Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity

scientific article

Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.220541
P932PMC publication ID3162393
P698PubMed publication ID21757703

P50authorRichard A. MillerQ92687565
P2093author name stringAmir A Sadighi Akha
D Thomas Rutkowski
Adam B Salmon
James M Harper
Heather M Tyra
Bethany A Schroeder
P2860cites workHSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interactionQ21145793
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressQ24291026
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomeraseQ24298227
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Roles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradationQ24302539
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
Significance analysis of microarrays applied to the ionizing radiation responseQ24606608
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone productionQ28511652
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
Comparative cellular biogerontology: primer and prospectusQ28751354
Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stressQ28752254
Cell stress and aging: new emphasis on multiplex resistance mechanismsQ28755165
The mammalian unfolded protein responseQ29547400
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageingQ30497647
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
Regulation of basal cellular physiology by the homeostatic unfolded protein responseQ33886820
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevityQ34006688
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Endoplasmic reticulum stress signaling in diseaseQ36610455
Endoplasmic reticulum stress in disease pathogenesisQ36842308
Life-span extension in mice by preweaning food restriction and by methionine restriction in middle ageQ37215289
BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteinsQ39261543
Stress-induced gene expression requires programmed recovery from translational repressionQ39735685
Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf miceQ40231160
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.Q40460380
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signallingQ42045464
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathwayQ42817119
Cell biology. Apoptosis--the calcium connection.Q44391381
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.Q46317908
Multiplex stress resistance in cells from long-lived dwarf mice.Q53925947
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Is (your cellular response to) stress killing you?Q79786539
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
P4510describes a project that usesImageQuantQ112270642
P433issue35
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)30344-30351
P577publication date2011-07-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleHeightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity
P478volume286

Reverse relations

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