| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Luigi Puglielli | |
| Mariana Pehar | |||
| P2860 | cites work | XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 |
| Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
| The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation | Q24293346 | ||
| Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 | Q24294341 | ||
| The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications | Q24299848 | ||
| The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 | Q24301411 | ||
| Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation | Q24307834 | ||
| Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter | Q24311902 | ||
| Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels | Q24314953 | ||
| A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy | Q24316492 | ||
| Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia | Q24533436 | ||
| A second leaky splice-site mutation in the spastin gene | Q24535936 | ||
| Relationships between carnitine and coenzyme A esters in tissues of normal and alloxan-diabetic sheep | Q42145128 | ||
| A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1. | Q42177453 | ||
| Regulation of the p300 HAT domain via a novel activation loop. | Q42458138 | ||
| Autophagy for the avoidance of neurodegeneration | Q42579165 | ||
| Production and utilization of acetate in mammals | Q42584287 | ||
| Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route | Q42660727 | ||
| Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cells | Q43120257 | ||
| PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. | Q43212730 | ||
| Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation | Q43276273 | ||
| Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis | Q44850719 | ||
| Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis. | Q44915103 | ||
| The mystery of PCSK9. | Q45009075 | ||
| Apo and inhibitor complex structures of BACE (beta-secretase). | Q45081134 | ||
| PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression | Q45383963 | ||
| Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. | Q46136271 | ||
| Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae | Q47895183 | ||
| Neurodegeneration: good riddance to bad rubbish | Q48495080 | ||
| Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. | Q53591490 | ||
| Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing. | Q54559724 | ||
| Protein acyltransferase function of purified calreticulin: the exclusive role of P-domain in mediating protein acylation utilizing acyloxycoumarins and acetyl CoA as the acyl group donors | Q64215279 | ||
| Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation | Q69628634 | ||
| Fatty Acid β-Oxidation in Peroxisomes and Mitochondria: The First, Unequivocal Evidence for the Involvement of Carnitine in Shuttling Propionyl-CoA from Peroxisomes to Mitochondria | Q72007566 | ||
| A time-dependent phase shift in the mammalian unfolded protein response | Q72997174 | ||
| RAP, a novel type of ER chaperone | Q77135315 | ||
| Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype | Q24563948 | ||
| In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker | Q24633015 | ||
| A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42) | Q24643486 | ||
| XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy | Q24655821 | ||
| Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes | Q24683425 | ||
| Autophagy: a forty-year search for a missing membrane source | Q25255981 | ||
| Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation | Q27640314 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| Lysine acetylation targets protein complexes and co-regulates major cellular functions | Q27860589 | ||
| Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p | Q27932457 | ||
| N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins | Q27932762 | ||
| GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. | Q27933920 | ||
| Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription | Q27937972 | ||
| Loss of autophagy in the central nervous system causes neurodegeneration in mice | Q28131804 | ||
| Alzheimer's disease: the cholesterol connection | Q28186482 | ||
| Regulatory mechanisms that determine the development and function of plasma cells | Q28202747 | ||
| The acetyl-CoA transporter family SLC33 | Q28203505 | ||
| A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome | Q28210032 | ||
| Oligosaccharyl transferase: gatekeeper to the secretory pathway | Q28216819 | ||
| HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention | Q28240437 | ||
| Biochemistry of mammalian peroxisomes revisited | Q28244563 | ||
| Substrate and functional diversity of lysine acetylation revealed by a proteomics survey | Q28258445 | ||
| Protein folding and quality control in the endoplasmic reticulum | Q28272791 | ||
| Human-specific nonsense mutations identified by genome sequence comparisons | Q28290107 | ||
| Structure and functions of the GNAT superfamily of acetyltransferases | Q28296840 | ||
| fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster | Q28359866 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration | Q28509904 | ||
| XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands | Q28510479 | ||
| Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9 | Q28588292 | ||
| Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia | Q28588602 | ||
| Regulation mechanisms and signaling pathways of autophagy | Q29547416 | ||
| Histone acetyltransferases | Q29547823 | ||
| PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1. | Q36862604 | ||
| Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design | Q36908436 | ||
| Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms | Q37325080 | ||
| Autophagy in neurodegeneration: two sides of the same coin | Q37532752 | ||
| Lectin-like ERAD players in ER and cytosol | Q37576338 | ||
| Mechanism and components of endoplasmic reticulum-associated degradation | Q37634749 | ||
| Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation. | Q37743010 | ||
| Regulation of intermediary metabolism by protein acetylation | Q37799059 | ||
| Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. | Q38336252 | ||
| Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9. | Q38513363 | ||
| Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation | Q39150313 | ||
| Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells | Q39589837 | ||
| Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis | Q40142846 | ||
| Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). | Q40164655 | ||
| Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. | Q40202994 | ||
| Histone acetylation: chromatin in action | Q41468916 | ||
| Autophagy and cell death: no longer at odds | Q41556141 | ||
| Autophagy is activated for cell survival after endoplasmic reticulum stress | Q29614485 | ||
| Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum | Q29614500 | ||
| Acetylation: a regulatory modification to rival phosphorylation? | Q29614886 | ||
| ATP-citrate lyase links cellular metabolism to histone acetylation | Q29615367 | ||
| GCN5-related N-acetyltransferases: a structural overview | Q29619219 | ||
| Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response | Q33264844 | ||
| Regulation of autophagy by the p300 acetyltransferase | Q33603933 | ||
| Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment | Q33767310 | ||
| ATP-citrate lyase deficiency in the mouse | Q33923761 | ||
| Tripartite management of unfolded proteins in the endoplasmic reticulum | Q33941135 | ||
| Further assembly required: construction and dynamics of the endoplasmic reticulum network | Q33962105 | ||
| AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability | Q34129501 | ||
| Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice | Q34219528 | ||
| Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals | Q34245400 | ||
| Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin | Q34246902 | ||
| SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway | Q34287569 | ||
| Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia | Q34324688 | ||
| XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation | Q34345459 | ||
| NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol | Q34347298 | ||
| Coenzyme A: back in action | Q34418810 | ||
| Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation | Q34530978 | ||
| Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling | Q34583187 | ||
| Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. | Q34624551 | ||
| Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. | Q34687421 | ||
| Hereditary spastic paraplegias: an update | Q34712075 | ||
| Quality Control and Protein Folding in the Secretory Pathway | Q35564863 | ||
| Endoplasmic reticulum stress triggers autophagy | Q35690087 | ||
| SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function | Q35838771 | ||
| Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation | Q35868173 | ||
| Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia | Q36071122 | ||
| Proteomic assessment shows that many endoplasmic reticulum (ER)-resident proteins are targeted by N(epsilon)-lysine acetylation in the lumen of the organelle and predicts broad biological impact | Q36080582 | ||
| Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase. | Q36103413 | ||
| Mechanistic insights into the regulation of metabolic enzymes by acetylation | Q36135254 | ||
| Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately | Q36383421 | ||
| ER stress and diseases. | Q36731474 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 686-697 | |
| P577 | publication date | 2012-12-13 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR. | |
| P478 | volume | 1833 |
| Q38604728 | Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon |
| Q36539478 | Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes |
| Q28078736 | Co- and Post-Translational Protein Folding in the ER |
| Q33605735 | Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer |
| Q41073215 | Developing BACE-1 inhibitors for FXS. |
| Q36722167 | Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse |
| Q30777928 | Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation |
| Q48239586 | Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy |
| Q38678550 | Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration. |
| Q93183043 | Nε-lysine acetylation in the endoplasmic reticulum - a novel cellular mechanism that regulates proteostasis and autophagy |
| Q90661931 | SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly |
| Q37297379 | SUMO and Alzheimer's disease |
| Q40776741 | Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease |
| Q64898882 | The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain. |
| Q34509754 | The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides |
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