Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus.

scientific article published on December 2009

Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E09-04-0291
P932PMC publication ID2793285
P698PubMed publication ID19828736

P50authorSabine ThelenQ84724494
Karl MatterQ43165892
Maria S. BaldaQ55117896
P2093author name stringMarouan Abouhamed
Martin Bähler
Kay Grobe
Isabelle V Leefa Chong San
Ulrike Honnert
P2860cites workDrawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 speciesQ21092862
The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23Q22010266
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticityQ24297858
Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6Q24537766
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activityQ24557505
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HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekinQ28116524
Interaction of reelin signaling and Lis1 in brain developmentQ28212561
ROCK and Dia have opposing effects on adherens junctions downstream of RhoQ28216591
Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transitionQ28248100
Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- miceQ28506558
Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetryQ28506579
Mutations in Hydin impair ciliary motility in miceQ28509898
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic nicheQ28510690
Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null miceQ28511679
The stumpy gene is required for mammalian ciliogenesisQ28512591
A novel type of myosin implicated in signalling by rho family GTPasesQ28583175
RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cellsQ28589451
The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fateQ28592768
Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cellsQ28636987
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCFQ28645084
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxPQ29615159
The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB.Q30159960
The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expressionQ30175138
Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formationQ80370540
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion.Q30480591
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membraneQ34049874
Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekinQ34589505
Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesisQ34812639
Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli geneQ34990132
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and DrosophilaQ35078438
Epithelial cell adhesion and the regulation of gene expressionQ35147365
Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies.Q35662119
Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated miceQ35810540
Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctionsQ35949016
Mammalian tight junctions in the regulation of epithelial differentiation and proliferationQ36228546
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell densityQ36322940
Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeabilityQ36324231
Cilia: tuning in to the cell's antenna.Q36557175
Epithelial tight junctions, gene expression and nucleo-junctional interplayQ36799008
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in miceQ37259094
Wnt signaling pathways meet Rho GTPases.Q37388913
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.Q39745580
The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcriptionQ39803714
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.Q40024688
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeabilityQ41151632
Microtubules containing detyrosinated tubulin are less dynamicQ42054726
Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.Q45213360
Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance studyQ46522863
Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall.Q46845544
Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice.Q46927548
Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis.Q47071993
Myr 7 is a novel myosin IX-RhoGAP expressed in rat brainQ48348573
Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturityQ48386718
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortexQ48601032
Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalusQ48697963
Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genesQ48896192
A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.Q50690435
Asynchronous transport to the cell surface of intestinal brush border hydrolases is not due to differential trimming of N-linked oligosaccharides.Q54346874
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structureQ57179984
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylationQ73847660
Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstructionQ77983643
P433issue24
P407language of work or nameEnglishQ1860
P921main subjecthydrocephalusQ193003
P304page(s)5074-5085
P577publication date2009-12-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleMyosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus
P478volume20

Reverse relations

cites work (P2860)
Q36066631A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation
Q42232216Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus
Q37936482Cellular functions of class IX myosins in epithelia and immune cells.
Q24603370Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
Q30009261Epithelial junctions and Rho family GTPases: the zonular signalosome
Q37967602Genetic approaches to study glial cells in the rodent brain.
Q30495863Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments
Q36081890Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential
Q42044690Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome
Q92303065Lessons Learned from Large-Scale, First-Tier Clinical Exome Sequencing in a Highly Consanguineous Population
Q33863489Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice.
Q41696846Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis.
Q30539772Lysophosphatidic acid signaling may initiate fetal hydrocephalus.
Q92503428Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish
Q28592732Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility
Q28117738Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression
Q36480454Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
Q35785344Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions
Q30513859Myosin-X functions in polarized epithelial cells
Q27004163Myosins in cell junctions
Q51377017Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions.
Q48401549Nuclear factor κB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation.
Q36463002Regulation of collective cell migration by RhoGAP myosin IXA
Q54261556Rho GAP myosin IXa is a regulator of kidney tubule function.
Q58561130RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
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Q37549911Self-organization of actin networks by a monomeric myosin
Q37617010Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms.
Q39604115Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
Q48113583SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle.
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Q27334469The loop2 insertion of type IX myosin acts as an electrostatic actin tether that permits processive movement
Q47154277The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis.
Q27011868The myosin superfamily at a glance.
Q36511419Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

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