Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver.

scientific article published in February 2018

Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.REDOX.2018.01.013
P932PMC publication ID5952356
P698PubMed publication ID29482168

P2093author name stringYan Tang
Jin Qian
Meiyuan Zhang
Weilan Sun
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placentaQ24322027
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fastingQ24563197
Brain Metabolism during Fasting*Q24624240
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Q51324999
Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control studyQ74387491
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarctionQ81541774
GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational ProspectiveQ26798142
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signalingQ27008029
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The mammalian unfolded protein responseQ29547400
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolismQ34054078
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosisQ34396839
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolismQ35229188
PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid OxidationQ35568081
Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.Q35711126
Endoplasmic reticulum stress in liver diseaseQ36031838
Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced ObesityQ36434027
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolismQ36497151
Fuel metabolism in starvationQ36539491
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation.Q37052937
Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes MellitusQ37153197
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.Q37576614
Growth Differentiation Factor 15 Predicts Chronic Liver Disease SeverityQ37696054
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.Q38605925
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primatesQ38605928
Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose IntoleranceQ38672086
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.Q39616865
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.Q40056643
Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assayQ40257914
Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancersQ40568605
Elevated serum growth differentiation factor 15 levels are associated with thyroid nodules in type 2 diabetes aged over 60 yearsQ41093240
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Experimental diabetic ketoacidosis. Sequential changes of metabolic intermediates in blood, liver, cerebrospinal fluid and brain after acute insulin deprivation in the streptozotocin-diabetic ratQ42560988
Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytesQ42805165
Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese miceQ47895024
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligandQ47897710
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesityQ48043703
P921main subjectfatty acidQ61476
P304page(s)87-96
P577publication date2018-02-01
P1433published inRedox BiologyQ27724751
P1476titleFasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver.
P478volume16

Reverse relations

cites work (P2860)
Q57392984Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study
Q61449764Elevated Serum Growth Differentiation Factor 15 Levels in Hyperthyroid Patients
Q92298421Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity
Q90372105Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages
Q58601101Hepatokines-a novel group of exercise factors
Q89793794Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling
Q64064974Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases
Q90084117Nausea and vomiting of pregnancy and hyperemesis gravidarum
Q93026449Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis

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