Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity

scientific article published on 15 October 2012

Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/CELLS1040738
P932PMC publication ID3901129
P698PubMed publication ID24710528
P5875ResearchGate publication ID261444414

P2093author name stringJoseph W Brewer
Andrew E Byrd
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responseQ24290935
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylationQ24303825
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
SUMO modification regulates the transcriptional activity of XBP1Q24307512
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein responseQ24316572
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlQ24522941
MicroRNAs: target recognition and regulatory functionsQ24609584
A CHOP-regulated microRNA controls rhodopsin expressionQ24632859
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoterQ28119099
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
Comprehensive identification of human bZIP interactions with coiled-coil arraysQ28178993
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
SUMO: a history of modificationQ28243325
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
The transcription factor XBP-1 is essential for the development and survival of dendritic cellsQ28512302
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
An essential role in liver development for transcription factor XBP-1Q28593777
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translationQ34148249
ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancerQ34168267
The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.Q34224697
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
The role of FoxO in the regulation of metabolism.Q34768157
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretionQ35008217
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasisQ35419603
FoxOs at the crossroads of cellular metabolism, differentiation, and transformationQ35770614
A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translationQ35807258
MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein responseQ35841763
Targeting XBP-1 as a novel anti-cancer strategy.Q36544398
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
XBP1: the last two decadesQ37649065
Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.Q39608147
Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregationQ39770218
pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation.Q39898784
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stressQ40286509
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.Q40519913
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.Q47942024
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P304page(s)738-753
P577publication date2012-10-15
P1433published inCellsQ27724621
P1476titleIntricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity
P478volume1

Reverse relations

cites work (P2860)
Q43431148Crosstalk between the unfolded protein response and pathways that regulate pathogenic development in Ustilago maydis.
Q92188856ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity
Q37564660Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1α and PERK pathways
Q89743106Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

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