CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response

scientific article published on 4 September 2017

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NSMB.3458
P932PMC publication ID6102046
P698PubMed publication ID28869608

P50authorBraden M. RothQ55303018
P2093author name stringBill X Wu
Bei Liu
Christopher Davies
Zihai Li
J Alan Diehl
Feng Hong
Shaoli Sun
Jordan Morreall
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chainQ24306325
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stressQ24306638
Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stressQ24322972
A thrombospondin-dependent pathway for a protective ER stress responseQ24337738
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.Q24541469
Atf4 regulates obesity, glucose homeostasis, and energy expenditureQ24648259
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expressionQ34199861
On the mechanism of sensing unfolded protein in the endoplasmic reticulumQ34230593
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperoneQ34313809
Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.Q34372272
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.Q35551757
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.Q35907138
Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy.Q36109524
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.Q37173956
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver diseaseQ37310283
Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent associationQ37687467
Modulating stress responses by the UPRosome: a matter of life and deathQ37863862
Differential scales of protein quality controlQ38200251
A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferationQ38445894
Protein misfolding in the endoplasmic reticulum as a conduit to human diseaseQ38704807
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein responseQ38845249
A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay developmentQ41120756
Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafishQ41764630
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in miceQ41825121
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafishQ47073210
Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease.Q50490679
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectCanopy FGF signaling regulator 2Q21499339
Eukaryotic translation initiation factor 2 alpha kinase 3Q21984224
P304page(s)834-839
P577publication date2017-09-04
P1433published inNature Structural & Molecular BiologyQ1071739
P1476titleCNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response
P478volume24

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cites work (P2860)
Q91554961Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity
Q92333949ERp18 regulates activation of ATF6α during unfolded protein response
Q55456504Endoplasmic Reticulum Stress in Metabolic Disorders.
Q41990861Fine-tuning PERK signaling to control cell fate under stress
Q92453248Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver
Q92510481Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury
Q104471828MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells
Q90245451Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
Q64063202Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway
Q89965531The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities
Q99564889Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress

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