Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway

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Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...738202P
P356DOI10.1371/JOURNAL.PONE.0038202
P3181OpenCitations bibliographic resource ID3883851
P932PMC publication ID3366941
P698PubMed publication ID22675522
P5875ResearchGate publication ID225276652

P50authorEva HarrisQ5415063
P2093author name stringJosé Peña
P2860cites workER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elementsQ24310021
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory elementQ24318461
The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structureQ24336891
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
ER stress signaling by regulated proteolysis of ATF6Q81604029
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complexQ24537657
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesQ24683425
Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons.Q27469591
Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A ProteinQ27473213
West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of v 3 IntegrinQ27486120
Cholesterol Effectively Blocks Entry of FlavivirusQ27486412
Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle FormationQ27489906
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesisQ27490193
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
The lipid droplet is an important organelle for hepatitis C virus productionQ28131709
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13Q28301916
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteinsQ28640407
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segmentQ28644805
Composition and three-dimensional architecture of the dengue virus replication and assembly sitesQ29615112
Protein sensors for membrane sterolsQ29617313
The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complexQ30484619
Formation of stacked ER cisternae by low affinity protein interactionsQ31018281
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
Regulation of endoplasmic reticulum biogenesis in response to cytochrome P450 overproductionQ33639751
Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication FactoriesQ33687656
Dengue virus-induced autophagy regulates lipid metabolismQ34024721
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesisQ34182803
Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibitedQ34294116
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4BQ34416649
Not just fat: the structure and function of the lipid dropletQ34578014
Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactionsQ34632010
Hijacking the translation apparatus by RNA virusesQ34774574
Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner.Q34779622
Dengue virus modulates the unfolded protein response in a time-dependent mannerQ34800188
Translation initiation and viral tricksQ35084366
ER stress and the unfolded protein responseQ35986601
Viral RNA replication in association with cellular membranes.Q35989096
Translational control in virus-infected cells: models for cellular stress responsesQ36013956
Biogenesis of the crystalloid endoplasmic reticulum in UT-1 cells: evidence that newly formed endoplasmic reticulum emerges from the nuclear envelopeQ36215149
Wrapping things up about virus RNA replicationQ36271058
Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ36282670
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
SREBP in signal transduction: cholesterol metabolism and beyondQ36736642
Formation of crystalloid endoplasmic reticulum in COS cells upon overexpression of microsomal aldehyde dehydrogenase by cDNA transfection.Q36822559
Modification of intracellular membrane structures for virus replicationQ37139313
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulumQ37186859
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.Q37382401
Chapter 6: cubic membranes the missing dimension of cell membrane organizationQ37435117
Pathogenesis of flavivirus infections: using and abusing the host cellQ37452139
Cytoplasmic viral replication complexesQ37773687
The birth and life of lipid droplets: learning from the hepatitis C virusQ37864677
Role of endoplasmic reticulum neutral lipid hydrolasesQ37870490
Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formationQ37897618
Do viruses subvert cholesterol homeostasis to induce host cubic membranes?Q39708548
Cholesterol biosynthesis modulation regulates dengue viral replicationQ39856050
Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopyQ39977165
Cholesterol manipulation by West Nile virus perturbs the cellular immune responseQ40051201
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated mannerQ40174839
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathwayQ40650799
Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteinsQ40939802
West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasionQ41971863
Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid dropletsQ42236309
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulumQ44387449
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
Dengue virusQ476209
modulation by virus of host processQ14818042
P304page(s)e38202
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleEarly dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway
P478volume7

Reverse relations

cites work (P2860)
Q40180446A plasmid-based reporter system for live cell imaging of dengue virus infected cells
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Q28595104Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B
Q47555832Dengue virus selectively annexes endoplasmic reticulum-associated translation machinery as a strategy for co-opting host cell protein synthesis
Q47555446Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo
Q34516761Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation
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Q28222114Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
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Q64234352Genome-wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever
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Q66678721Lipophilic statins inhibit Zika virus production in Vero cells
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Q38045381Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans
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