Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

scientific article

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI992
P3181OpenCitations bibliographic resource ID1386989
P932PMC publication ID508669
P698PubMed publication ID9486988
P5875ResearchGate publication ID13744659

P2093author name stringG Adler
R M Schmid
S Liptay
C Wahl
P2860cites workCloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65Q24309237
Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3)Q24321796
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1Q24564855
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activationQ28776205
Inhibition of NF-kappa B by sodium salicylate and aspirinQ29614708
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylationQ29614709
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
NF-kappa B: ten years afterQ29618566
Structure, regulation and function of NF-kappa BQ29620225
Inhibition of leucocyte motility by drugs used in ulcerative colitisQ34496132
Autoregulation of I kappa B alpha activityQ34879939
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.Q35066218
Sulfasalazine. Multiplicity of actionQ35255496
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cellsQ36231310
Comparative analysis of systemic immunological parameters in ulcerative colitis and idiopathic proctitis: effects of sulfasalazine in vivo and in vitroQ39221754
An experiment to determine the active therapeutic moiety of sulphasalazineQ39458926
Pharmacological and biochemical actions of sulphasalazineQ39460815
Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alphaQ40401245
Sulphasalazine, sulphapyridine or 5-aminosalicylic acid--which is the active moiety in rheumatoid arthritis?Q40931381
Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.Q41207958
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesisQ41283113
Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoidsQ41283123
Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide.Q41499725
Biochemical and morphological differentiation of the human colonic epithelial cell line SW620 in the presence of dimethylsulfoxideQ41637579
The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatientsQ41839631
Inhibition of proliferative responses and interleukin 2 productions by salazosulfapyridine and its metabolitesQ44066704
Inhibition of antibody secretion by 5-aminosalicylic acid.Q52117669
The prophylactic effect of salazosulphapyridine in ulcerative colitis during long-term treatment. A double-blind trial on patients asymptomatic for one year.Q53833973
Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generationQ68290791
Distribution studies of salicylazosulfapyridine and its metabolitesQ68772098
Inhibitory effects of sulfasalazine and related compounds on superoxide production by human polymorphonuclear leukocytesQ69375877
5-Aminosalicylic acid or sulphapyridine. Which is the active moiety of sulphasalazine in rheumatoid arthritis?Q69890086
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?Q69908719
Effect of sulphasalazine and its metabolites on mitogen induced transformation of lymphocytes--clues to its clinical action?Q69925644
The effect of sodium salicylate and aspirin on NF-kappa BQ70815330
Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigrationQ71059480
IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytesQ71217174
Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in miceQ71472065
Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic acid in the treatment of ulcerative colitisQ72212041
Structural and functional analysis of NF-kappa B. Determinants of DNA binding specificity and protein interactionQ72352149
Therapeutic Efficacy of Sulfasalazine and Its Metabolites in Patients with Ulcerative Colitis and Crohn's DiseaseQ72437063
I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa BQ72571349
The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa BQ73909444
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectsulfasalazineQ420035
P304page(s)1163-74
P577publication date1998-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleSulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
P478volume101

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cites work (P2860)
Q4054500815-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity
Q4044126817beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization
Q437443335-Aminosalicylate stimulates phospholipase D activity in macrophages.
Q338762685-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats
Q803377355-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats
Q360023695-aminosalicylic acid is an attractive candidate agent for chemoprevention of colon cancer in patients with inflammatory bowel disease
Q58699124A Low Frequency of IL-17-Producing CD8 T-Cells Is Associated With Persistent Immune Activation in People Living With HIV Despite HAART-Induced Viral Suppression
Q40343429A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival
Q25257862A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].
Q50547970A photoactivatable marker protein for pulse-chase imaging with superresolution.
Q30445818A role for the canonical nuclear factor-κB pathway in coupling neurotrophin-induced differential survival of developing spiral ganglion neurons
Q34178953A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.
Q46439316Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis
Q28394186Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs
Q41856268Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF
Q35354271Activation of nuclear factor kappaB as a target for anti-inflammatory therapy
Q41059656Activation of the transcription factor NF-kappaB by retrieval is required for long-term memory reconsolidation.
Q28551369Addition of Berberine to 5-Aminosalicylic Acid for Treatment of Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice
Q35679235Agents Which Inhibit NF-κB Signaling Block Spontaneous Contractile Activity and Negatively Influence Survival of Developing Myotubes
Q52537292Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells.
Q33268281An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm
Q30349885Anti-human immunodeficiency virus type 1 microbicide cellulose acetate 1,2-benzenedicarboxylate in a human in vitro model of vaginal inflammation.
Q38332948Anti-inflammatory effect of pelubiprofen, 2-[4-(oxocyclohexylidenemethyl)-phenyl]propionic acid, mediated by dual suppression of COX activity and LPS-induced inflammatory gene expression via NF-κB inactivation
Q39677660Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats
Q37927081Anti-inflammatory mediators as physiological and pharmacological regulators of parturition.
Q44786816Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice
Q46147603Antifibrotic effect of meloxicam in rat liver: role of nuclear factor kappa B, proinflammatory cytokines, and oxidative stress.
Q37071320Antiinfective agents affecting cognition: a review
Q37096512Application of prodrugs to inflammatory diseases of the gut.
Q33708645Arsenic Trioxide Induces Apoptosis of Fibroblast-like Synoviocytes and Represents Antiarthritis Effect in Experimental Model of Rheumatoid Arthritis
Q27860821Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Q38323803Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy
Q43749577Butyrate inhibits interleukin-1-mediated nuclear factor-kappa B activation in human epithelial cells
Q44272936Butyrate modulates intestinal epithelial cell-mediated neutrophil migration
Q40715072Calcineurin inhibitors, cyclosporin A and tacrolimus inhibit expression of inducible nitric oxide synthase in colon epithelial and macrophage cell lines.
Q47844226Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation
Q26738536Cancer-associated fibroblasts in hepatocellular carcinoma
Q45096825Catalposide, a compound isolated from catalpa ovata, attenuates induction of intestinal epithelial proinflammatory gene expression and reduces the severity of trinitrobenzene sulfonic Acid-induced colitis in mice
Q35357667Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn's disease
Q34079481Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
Q30415505Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering
Q34437388Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism
Q42360841Clinical course and prognosis in ulcerative colitis: results from population-based and observational studies
Q34025193Clinical pharmacokinetics of slow release mesalazine
Q39556601Cocoplum (Chrysobalanus icaco L.) anthocyanins exert anti-inflammatory activity in human colon cancer and non-malignant colon cells
Q37290683Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells.
Q90701307Combination Immunotherapy with Passive Antibody and Sulfasalazine Accelerates Fungal Clearance and Promotes the Resolution of Pneumocystis-Associated Immunopathogenesis
Q47852580Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response.
Q34086102Comparative tolerability of treatments for inflammatory bowel disease
Q42910062Comparison of Prostaglandin E2 Receptor Subtype 4 Agonist and Sulfasalazine in Mouse Colitis Prevention and Treatment
Q57283082Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course
Q37095261Conditional knockout of polarity complex (atypical) PKCι reveals an anti-inflammatory function mediated by NF-κB.
Q30318026Conventional basis therapy of rheumatoid arthritis. Effects within and outside cells
Q44361949Curcumin attenuates DNB-induced murine colitis.
Q38133655Current immunotherapy in rheumatoid arthritis
Q34192660Current management of inflammatory bowel disease and colorectal cancer
Q92977405Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
Q36622124Current therapy of inflammatory bowel disease in children
Q64095457Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
Q44368516Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model
Q41682361Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs
Q28394197Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha
Q38363570Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.
Q44066867Different modes of NF-kappaB/Rel activation in pancreatic lobules
Q31394204Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats
Q40725019Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.
Q33797156Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway
Q24298825Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter
Q38645738Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics.
Q80388037Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor necrosis factor-alpha
Q40672859Dual role of the NF-kappaB transcription factor in the death of immature neurons.
Q33511367Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
Q28346425Effect of 4-trifluoromethyl derivatives of salicylate on nuclear factor kappaB-dependent transcription in human astrocytoma cells
Q39814847Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver
Q24812982Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells
Q36784552Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease.
Q28564809Effect of sulfasalazine on renal ischemia/reperfusion injury in rats
Q90435719Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages
Q37667524Effects of sulfasalazine on lipid peroxidation and histologic liver damage in a rat model of obstructive jaundice and obstructive jaundice with lipopolysaccharide-induced sepsis
Q43804970Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis
Q46319705Efficacy of sulphasalazine on lung histopathology in a murine model of chronic asthma
Q35916725Emu oil offers protection in Crohn's disease model in rats
Q46621544Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2).
Q46410934Epidermal growth factor activates nuclear factor-kappaB in human proximal tubule cells
Q40688539Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells.
Q40714025Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate
Q43539821Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells
Q73154113Failure to activate NF-kappaB promotes apoptosis of retinal ganglion cells following optic nerve transection
Q40274111Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines
Q39094882Fucosylated multiwalled carbon nanotubes for Kupffer cells targeting for the treatment of cytokine-induced liver damage
Q38348120Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
Q43687794Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium.
Q40530967Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB.
Q51112994Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques.
Q43687369Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel disease therapy
Q40684555Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway
Q36903569Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models
Q37734905Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice
Q49601734Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis.
Q28547125High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
Q83155183Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats
Q99411709Identification of Target Genes Related to Sulfasalazine in Triple-Negative Breast Cancer Through Network Pharmacology
Q33893095Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling
Q91827723Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
Q37929578Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia
Q33680480Immune Modulation with Sulfasalazine Attenuates Immunopathogenesis but Enhances Macrophage-Mediated Fungal Clearance during Pneumocystis Pneumonia
Q91054766Immunopharmacological effect of β-d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients
Q37165528Improving delivery of aminosalicylates in ulcerative colitis: effect on patient outcomes
Q73082491Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice
Q33868970Indications for 5-aminosalicylate in inflammatory bowel disease: is the body of evidence complete?
Q43289279Induction of RIP-2 kinase by proinflammatory cytokines is mediated via NF-kappaB signaling pathways and involves a novel feed-forward regulatory mechanism
Q35596974Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease.
Q39741341Induction of laryngeal cancer cell death by Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid.
Q55057352Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study.
Q38017873Inflammatory bowel disease and pregnancy: overlapping pathways
Q42503199Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
Q35815842Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination
Q43551315Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis
Q40911348Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine
Q33872837Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo
Q44462694Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis
Q37907354Inhibitory kappa B Kinases as targets for pharmacological regulation
Q24536188Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
Q44409656Interferon‐γ induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis
Q35748847Interleukin-10 inhibits elevated chemokine interleukin-8 and regulated on activation normal T cell expressed and secreted production in cystic fibrosis bronchial epithelial cells by targeting the I(k)B kinase alpha/beta complex
Q35825309Interplaying factors that effect multiple sclerosis causation and sustenance
Q28184300Involvement of nuclear factor-kappa B (NF-kappaB) activation in mitogen-induced lymphocyte proliferation: inhibitory effects of lymphoproliferation by salicylates acting as NF-kappaB inhibitors
Q92571509Ischemia-Reperfusion Injury in Sickle Cell Disease: From Basics to Therapeutics
Q36561514LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease
Q54941896MUC13 contributes to rewiring of glucose metabolism in pancreatic cancer.
Q39697425Macrophages express membrane bound form of APRIL that can generate immunomodulatory signals
Q38580123Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission
Q36577542Mechanisms of disease: Transcription factors in inflammatory arthritis
Q38220667Mechanisms of testicular torsion and potential protective agents
Q34161820Medical therapy for Crohn's disease: the state of the art.
Q33662010Medical therapy for inflammatory bowel disease
Q34745582Medical therapy for ulcerative colitis
Q30638019Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes
Q34027828Mesalamine for prophylaxis of small bowel Crohn's disease recurrence
Q40780519Mesalamine induces manganese superoxide dismutase in rat intestinal epithelial cell lines and in vivo
Q40373048Mesalamine promotes intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism
Q90265833Mice Deficient in Epithelial or Myeloid Cell Iκκβ Have Distinct Colonic Microbiomes and Increased Resistance to Citrobacter rodentium Infection
Q91062672Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Q42562683Mirror, mirror on the wall: which microbiomes will help heal them all?
Q34999557Miscellaneous treatments, I: sulfasalazine and pentoxifylline: unapproved uses, dosages, or indications
Q38644746Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity.
Q35044669Molecular mechanisms of sulfasalazine-induced T-cell apoptosis
Q36709532NF-kappa B as a target for cancer therapy
Q36709522NF-kappa B as a therapeutic target in autoimmune disease.
Q40814092NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells
Q44053478NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival.
Q43753204NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci
Q29614603NF-kappaB in cancer: from innocent bystander to major culprit
Q81768343NF-kappaB in carcinoma therapy and prevention
Q37302741NF-kappaB signaling, liver disease and hepatoprotective agents
Q24303059NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
Q44559483NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells
Q77917939NF-kappaB/Rel activation in cerulein pancreatitis
Q35079912NF-kappaB/Rel transcriptional pathway: implications in pancreatic cancer
Q33930920NF-kappaB/rel/IkappaB: implications in gastrointestinal diseases
Q39142554NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases
Q42717979NF-κB subunits are differentially distributed in cells of lumbar dorsal root ganglia in naïve and diabetic rats
Q37580226NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man.
Q54399200Nod2 mutation enhances NF-kappa B activity and bacterial killing activity of macrophages.
Q35761406Non-viral delivery of nuclear factor-kappaB decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis
Q44020836Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells
Q33761124Nuclear factor-kappa B (NFkappaB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease
Q28344806Nuclear factor-kappa B activation in human testicular apoptosis
Q46086621Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers
Q37958061Nuclear factor-kappa B inhibitors; a patent review (2006-2010).
Q36085634Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
Q48475079Opposite in vivo effects of agents that stimulate or inhibit the glutamate/cysteine exchanger system xc- on the inhibition of hippocampal LTP by Aß.
Q44137073Osmotic stress sensitizes naturally resistant cells to TNF-alpha-induced apoptosis
Q38078000Oxidative stress and cancer pain.
Q37827164Oxidative stress as a mechanism underlying sulfasalazine-induced toxicity.
Q38289025Oxygen-evoked changes in transcriptional activity of the 5'-flanking region of the human amiloride-sensitive sodium channel (alphaENaC) gene: role of nuclear factor kappaB.
Q36483981Pathophysiology and treatment of stroke in sickle-cell disease: present and future
Q34162399Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
Q42414904Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus
Q48899356Pharmacogenomics of NAT2 and ABCG2 influence the toxicity and efficacy of sulphasalazine containing DMARD regimens in early rheumatoid arthritis.
Q44324305Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model
Q39016673Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness
Q78353195Phosphatase inhibition leads to activation of IkappaB kinase in murine macrophages
Q35048399Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell
Q40977170Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB.
Q33768874Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells
Q36633307Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis
Q34067424Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory
Q77921896Protein kinase C-dependent activation of NF-kappaB in enterocytes is independent of IkappaB degradation
Q45408799Raf-1 and protein kinase B regulate cell survival through the activation of NF-kappaB in hepatitis B virus X-expressing cells
Q33795121Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models.
Q36403180Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase
Q36274222Redox-dependent impairment of vascular function in sickle cell disease
Q42521488Regulation and function of COX-2 gene expression in isolated gastric parietal cells
Q35609369Regulation of nuclear factor-kappaB in intestinal epithelial cells in a cell model of inflammation
Q37740553Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences
Q38631567Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium
Q39785651Reverse signaling through BAFF differentially regulates the expression of inflammatory mediators and cytoskeletal movements in THP-1 cells
Q28480639Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats
Q34637311Role of nuclear factor kappaB in synovial inflammation
Q37208648Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.
Q49357731Screening a small molecule library to identify inhibitors of NF-κB inducing kinase and pro-labor genes in human placenta
Q24683212Secretion of interleukin-8 by human-derived cell lines infected with Mycobacterium bovis
Q24681818Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)
Q34116362Series introduction: the transcription factor NF-kappaB and human disease
Q36546794Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome
Q33598827Signal transduction and transcription factors in rheumatic disease
Q90059434Statin administration activates system xC- in skeletal muscle: a potential mechanism explaining statin-induced muscle pain
Q39620643Stimulation of FasL induces production of proinflammatory mediators through activation of mitogen-activated protein kinases and nuclear factor-κB in THP-1 cells
Q36512479Sulfasalazine Treatment Suppresses the Formation of HLA-B27 Heavy Chain Homodimer in Patients with Ankylosing Spondylitis
Q50449062Sulfasalazine and its metabolites inhibit platelet function in patients with inflammatory arthritis.
Q90079320Sulfasalazine as an Immunomodulator of the Inflammatory Process during HIV-1 Infection
Q40987201Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes.
Q36906408Sulfasalazine blocks the development of tactile allodynia in diabetic rats
Q41667251Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema
Q39783099Sulfasalazine induces apoptosis of HBx-expressing cells in an NF-kappaB-independent manner
Q45962157Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia.
Q36951489Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury
Q41707939Sulfasalazine inhibits reperfusion injury and prolongs allograft survival in rat cardiac transplants
Q34543666Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB.
Q78197550Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages
Q40345193Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers
Q51767031Sulfasalazine reduces inflammatory renal injury in unilateral ureteral obstruction.
Q64099971Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction
Q40176569Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis
Q43756729Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug
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