosin light chain kinase in intestinal epithelial barrier defects in a rat model of bowel obstruction
Q37026888Role of non-muscle myosin light chain kinase in neutrophil-mediated intestinal barrier dysfunction during thermal injury
Q37058869Role of the intestinal barrier in inflammatory bowel disease
Q37028447Secreted Listeria adhesion protein (Lap) influences Lap-mediated Listeria monocytogenes paracellular translocation through epithelial barrier
Q36483860Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon
Q55517489Severe Burn-Induced Intestinal Epithelial Barrier Dysfunction Is Associated With Endoplasmic Reticulum Stress and Autophagy in Mice.
Q41588684Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine
Q38696638Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
Q37289295Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function.
Q36642527Stimulus-induced reorganization of tight junction structure: the role of membrane traffic
Q38180279Stromal regulation of embryonic and postnatal mammary epithelial development and differentiation
Q38718585TGF-β1 protects intestinal integrity and influences Smads and MAPK signal pathways in IPEC-J2 after TNF-α challenge
Q35043980TGFβs modulate permeability of the blood-epididymis barrier in an in vitro model
Q27015742TLR4/PKC-mediated tight junction modulation: a clinical marker of chemotherapy-induced gut toxicity?
Q37636048The Effect of Oral Intake of Low-Temperature-Processed Whey Protein Concentrate on Colitis and Gene Expression Profiles in Mice.
Q39406091The N-terminal fragment of chromogranin A, vasostatin-1 protects mice from acute or chronic colitis upon oral administration.
Q33842314The altered tight junctions: an important gateway of bacterial translocation in cachexia patients with advanced gastric cancer
Q91722641The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation
Q40216858The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response
Q39398254The intestinal barrier: a fundamental role in health and disease
Q39009998The intestinal epithelial barrier: a therapeutic target?
Q36310293The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease
Q91241929The many faces of tumor necrosis factor signaling in the intestinal epithelium
Q90499640The mechanobiology of tight junctions
Q57291610The microbiome and HLA-B27-associated acute anterior uveitis
Q34617424The role of molecular remodeling in differential regulation of tight junction permeability
Q33505862The roles of tumor necrosis factor-alpha in colon tight junction protein expression and intestinal mucosa structure in a mouse model of acute liver failure
Q38753779The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction
Q28289667The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease
Q41545568The squid ink polysaccharides protect tight junctions and adherens junctions from chemotherapeutic injury in the small intestinal epithelium of mice
Q37457219The tight junction in inflammatory disease: communication breakdown
Q36305755Tight Junction Pore and Leak Pathways: A Dynamic Duo
Q40864710Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.
Q38189138Tight junctions and IBS--the link between epithelial permeability, low-grade inflammation, and symptom generation?
Q36950607Tight junctions on the move: molecular mechanisms for epithelial barrier regulation
Q89744172Total Flavonoid Extract from Hawthorn (Crataegus pinnatifida) Improves Inflammatory Cytokines-Evoked Epithelial Barrier Deficit
Q90296333Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway
Q54401840Transplantation of human umbilical mesenchymal stem cells attenuates dextran sulfate sodium-induced colitis in mice.
Q38671207Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis.
Q50554366Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells.
Q36285773Tumor necrosis factor alpha increases intestinal permeability in mice with fulminant hepatic failure
Q50920142Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition.
Q53835631Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enabling enhanced intestinal barrier function.
Q41415165Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling.
Q48350421Yogurt inhibits intestinal barrier dysfunction in Caco-2 cells by increasing tight junctions
Q30157199ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton

Search more.