Exendin-4 improves ER stress-induced lipid accumulation and regulates lipin-1 signaling in HepG2 cells

Exendin-4 improves ER stress-induced lipid accumulation and regulates lipin-1 signaling in HepG2 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12192-017-0872-Z
P932PMC publication ID6045528
P698PubMed publication ID29934713

P50authorEun-Jung RheeQ39502097
P2093author name stringSung-Woo Park
Cheol-Young Park
Se Eun Park
Won-Young Lee
Hyemi Kwon
Ki-Won Oh
Jinmi Lee
Seok-Woo Hong
P2860cites workExendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob miceQ24629441
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liverQ28570588
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Dual function lipin proteins and glycerolipid metabolismQ30426757
Pathogenesis of non-alcoholic fatty liver disease.Q33606303
Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolismQ34510859
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liverQ34813321
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesisQ35197073
Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in miceQ35217044
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formationQ35747483
A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolismQ35776935
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.Q35907138
Endoplasmic reticulum stress in liver diseaseQ36031838
Exendin-4 Inhibits Hepatic Lipogenesis by Increasing β-Catenin SignalingQ36209797
Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.Q36360767
ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylationQ36660203
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver diseaseQ36788344
The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver diseaseQ36954679
The lipin protein family: dual roles in lipid biosynthesis and gene expressionQ37006377
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activityQ37297861
Lipin proteins and metabolic homeostasis.Q37305229
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in miceQ37334591
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liverQ37619753
Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic ratsQ37629687
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.Q40392543
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.Q40741210
A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stressQ40890620
Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissueQ41248481
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.Q42441213
Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of ratsQ42904879
Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activityQ43143155
SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosisQ43412126
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptorQ45200756
The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient miceQ47926062
Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.Q47992984
Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophyQ59326204
[Lipin 1 in lipid metabolism]Q84627592
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)629-638
P577publication date2018-06-22
P1433published inCell Stress & ChaperonesQ13458649
P1476titleExendin-4 improves ER stress-induced lipid accumulation and regulates lipin-1 signaling in HepG2 cells
P478volume23

Reverse relations

cites work (P2860)
Q57629429Dropping in on lipid droplets: insights into cellular stress and cancer
Q92271268TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1

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