Claudin-2 regulates colorectal inflammation via myosin light chain kinase-dependent signaling.

scientific article published on 11 January 2013

Claudin-2 regulates colorectal inflammation via myosin light chain kinase-dependent signaling. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10620-012-2535-3
P698PubMed publication ID23306855

P50authorMikio FuruseQ59694378
P2093author name stringTakeshi Azuma
Masaru Yoshida
Shin Nishiumi
Masayuki Nishida
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Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout miceQ42872490
MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent mannerQ44160668
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Matrix metalloproteinase levels are elevated in inflammatory bowel diseaseQ61758671
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Autocrine actions of matrix metalloproteinase (MMP)-2 counter the effects of MMP-9 to promote survival and prevent terminal differentiation of cultured human keratinocytesQ81320671
Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cellsQ84757783
Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small IntestineQ84779796
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expressionQ24536188
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Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cellsQ28214827
Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoterQ28251485
Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubulesQ28279525
Claudin-2, a component of the tight junction, forms a paracellular water channelQ28282138
Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cellsQ28284028
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestineQ28509306
p38 MAP-kinases pathway regulation, function and role in human diseasesQ29616303
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's diseaseQ33249005
Cell adhesion, polarity, and epithelia in the dawn of metazoans.Q33340425
TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signalingQ33408865
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivityQ33782512
Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel diseaseQ33964919
Claudins in occluding junctions of humans and fliesQ33994147
Epithelial barriers, compartmentation, and cancerQ35634246
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cellsQ36316586
Occludin is a functional component of the tight junction.Q36828867
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformationQ36982054
Inflammatory bowel disease, past, present and future: lessons from animal modelsQ37093634
Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestineQ37246271
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.Q37266104
Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activityQ37398298
Structure-function studies of claudin extracellular domains by cysteine-scanning mutagenesis.Q37431293
Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrierQ37580772
Therapeutic options to modulate barrier defects in inflammatory bowel diseaseQ37629447
P433issue6
P921main subjectinflammationQ101991
P304page(s)1546-1559
P577publication date2013-01-11
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleClaudin-2 regulates colorectal inflammation via myosin light chain kinase-dependent signaling
P478volume58

Reverse relations

cites work (P2860)
Q47969652Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer.
Q26861369Conceptual barriers to understanding physical barriers
Q33765538Emerging multifunctional roles of Claudin tight junction proteins in bone
Q54370105Epithelial MLCK and smooth muscle MLCK may play different roles in the development of inflammatory bowel disease.
Q39102508Gut permeability and mucosal inflammation: bad, good or context dependent.
Q40171045IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance
Q36382104Increased urothelial paracellular transport promotes cystitis
Q38902578Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
Q37327571Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules
Q26741215Pancreatic cancer stem cell markers and exosomes - the incentive push
Q36245729Sijunzi Decoction attenuates 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats and ameliorates TNBS-induced claudin-2 damage via NF-κB pathway in Caco2 cells
Q34457032Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis.
Q41460133Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions

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