ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway

scientific article published on 23 March 2016

ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E15-08-0598
P932PMC publication ID4865316
P698PubMed publication ID27009203

P50authorCarla AnguloQ95987987
Antonia Avila-floresQ42837498
Esther Lopez-BayghenQ43288822
P2093author name stringPablo Bautista-García
Lorenza González-Mariscal
Arturo Ponce
José Segovia
Alaide Domínguez-Calderón
Bibiana Chávez-Munguía
José-Víctor Calderón-Salinas
José Luis Reyes
Helios Gallego-Gutiérrez
Lourdes Alarcón
Dolores Martín-Tapia
Leticia Ramírez
P2860cites workInactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt responseQ24299975
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mTOR signaling in growth control and diseaseQ24634174
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3Q28138745
Tight junction proteinsQ28217124
Phosphorus assay in column chromatographyQ29614973
Role of YAP/TAZ in mechanotransductionQ29615411
ZO proteins and redox-dependent processes.Q30155864
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonQ30157199
Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51.Q30477623
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosisQ33292546
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Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-betaQ33902166
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Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.Q34191705
Signaling mechanisms of the epithelial-mesenchymal transitionQ35213019
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epitheliaQ35756679
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophyQ35787211
The molecular architecture of human DicerQ35871761
Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanismQ78351814
An image analysis method for the precise selection and quantitation of fluorescently labeled cellular constituents: application to the measurement of human muscle cells in cultureQ36085629
Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy.Q36235333
Organ size control by Hippo and TOR pathways.Q36696631
Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle.Q37078622
The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257.Q37098759
Hippo pathway effector Yap promotes cardiac regenerationQ37117699
Factors controlling intracellular protein turnover in the kidney.Q37988644
The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathwayQ38015671
Cellular events in renal hypertrophyQ38201489
YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29Q39246531
Identification of claudins by western blot and immunofluorescence in different cell lines and tissuesQ39515546
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signallingQ39651925
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.Q40024709
Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription factor c-Myc.Q40078195
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architectureQ40156403
Functional correlates of compensatory renal hypertrophyQ40349860
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.Q40456155
Progression of renal disease and renal hypertrophyQ40543219
The tight junction protein ZO-2 associates with Jun, Fos and C/EBP transcription factors in epithelial cells.Q40599754
TGF-beta1-mediated hypertrophy involves inhibiting pRB phosphorylation by blocking activation of cyclin E kinaseQ40935957
Messenger RNA in compensatory renal hypertrophyQ41203747
Influence of ammonia and pH on protein and amino acid metabolism in LLC-PK1 cellsQ41605515
Role of calcium in tight junction formation between epithelial cellsQ41712997
Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.Q42159137
β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesisQ42421566
S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophyQ42454439
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.Q43166689
Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1.Q44465887
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Q45345068
A new triterpenoid saponin from Artemisia sphaerocephalaQ46196716
Role of mammalian target of rapamycin signaling in compensatory renal hypertrophyQ46402341
Drosophila S6 kinase: a regulator of cell sizeQ47072437
Acidosis and weight loss are induced by cyclosporin A in uninephrectomized rats.Q47246451
Hippo-YAP and mTOR pathways collaborate to regulate organ sizeQ47269619
The tight junction protein ZO-2 blocks cell cycle progression and inhibits cyclin D1 expression.Q53388593
Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules.Q54049050
Characterization of a novel Dp71 dystrophin-associated protein complex (DAPC) present in the nucleus of HeLa cells: Members of the nuclear DAPC associate with the nuclear matrixQ60708115
Influence of age on compensatory renal growth in ratsQ69499083
Evidence for a pathogenic linkage between glomerular hypertrophy and sclerosisQ70174111
Gene expression during liver regenerationQ70679154
Role of lysosomal cathepsin activities in cell hypertrophy induced by NH4Cl in cultured renal proximal tubule cellsQ71534397
Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubuleQ74599385
The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27Q77963948
P4510describes a project that usesImageJQ1659584
P433issue10
P304page(s)1581-1595
P577publication date2016-03-23
P1433published inMolecular Biology of the CellQ2338259
P1476titleZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway
P478volume27

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cites work (P2860)
Q91668285Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice
Q39363466Cell Junctions in Hippo Signaling
Q44912536Cell-Cell Junctions Organize Structural and Signaling Networks
Q92733192Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network
Q39371274Cross talk between the Crumbs complex and Hippo signaling in renal epithelial cells.
Q43651454Dual roles of yes-associated protein (YAP) in colorectal cancer
Q39412884SUMOylation regulates the intracellular fate of ZO-2.
Q38879992Tight junctions: from simple barriers to multifunctional molecular gates
Q92874332ZO-2 Is a Master Regulator of Gene Expression, Cell Proliferation, Cytoarchitecture, and Cell Size
Q39246229ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation.

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