| scholarly article | Q13442814 |
| P2093 | author name string | Dong Wang | |
| Yuren Wei | |||
| Christopher L Gentile | |||
| Michael J Pagliassotti | |||
| Kyle T Pfaffenbach | |||
| Angela M Nivala | |||
| P2860 | cites work | Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta | Q22011091 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| Roles of CHOP/GADD153 in endoplasmic reticulum stress | Q24302185 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response | Q24534422 | ||
| Nonalcoholic fatty liver disease | Q24555779 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | Q28512249 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury | Q28580146 | ||
| Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls | Q29547730 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease | Q29619334 | ||
| Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. | Q30488194 | ||
| Processing of gene expression data generated by quantitative real-time RT-PCR. | Q30699578 | ||
| Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins | Q33262919 | ||
| Animal models of steatosis | Q34215195 | ||
| Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death | Q34564595 | ||
| Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking | Q35001649 | ||
| Chemical chaperones--a new concept in drug research | Q35097487 | ||
| Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response. | Q35617647 | ||
| Hepatic steatosis in obese patients: clinical aspects and prognostic significance. | Q35669794 | ||
| Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes | Q35923385 | ||
| Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents | Q36183590 | ||
| Apoptosis and fibrosis in non-alcoholic fatty liver disease. | Q36298426 | ||
| XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
| Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes | Q36861224 | ||
| Initiation and execution of lipotoxic ER stress in pancreatic beta-cells | Q36910693 | ||
| The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease | Q36954679 | ||
| Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis | Q37337488 | ||
| Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase | Q37726811 | ||
| Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53 | Q39790463 | ||
| Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation | Q40108203 | ||
| Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis | Q40108223 | ||
| Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity | Q40146370 | ||
| Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells | Q40147046 | ||
| Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells | Q40313352 | ||
| Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. | Q40368562 | ||
| Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation | Q40708272 | ||
| High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study | Q41115222 | ||
| Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase | Q42563412 | ||
| Palmitate-induced apoptosis can occur through a ceramide-independent pathway | Q43559742 | ||
| Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis | Q43802817 | ||
| Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance | Q43819530 | ||
| Rodent nutritional model of non‐alcoholic steatohepatitis: Species, strain and sex difference studies | Q44612122 | ||
| Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease | Q44934521 | ||
| Hepatospecific effects of fructose on c-jun NH2-terminal kinase: implications for hepatic insulin resistance | Q44938048 | ||
| Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells | Q46751890 | ||
| CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury | Q46823993 | ||
| JNK1 but not JNK2 promotes the development of steatohepatitis in mice | Q46865809 | ||
| Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. | Q52038310 | ||
| Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. | Q53403542 | ||
| GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells | Q63865749 | ||
| Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes | Q73579716 | ||
| Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis | Q73735584 | ||
| Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response | Q74359929 | ||
| In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease | Q79788222 | ||
| Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis | Q81441036 | ||
| Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis | Q82677113 | ||
| P433 | issue | 5 | |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| molecular chaperones | Q422496 | ||
| cell death | Q2383867 | ||
| P304 | page(s) | E1027-35 | |
| P577 | publication date | 2010-02-16 | |
| P1433 | published in | American Journal of Physiology - Endocrinology and Metabolism | Q15765671 |
| P1476 | title | Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death | |
| P478 | volume | 298 |
| Q33819901 | ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury |
| Q54327674 | Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. |
| Q28711096 | Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress |
| Q90859739 | Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease |
| Q48866711 | Antifibrotic Effect of Saturated Fatty Acids via Endoplasmic Reticulum Stress Response in Rat Pancreatic Stellate Cells |
| Q51767284 | Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency. |
| Q34648556 | Autophagy is involved in endoplasmic reticulum stress-induced cell death of rat hepatocytes |
| Q36967242 | C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis |
| Q39709114 | CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis |
| Q50043583 | CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. |
| Q38594016 | Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes |
| Q46258336 | Cell culture models of fatty acid overload: Problems and solutions |
| Q58776764 | Changes in erythrocyte polyunsaturated fatty acids and plasma eicosanoids level in patients with asthma |
| Q59806057 | Chlorogenic acid against palmitic acid in endoplasmic reticulum stress-mediated apoptosis resulting in protective effect of primary rat hepatocytes |
| Q28067773 | Copper Homeostasis for the Developmental Progression of Intraerythrocytic Malarial Parasite |
| Q37726495 | Cysteine aggravates palmitate-induced cell death in hepatocytes |
| Q33906433 | ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload |
| Q41985780 | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes |
| Q64964807 | Effects of Graded Dietary Inclusion Level of Full-Fat Hermetia illucens Prepupae Meal in Practical Diets for Rainbow Trout (Oncorhynchus mykiss). |
| Q35671675 | Elongation Factor 1A-1 Is a Mediator of Hepatocyte Lipotoxicity Partly through Its Canonical Function in Protein Synthesis |
| Q64057135 | Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis |
| Q35055531 | Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease |
| Q40282765 | Endoplasmic reticulum stress as a pro-fibrotic stimulus |
| Q36031838 | Endoplasmic reticulum stress in liver disease |
| Q38923148 | Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view |
| Q47239353 | Endoplasmic reticulum stress in the pathogenesis of fibrotic disease |
| Q36558881 | Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment |
| Q33825109 | Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells |
| Q64903572 | Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes. |
| Q37844020 | Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease |
| Q34034795 | GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy |
| Q38802501 | Gene regulation and genetics in neurochemistry, past to future. |
| Q34358474 | Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis |
| Q51760102 | HIF-1α expression as a protective strategy of HepG2 cells against fatty acid-induced toxicity. |
| Q35834009 | Heme Degradation by Heme Oxygenase Protects Mitochondria but Induces ER Stress via Formed Bilirubin |
| Q33619437 | Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis. |
| Q42202028 | Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells |
| Q39556492 | Involvement of the TLR4 (Toll-like receptor4) signaling pathway in palmitate-induced INS-1 beta cell death |
| Q39718878 | Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes |
| Q39043310 | Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells |
| Q38799232 | Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. |
| Q42812444 | Liraglutide Improves the Survival of INS-1 Cells by Promoting Macroautophagy |
| Q64229141 | Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver |
| Q35132916 | Mechanisms of lipotoxicity in NAFLD and clinical implications |
| Q35330939 | Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein |
| Q26991735 | Modulation of hepatic steatosis by dietary fatty acids |
| Q37405640 | Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease |
| Q37062751 | Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease |
| Q37815214 | New insights from rodent models of fatty liver disease |
| Q52879827 | Non-alcoholic steatohepatitis-associated hepatic fibrosis and hepatocellular carcinoma in a combined mouse model of genetic modification and dietary challenge. |
| Q90416246 | Nonalcoholic Fatty Liver Disease |
| Q37680068 | Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes |
| Q46763677 | Oxidative stress triggers cytokinesis failure in hepatocytes upon isolation |
| Q41468088 | PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death. |
| Q37625425 | Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes |
| Q38939976 | Palmitic acid-induced neuron cell cycle G2/M arrest and endoplasmic reticular stress through protein palmitoylation in SH-SY5Y human neuroblastoma cells |
| Q39417188 | Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells |
| Q36004816 | Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice |
| Q36809416 | Potential for therapeutic manipulation of the UPR in disease |
| Q38834079 | Resveratrol alleviates FFA and CCl4 induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress |
| Q35462357 | Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells |
| Q26853645 | Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease |
| Q51036933 | SIRT1/HSF1/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress. |
| Q34128069 | Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway |
| Q86542513 | Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells |
| Q57021107 | Sevoflurane relieves hepatic ischemia-reperfusion injury by inhibiting the expression of Grp78 |
| Q34557052 | Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells |
| Q36065244 | Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. |
| Q39218682 | TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway |
| Q38074493 | Targeting endoplasmic reticulum stress in metabolic disease |
| Q49990377 | Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice |
| Q61812363 | The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules |
| Q55410760 | The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes. |
| Q36592437 | The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor-induced hepatic lipotoxicity in mice |
| Q99727489 | Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? |
| Q33904744 | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes |
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