Emerging roles for XBP1, a sUPeR transcription factor

scientific article published on January 2010

Emerging roles for XBP1, a sUPeR transcription factor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3727/105221610X12819686555051
P932PMC publication ID3374844
P698PubMed publication ID21061914
P5875ResearchGate publication ID47728375

P50authorLing QiQ37375214
Shengyi SunQ37829359
P2093author name stringHui Chen
Haibo Sha
Liu Yang
Ziying Liu
Yin He
Zhen Xue
P2860cites workThe regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexesQ48106384
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.Q51981842
Activation of an unfolded protein response during differentiation of antibody-secreting B cells.Q52113898
In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesisQ52224944
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.Q53570084
American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12Q57278657
A Genome Scan in 260 Inflammatory Bowel Disease-Affected Relative PairsQ57307963
Diurnal Rhythm in Endoplasmic Reticulum of Rat Liver: Electron Microscopic StudyQ67273868
Expression of regulatory genes for lymphoplasmacytic cell differentiation in Waldenstrom MacroglobulinemiaQ83360160
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
SUMO modification regulates the transcriptional activity of XBP1Q24307512
Protective effect against Parkinson's disease-related insults through the activation of XBP1Q24314837
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT coreQ24317656
Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fosQ24318380
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagyQ24655821
PRDM16 controls a brown fat/skeletal muscle switchQ24657178
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cellsQ24658399
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
IRE1-independent gain control of the unfolded protein responseQ24798921
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.Q24815740
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegansQ27312348
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
How cells respond to interferonsQ27861006
System-wide changes to SUMO modifications in response to heat shockQ27865236
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoterQ28119099
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
SUMO: a history of modificationQ28243325
PIAS proteins: pleiotropic interactors associated with SUMOQ28248545
About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-alpha gene (ESR1) in breast cancerQ28262312
Mapping of a susceptibility locus for Crohn's disease on chromosome 16Q28275042
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
The transcription factor XBP-1 is essential for the development and survival of dendritic cellsQ28512302
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complexQ28585312
An initial blueprint for myogenic differentiationQ28588060
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
An essential role in liver development for transcription factor XBP-1Q28593777
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein responseQ28646118
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stressQ33641274
An essential role for XBP-1 in host protection against immune activation in C. elegansQ33710158
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevityQ34006688
Linkage of inflammatory bowel disease to human chromosome 6pQ34146351
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Q34882666
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasisQ35596623
Integrated molecular profiling of SOD2 expression in multiple myelomaQ35804471
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesisQ35830099
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistanceQ35856767
Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cellsQ36092602
ER stress and neurodegenerative diseasesQ36362415
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1Q36366273
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.Q36393034
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cellsQ36402768
Functionality of unspliced XBP1 is required to explain evolution of overlapping reading framesQ36620957
ER stress and diseases.Q36731474
Endoplasmic reticulum stress in disease pathogenesisQ36842308
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scaleQ36961001
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesityQ36981204
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cellsQ37181198
The endoplasmic reticulum stress response in immunity and autoimmunityQ37231726
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell developmentQ37377432
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.Q37418550
A time to fast, a time to feast: the crosstalk between metabolism and the circadian clockQ37588515
Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stageQ38322371
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorderQ38350959
Insights into the multistep transformation of MGUS to myeloma using microarray expression analysisQ38351001
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.Q38947838
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.Q40101179
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgenQ40313659
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.Q40519913
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neuronsQ40669010
Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cellsQ40947031
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.Q41844309
Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH).Q42479332
Irs1 serine 307 promotes insulin sensitivity in miceQ42563623
Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liverQ43194435
Identification of genes modulated in multiple myeloma using genetically identical twin samplesQ44582228
Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia.Q45995874
Endoplasmic reticulum stress plays a central role in development of leptin resistanceQ46178586
Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice.Q46857277
Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.Q47942024
P433issue1
P304page(s)13-25
P577publication date2010-01-01
P1433published inGene ExpressionQ15755770
P1476titleEmerging roles for XBP1, a sUPeR transcription factor
P478volume15

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