Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

scientific article published on September 3, 2010

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/CIRCRESAHA.110.225698
P953full work available at URLhttps://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.225698
http://intl-circres.ahajournals.org/cgi/content/abstract/107/5/579
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.110.225698
P698PubMed publication ID20814028
P5875ResearchGate publication ID46124514

P50authorGökhan HotamışlıgilQ6033455
Sarah HummastiQ125271548
P2093author name stringGökhan S. Hotamisligil
P2860cites workReducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosisQ37465347
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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
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Inflammation and metabolic disordersQ27860923
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceQ28131660
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkkbetaQ28188643
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the GolgiQ28217040
Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistanceQ28244602
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesityQ28256254
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasQ28505821
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesQ28506402
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasisQ28510028
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver diseaseQ28571421
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytesQ40266335
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.Q40452210
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.Q40453939
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.Q40816506
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 miceQ41560139
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.Q41644055
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.Q41912120
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemiaQ42442810
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat dietQ42442818
Protein kinase C-theta mediates negative feedback on regulatory T cell functionQ42728050
Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitroQ43237166
Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese miceQ43243138
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic miceQ46082062
Endoplasmic reticulum stress plays a central role in development of leptin resistanceQ46178586
Plasma free fatty acid concentrations in obesity.Q51692828
Prevalence of High Body Mass Index in US Children and Adolescents, 2007-2008Q56621069
Remodeling Phenotype of Human Subcutaneous Adipose Tissue MacrophagesQ57321396
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
The rapidly expanding family of adipokinesQ80983945
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistanceQ81108550
Decoding cell death signals in inflammation and immunityQ83372831
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistanceQ29012156
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
IKK-beta links inflammation to obesity-induced insulin resistanceQ29614285
Macrophages, inflammation, and insulin resistanceQ29614351
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistanceQ29614354
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersQ29617381
Interleukin-1-receptor antagonist in type 2 diabetes mellitusQ29619001
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaBQ29619314
Adipocytokines: mediators linking adipose tissue, inflammation and immunityQ29619393
A central role for JNK in obesity and insulin resistanceQ29619778
Coping with stress: eIF2 kinases and translational controlQ29619787
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humansQ29622900
Obesity and the regulation of energy balanceQ30080025
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.Q30488194
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individualsQ33345339
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivityQ33367128
Nutrient sensing and inflammation in metabolic diseasesQ33623354
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.Q33896647
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.Q34024266
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Obesity and diabetes in the developing world--a growing challengeQ34603178
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasisQ34625793
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.Q34655571
Resistin- and Obesity-associated metabolic diseasesQ34704947
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistanceQ34722653
"Sick fat," metabolic disease, and atherosclerosisQ34911019
Proinsulin and the genetics of diabetes mellitusQ34977895
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodentsQ35000991
Lipotoxicity: when tissues overeatQ35168828
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
Involvement of mast cells in angiogenesis and chronic inflammationQ36048121
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
Involvement of novel PKC isoforms in FFA induced defects in insulin signalingQ36382842
Thematic review series: patient-oriented research. Nutritional determinants of insulin resistanceQ36487060
Feeding our immune system: impact on metabolismQ36494499
Attenuation of leptin and insulin signaling by SOCS proteinsQ36607776
Adipokines and the peripheral and neural control of energy balanceQ36629302
Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesityQ36846149
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetesQ36861224
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic diseaseQ36910684
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjectsQ36971939
Adipokines and insulin resistanceQ36972589
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesityQ36981204
SOCS proteins causing trouble in insulin actionQ37048806
Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammationQ37090666
T-cell fate and function: PKC-theta and beyondQ37105237
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.Q37216733
Integration of metabolism and inflammation by lipid-activated nuclear receptorsQ37225357
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Coordination of inflammation and metabolism by PPAR and LXR nuclear receptorsQ37265280
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemiaQ37325272
Adipocyte metabolism and obesityQ37328741
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in miceQ37330834
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein responseQ37389501
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.Q37400702
Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategiesQ37440055
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
endoplasmic reticulumQ79927
inflammationQ101991
stressQ123414
P304page(s)579-591
P577publication date2010-09-01
2010-09-03
P1433published inCirculation ResearchQ2599020
P1476titleEndoplasmic reticulum stress and inflammation in obesity and diabetes
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
P478volume107

Reverse relations

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Q38729665Uremia induces adipose tissue inflammation and muscle mitochondrial dysfunction
Q46467219Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans.
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