ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation

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ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.201404140
P932PMC publication ID4362456
P698PubMed publication ID25753039

P50authorKarl MatterQ43165892
Maria S. BaldaQ55117896
Neil DuftonQ58876559
P2093author name stringMartin A Schwartz
Daniel E Conway
Anna M Randi
Minghao Chia
Lourdes Osuna Almagro
Olga Tornavaca
P2860cites workJunctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1Q22254323
Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin familyQ24293163
Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growthQ24306682
Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survivalQ24338583
Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpAQ24548016
A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cellsQ24598525
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complexQ24603370
Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasionQ27334502
The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1Q27675242
Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludinQ28139702
Size-selective loosening of the blood-brain barrier in claudin-5-deficient miceQ28203769
JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulinQ28591650
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytesQ28592273
Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherinQ28771711
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamicsQ29615714
Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cellsQ30157022
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeletonQ30157199
Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1.Q30412646
p21-activated kinase regulates endothelial permeability through modulation of contractility.Q30434340
Dynamic molecular processes mediate cellular mechanotransductionQ30453937
ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherensQ30483283
alpha-Catenin as a tension transducer that induces adherens junction developmentQ33572769
A mechanism of mechanotransduction at the cell-cell interface: emergence of α-catenin as the center of a force-balancing mechanism for morphogenesis in multicellular organismsQ33986346
Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complexQ34279275
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epitheliaQ35756679
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodelingQ35839771
Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signalingQ36056399
Activity of Rho-family GTPases during cell division as visualized with FRET-based probesQ36323206
Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeabilityQ36324231
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.Q36559702
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cellsQ36678082
The role of junctional adhesion molecules in vascular inflammationQ36831671
Putting the brakes on cancer cell migration: JAM-A restrains integrin activationQ37079390
Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migrationQ37146658
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctionsQ37524262
Pathobiology of junctional adhesion moleculesQ37831307
Adhesion molecule signalling: not always a sticky business.Q37846527
Lessons from the endothelial junctional mechanosensory complex.Q37975196
Endothelial cell-to-cell junctions: adhesion and signaling in physiology and pathologyQ38048760
Cytoprotective signaling and gene expression in endothelial cells and macrophages-lessons for atherosclerosisQ38057357
Mechanosensitive systems at the cadherin-F-actin interfaceQ38092619
The role of tight junctions in cancer metastasisQ38252726
Tetraspanin CD9 links junctional adhesion molecule-A to αvβ3 integrin to mediate basic fibroblast growth factor-specific angiogenic signalingQ39311689
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesisQ39604115
Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma.Q39878729
Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells.Q40665549
Angiogenic synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in an in vitro quantitative microcarrier-based three-dimensional fibrin angiogenesis systemQ41812238
Microtubules containing detyrosinated tubulin are less dynamicQ42054726
A novel, microcarrier-based in vitro assay for rapid and reliable quantification of three-dimensional cell migration and angiogenesisQ70957426
Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient miceQ79816024
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
PaxillinQ7156477
VinculinQ424042
angiogenesisQ539568
regulation of bicellular tight junction assemblyQ15329753
Tight junction protein 1Q21096429
Cingulin like 1Q21100712
Claudin 5Q21100765
Rho/Rac guanine nucleotide exchange factor 18Q21101966
F11 receptorQ21108779
Cadherin 5Q21112896
Myosin heavy chain 2Q21119523
P21 (RAC1) activated kinase 2Q21130016
Actin betaQ21131015
Tight junction protein 1Q21496047
P304page(s)821-838
P577publication date2015-03-09
P1433published inJournal of Cell BiologyQ1524550
P1476titleZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation
P478volume208