Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

scientific article published on August 1998

Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.9.8.2185
P932PMC publication ID25472
P698PubMed publication ID9693375
P5875ResearchGate publication ID13592630

P50authorAnne RidleyQ21254312
P2093author name stringS Potempa
P2860cites workMolecular cloning and expression of human hepatocyte growth factorQ24305558
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transitionQ24309569
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1Q24596134
Structure and assembly of desmosome junctions: biosynthesis, processing, and transport of the major protein and glycoprotein components in cultured epithelial cellsQ27482374
Cell migration: a physically integrated molecular processQ27860682
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by RasQ28238120
Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth FactorQ58197226
Intracellular signalling. PI 3-kinase puts GTP on the RacQ71725584
Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicityQ72306296
PtdIns(3,4,5)P3 gets its message acrossQ73581091
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinaseQ28280668
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factorQ28307227
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
Scatter factor/hepatocyte growth factor is essential for liver developmentQ28504542
Small GTP-binding proteins and the regulation of the actin cytoskeletonQ28586463
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)Q28640016
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by VavQ28646540
The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell ContactsQ29042060
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cellsQ29618480
Phosphatidylinositol-3-OH kinase as a direct target of RasQ29620177
Cadherin cell adhesion receptors as a morphogenetic regulatorQ29620503
Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movementQ34294357
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.Q34442292
Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cellsQ36218386
Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cellsQ36221082
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC geneQ36232389
The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesisQ36235637
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shiftQ36236381
Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane proteinQ36237286
Multilayering and loss of apical polarity in MDCK cells transformed with viral K-rasQ36529343
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factorQ36705281
Phosphoinositide 3-kinases: a conserved family of signal transducersQ38556727
Morphogenesis of the polarized epithelial cell phenotypeQ38684855
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cellsQ40021756
Raf meets Ras: completing the framework of a signal transduction pathwayQ40682071
Breaking through the tight junction barrierQ40798811
Inhibition of invasion of epithelial cells by Tiam1-Rac signalingQ41075588
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cellsQ41075647
Ras effectorsQ41099716
Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.Q41270218
Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeletonQ41334369
Cytoskeletal and adhesion proteins as tumor suppressorsQ41334389
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinaseQ41355420
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane rufflingQ41471394
Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger.Q41554332
The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cellsQ41563732
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factorQ41656206
Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cellsQ41660869
Scatter factor affects major changes in the cytoskeletal organization of epithelial cellsQ41677051
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptorQ41879451
Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityQ42807925
An epithelial scatter factor released by embryo fibroblasts.Q43820611
The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.Q52629802
The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.Q53015839
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2185-2200
P577publication date1998-08-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleActivation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly
P478volume9