Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation

scientific article published on June 2011

Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1042/BC20100144
P698PubMed publication ID21729000

P2093author name stringThierry Ferreira
Ivan Hapala
Esther Marza
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolQ24297732
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Dissecting the ER-associated degradation of a misfolded polytopic membrane proteinQ27930024
The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphologyQ27932399
Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particlesQ27935535
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeastQ27937464
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
ERAD: the long road to destructionQ28264823
Endoplasmic reticulum stress and atherosclerosisQ28279152
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
The life of lipid dropletsQ28749823
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
Functional genomic screen reveals genes involved in lipid-droplet formation and utilizationQ30489849
Proteomic insights into an expanded cellular role for cytoplasmic lipid dropletsQ30492685
1H NMR visible lipids in the life and death of cellsQ30604603
Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects.Q33784630
Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid dropletsQ33911325
Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cellsQ33986673
The biogenesis and functions of lipid bodies in animals, plants and microorganismsQ34084932
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cellsQ40104537
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosisQ40294776
Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.Q40295259
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitroQ40386417
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.Q40453939
The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid compositionQ40705151
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast.Q42079508
Effect of lipid particle biogenesis on the subcellular distribution of squalene in the yeast Saccharomyces cerevisiaeQ42152873
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytesQ42466809
Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeastQ42583843
Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytesQ42828051
Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant ratsQ42923731
Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletionQ43003583
Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiaeQ43285690
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.Q43687834
A yeast strain lacking lipid particles bears a defect in ergosterol formationQ44904778
Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acidsQ46080547
Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance testQ46708958
Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levelsQ46869029
Targeting of proteins involved in sterol biosynthesis to lipid particles of the yeast Saccharomyces cerevisiaeQ47444001
Phospholipid demixing and the birth of a lipid droplet.Q51718530
Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation.Q51796352
Storage lipid synthesis is non-essential in yeast.Q52544739
Obesity: stressing about unfolded proteins.Q53992488
SnapShot: The Unfolded Protein ResponseQ57032768
Quality and quantity control at the endoplasmic reticulumQ34090425
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell deathQ34564595
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranesQ34719604
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Coupling endoplasmic reticulum stress to the cell death programQ35649891
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
The unfolded protein response: a stress signaling pathway critical for health and disease.Q36375860
Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiaeQ36589761
Endoplasmic reticulum stress signaling in diseaseQ36610455
Control of fatty acid desaturation: a mechanism conserved from bacteria to humans.Q36646236
A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulationQ36869495
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic diseaseQ36910684
Initiation and execution of lipotoxic ER stress in pancreatic beta-cellsQ36910693
The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulumQ37100233
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Lipid droplet-organelle interactions; sharing the fatsQ37245509
The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cellsQ37269515
Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cellQ37269541
Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies.Q37274184
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structureQ37321469
Demonstrated and inferred metabolism associated with cytosolic lipid dropletsQ37382125
Bcl-2 family on guard at the ER.Q37412841
Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell deathQ37431426
Diabetes and apoptosis: lipotoxicityQ37473207
As a matter of fat.Q37543677
The metabolic syndrome: definition, global impact, and pathophysiologyQ37617790
Lipid-induced ER stress in yeast and β cells: parallel trails to a common fateQ37782405
Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factorsQ37838776
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulumQ38440540
Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cellsQ39616452
Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitateQ39696680
alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stressQ39797700
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytesQ39888307
P433issue6
P921main subjectendoplasmic reticulumQ79927
P1104number of pages15
P304page(s)271-285
P577publication date2011-06-01
P1433published inBiology of the CellQ1254604
P1476titleIs fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation
P478volume103

Reverse relations

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