PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1.

scientific article published on October 2012

PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCB.24207
P698PubMed publication ID22644804

P2093author name stringWei Liu
Huijun Duan
Lin Zhu
Song Zhao
Jun Hao
Qingjuan Liu
Shuxia Liu
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related proteinQ24564221
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cellsQ24658399
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoterQ28119099
Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseasesQ28287571
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Proteinuria and hyperglycemia induce endoplasmic reticulum stressQ30484247
Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related proteinQ34302451
Butyrophilin controls milk fat globule secretionQ34772191
Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt.Q37165847
Endoplasmic reticulum stress in proteinuric kidney diseaseQ37610753
Endoplasmic Reticulum Stress and Inflammation in Obesity and DiabetesQ37784942
PTEN ameliorates high glucose-induced lipid deposits through regulating SREBP-1/FASN/ACC pathway in renal proximal tubular cellsQ39592426
PI3K/Akt pathway mediates high glucose-induced lipogenesis and extracellular matrix accumulation in HKC cells through regulation of SREBP-1 and TGF-β1.Q39607056
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-CellsQ39902377
In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing studyQ40022597
Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cellsQ41790209
TGF-beta1 enhances betaig-h3-mediated keratinocyte cell migration through the alpha3beta1 integrin and PI3K.Q42463588
Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathwaysQ43000096
Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in miceQ45378153
Adipocyte differentiation-related protein in human skeletal muscle: relationship to insulin sensitivityQ46675932
Cannabinoid receptor 1 mediates high glucose-induced apoptosis via endoplasmic reticulum stress in primary cultured rat mesangial cells.Q54387514
P433issue10
P304page(s)3288-3298
P577publication date2012-10-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titlePI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1.
P478volume113

Reverse relations

cites work (P2860)
Q50894540Autophagic dysfunction is improved by intermittent administration of osteocalcin in obese mice.
Q51738714Effect of Qufengtongluo Decoction on PI3K/Akt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy.
Q26799567Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
Q33790023Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca2+ and Na+ Ions and Oxidative Stress with the Participation of PKC/NOX2 and PI3K/Akt Pathways
Q89966101Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding
Q91919329Inhibition of TREM-1 attenuates inflammation and lipid accumulation in diet-induced nonalcoholic fatty liver disease
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Q104795191METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease
Q39013884PKA/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells
Q39130252Phospho-mTOR: a novel target in regulation of renal lipid metabolism abnormality of diabetes
Q46708537Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes
Q61444784Upregulated long noncoding RNA LOC105375913 induces tubulointerstitial fibrosis in focal segmental glomerulosclerosis

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