The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production

scientific article published on 22 April 2014

The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10529-014-1537-Y
P698PubMed publication ID24752815

P50authorHirra HussainQ89198048
P2093author name stringAlan J Dickson
Rodrigo Maldonado-Agurto
P2860cites workStructure of the Ire1 autophosphorylation complex and implications for the unfolded protein responseQ24292966
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Antioxidants reduce endoplasmic reticulum stress and improve protein secretionQ36985084
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Assessment of cell engineering strategies for improved therapeutic protein production in CHO cellsQ37091960
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulumQ37186859
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Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.Q37425584
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ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER.Q37809383
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Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cellQ39162575
Metabolism and metabolic burden by α1-antitrypsin production in human AGE1.HN cellsQ39200395
A CHO cell line engineered to express XBP1 and ERO1-Lα has increased levels of transient protein expressionQ39207550
Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cellsQ39289989
A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cellsQ39381640
Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cellsQ39576071
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CHO gene expression profiling in biopharmaceutical process analysis and designQ39795757
Proteomic profiling of a high-producing Chinese hamster ovary cell cultureQ39815440
Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cellsQ39947199
Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activitiesQ39985945
Production of recombinant human factor VIII in different cell lines and the effect of human XBP1 co-expression.Q40004673
Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.Q40018099
Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cellsQ40110724
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Molecular analysis of successful cell line selection in transfected GS-NS0 myeloma cellsQ40227519
P433issue8
P921main subjectendoplasmic reticulumQ79927
P304page(s)1581-1593
P577publication date2014-04-22
P1433published inBiotechnology LettersQ4915332
P1476titleThe endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production
P478volume36

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cites work (P2860)
Q89198055A protein chimera strategy supports production of a model "difficult-to-express" recombinant target
Q37344976C1q/TNF-Related Protein 9 Protects Diabetic Rat Heart against Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress
Q51273213Cyanophycinase CphE from P. alcaligenes produced in different compartments of N. benthamiana degrades high amounts of cyanophycin in plant extracts.
Q35867141Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
Q47300551Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells.
Q40958186Expression of bioactive anti-CD20 antibody fragments and induction of ER stress response in Arabidopsis seeds
Q27008341Hijacked then lost in translation: the plight of the recombinant host cell in membrane protein structural biology projects
Q47602003In silico design of context-responsive mammalian promoters with user-defined functionality
Q37593717Label-free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines
Q37279434Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production
Q26782565The synthesis of recombinant membrane proteins in yeast for structural studies
Q38841691Transcriptional and post-transcriptional targeting for enhanced transient gene expression in CHO cells
Q38719519Use of a protein engineering strategy to overcome limitations in the production of "Difficult to Express" recombinant proteins

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