Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish

scientific article published on 23 June 2011

Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.24396
P8608Fatcat IDrelease_w6l74siew5dpphuj2hechuuvcy
P932PMC publication ID3145024
P698PubMed publication ID21538441
P5875ResearchGate publication ID51094396

P2093author name stringChuan Gao
Ayca Cinaroglu
Dru Imrie
Kirsten C Sadler
P2860cites workER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Functional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
Network organization of the human autophagy systemQ24324004
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Intracellular signaling by the unfolded protein responseQ28250477
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathwayQ30493237
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistanceQ33556664
Site-1 protease is required for cartilage development in zebrafishQ33714544
Regulation of basal cellular physiology by the homeostatic unfolded protein responseQ33886820
Identification of 315 genes essential for early zebrafish developmentQ33979931
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feedingQ34524224
Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1Q35616432
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and GolgiQ35644888
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structureQ36468243
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed miceQ38354947
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expressionQ40343371
ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicityQ40386955
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activationQ42138693
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.Q43167089
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.Q44332232
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver diseaseQ47073806
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
Danio rerioQ169444
steatosisQ1365091
Trafficking protein particle complex subunit 11Q29821771
Membrane-bound transcription factor peptidase, site 1Q56252868
P304page(s)495-508
P577publication date2011-06-23
P1433published inHepatologyQ15724398
P1476titleActivating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish
P478volume54

Reverse relations

cites work (P2860)
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